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- Löfberg, Anne-Marie, et al.
(författare)
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The use of below-knee percutaneous transluminal angioplasty in arterial occlusive disease causing chronic critical limb ischemia
- 1996
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Ingår i: Cardiovascular and Interventional Radiology. - 0174-1551 .- 1432-086X. ; 19:5, s. 317-322
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To determine the efficacy, safety and long-term results of crural artery percutaneous transluminal angioplasty (PTA) in limbs with chronic critical limb ischemia (CLI). METHODS: Patients undergoing crural artery PTA due to CLI were followed at regular clinic visits with ankle brachial pressure index (ABPI) measurements. PTA of the crural arteries was attempted either alone (n = 39) or in combination with PTA of the superficial and/or popliteal artery (n = 55) in 86 limbs (82 patients and 94 procedures) presenting with CLI. The ages of patients ranged from 37 to 94 years (mean 72 years). The indications for PTA were rest pain in 10 and ulcer/gangrene in 84 limbs. RESULTS: A technically successful PTA with at least one crural level was achieved in 88% of cases (n = 83). Cumulative primary clinical success rates at 6, 12, 24, and 36 months were 55%, 51%, 36%, and 36%, respectively. Cumulative secondary clinical success and limb salvage rates at 36 months were 44% and 72%, respectively. CONCLUSION: PTA of the crural arteries might be considered the primary choice of treatment in patients with CLI and distal lesions with localized stenosis or segmental short occlusions.
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- Ahlborg, Liv, et al.
(författare)
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Visuospatial ability correlates with performance in simulated gynecological laparoscopy
- 2011
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Ingår i: European Journal of Obstetrics, Gynecology, and Reproductive Biology. - : Elsevier BV. - 0301-2115 .- 1872-7654. ; 157:1, s. 73-77
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To analyze the relationship between visuospatial ability and simulated laparoscopy performed by consultants in obstetrics and gynecology (OBGYN). Study design: This was a prospective cohort study carried out at two community hospitals in Sweden. Thirteen consultants in obstetrics and gynecology were included. They had previously independently performed 10-100 advanced laparoscopies. Participants were tested for visuospatial ability by the Mental Rotations Test version A (MRT-A). After a familiarization session and standardized instruction, all participants subsequently conducted three consecutive virtual tubal occlusions followed by three virtual salpingectomies. Performance in the simulator was measured by Total Time, Score and Ovarian Diathermy Damage. Linear regression was used to analyze the relationship between visuospatial ability and simulated laparoscopic performance. The learning curves in the simulator were assessed in order to interpret the relationship with the visuospatial ability. Results: Visuospatial ability correlated with Total Time (r = -0.62; p = 0.03) and Score (r = 0.57; p = 0.05) in the medium level of the virtual tubal occlusion. In the technically more advanced virtual salpingectomy the visuospatial ability correlated with Total Time (r = -0.64; p = 0.02), Ovarian Diathermy Damage (r = -0.65; p = 0.02) and with overall Score (r = 0.64; p = 0.02). Conclusions: Visuospatial ability appears to be related to the performance of gynecological laparoscopic procedures in a simulator. Testing visuospatial ability might be helpful when designing individual training programs.
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- Andersson, Pehr, et al.
(författare)
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Working memory and virtual endoscopy simulation
- 2004
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Ingår i: Proceedings of the twenty-sixth annual conference of the cognitive science society. - Mahwah : Lawrence Erlbaum Associates. - 9780805854640 ; , s. 1519-1519
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Konferensbidrag (refereegranskat)
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| 6. |
- Bergqvist, David, et al.
(författare)
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Paediatric arterial trauma
- 1998
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Ingår i: European Journal of Surgery. - : Oxford University Press (OUP). - 1102-4151 .- 1741-9271. ; 164:10, s. 723-731
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Borgqvist, Martin, 1980-, et al.
