| 1. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
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| 4. |
- Alinaitwe, Henry, et al.
(författare)
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Innovation Barriers and Enablers that Affect Productivity in Uganda Building Industry
- 2007
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Ingår i: Journal of Construction in Developing Countries. - Penang : Penerbit Universiti Sains Malaysia / Universiti Sains Malaysia Press. - 1823-6499 .- 2180-4222. ; 12:1, s. 59-75
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: The construction industry has of recent been blamed for lack of innovation. Lack of innovation in the industry is believed to be responsible for the decreasing or stagnant levels of productivity in comparison with other industries. This paper reviews the major barriers and enables to innovation in general. Propositions were made about the factors that affect innovation in the construction industry which were then formulated into a questionnaire. A survey was made on building contractors in Uganda, a developing country, targeting those with financial strength, large in size, and with high capacity to carry out big projects. The identified factors were then ranked and correlated. The level of training in science, engineering and technical education, and the level of research and development at the industry level are looked at as the greatest innovation enablers in building that will drive forward labour productivity. The size of the domestic market and the level of security are the worst innovation barriers that lead to low productivity in the building industry in Uganda. Contractors, policy makers and the government should address the identified factors in order to improve productivity.
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| 5. |
- AlNasseri, Hammad Abdullah, et al.
(författare)
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A taxonomy of planning and scheduling methods to support their more efficient use in construction project management
- 2016
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Ingår i: Journal of Engineering, Design and Technology. - Bingley : Emerald Group Publishing Limited. - 1726-0531 .- 1758-8901. ; 14:3, s. 580-601
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The implementation and control processes of project planning and scheduling involve a wide range of methods and tools. Despite the development and modification and integration of the project management theory with newer scheduling approaches in particular, practitioners’ views on the efficiency and effectiveness of these methods and tools differ. This situation can be attributed in part to a lack of understanding of the most appropriate basis for implementing these methods and tools. This study, therefore, aims to overcome this deficiency by conceptualizing and adopting a taxonomy of planning and scheduling methods.Design/methodology/approach: The study is based on a review and discourse analysis of the literature covering a large number of theoretical and empirical studies. The underlying theories of various planning and scheduling methods were analyzed with respect to the taxonomy criteria adopted in the study.Findings: Using the taxonomy, the key characteristics of planning and scheduling methods considered in this study were identified and interpreted. These included concepts and theories; key features; suitability and usability; and benefits and limitations. Overall, the findings suggest that project managers should consider taxonomy as a support tool for selecting and prioritizing the most appropriate method or combination of methods for managing their projects. Recommendations include the need for more advanced or multi-dimensional taxonomies to cope with the diversity of project type and size.Originality/value