(författare)
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Certifierad energikonsult livsmedelsbutiker
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna förstudie har undersökt förutsättningarna för en frivillig, ej ackrediterad certifiering av energikonsulter för livsmedelsbutiker. Det långsiktiga målet är att butiker med hjälp av certifierade energikonsulter skall få effektiva och kvalitativa energikartläggningar som innefattar såväl fastighetens som verksamhetens energianvändning och hur de olika delarna kan samverka för största möjliga energieffektivisering.Det finns en mycket stor potential att spara energi i butiker. Dagens genomsnittsbutik kan minska sin energianvändning med en tredjedel. Idag finns också en ökad miljömedvetenhet hos svenska livsmedelsbutiker, och med ett större behov av kyld mat har energifrågorna fått en allt större betydelse. Medlemmar i BELIVS Innovationskluster har länge efterfrågat en certifiering av energikonsulter för livmedelsbutiker, som utgår ifrån beställarnas behov. Detta för att öka andelen butiker med låg energianvändning, säker drift och liten miljöpåverkan.Förstudiens resultat består av; identifierade behov ur ett beställarperspektiv, en kravspecifikation som beskriver certifieringens kompetenskrav, en beskrivning av hur en certifiering är tänkt att gå till, samt ett exempel på hur ett certifieringsprov kan se ut. Dessutom har fyra stycken testcertifieringar genomförts, där exempelprovet har testats av energikonsulter. Tanken är att förstudiens resultat skall kunna användas som underlag för att ta fram ett färdigt certifieringsprogram.Den generella slutsatsen från förstudien är att certifieringen av energikonsulter för livsmedelsbutiker är genomförbar, men beställarna behöver efterfråga certifieringen i sina upphandlingar av konsulter om denna skall slå på marknaden. Baserat på diskussioner med representanter från konsultsidan, bedömer projektgruppen att det finns ett intresse för certifieringen så länge beställarna kommer att efterfråga detta. Att få fler beställare bakom den föreslagna certifieringen är den viktigaste åtgärden i ett nästa steg.RISE har drivit projektet tillsammans med INCERT, ICA Fastigheter, Coop och Hållbar Miljö & Strategi. Projektgruppen har haft kontakt med Bergendahls och Axfood vilka har deltagit vid enstaka arbetsmöten.Finansiärer av förstudien är Energimyndigheten, INCERT, ICA Fastigheter, Coop samt Bergendahls.
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| 8. |
- Bostner, Josefine, et al.
(författare)
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Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit
- 2013
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Ingår i: Breast Cancer Research and Treatment. - : Springer Verlag (Germany). - 0167-6806 .- 1573-7217. ; 137:2, s. 397-406
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Tidskriftsartikel (refereegranskat)abstract
- The frequent alterations of the PI3K/Akt/mTOR-growth signaling pathway are proposed mechanisms for resistance to endocrine therapy in breast cancer, partly through regulation of estrogen receptor alpha (ER) activity. Reliable biomarkers for treatment prediction are required for improved individualized treatment. We performed a retrospective immunohistochemical analysis of primary tumors from 912 postmenopausal patients with node-negative breast cancer, randomized to either tamoxifen or no adjuvant treatment. Phosphorylated (p) Akt-serine (s) 473, p-mTOR-s2448, and ER phosphorylations-s167 and -s305 were evaluated as potential biomarkers of prognosis and tamoxifen treatment efficacy. High expression of p-mTOR indicated a reduced response to tamoxifen, most pronounced in the ER+/progesterone receptor (PgR) + subgroup (tamoxifen vs. no tamoxifen: hazard ratio (HR), 0.86; 95 % confidence interval (CI), 0.31-2.38; P = 0.78), whereas low p-mTOR expression predicted tamoxifen benefit (HR, 0.29; 95 % CI, 0.18-0.49; P = 0.000002). In addition, nuclear p-Akt-s473 as well as p-ER at -s167 and/or -s305 showed interaction with tamoxifen efficacy with borderline statistical significance. A combination score of positive pathway markers including p-Akt, p-mTOR, and p-ER showed significant association with tamoxifen benefit (test for interaction; P = 0.029). Cross-talk between growth signaling pathways and ER-signaling has been proposed to affect tamoxifen response in hormone receptor-positive breast cancer. The results support this hypothesis, as an overactive pathway was significantly associated with reduced response to tamoxifen. A clinical pre-treatment test for cross-talk markers would be a step toward individualized adjuvant endocrine treatment with or without the addition of PI3K/Akt/mTOR pathway inhibitors.
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| 9. |
- Cunningham, Janet, et al.
(författare)
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Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms
- 2022
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 225:6, s. 965-970
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Tidskriftsartikel (refereegranskat)abstract
- Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
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| 10. |
- Cunningham, Janet L, et al.
(författare)
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Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms.
- 2022
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Ingår i: The Journal of infectious diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 225:6, s. 965-970
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Tidskriftsartikel (refereegranskat)abstract
- Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
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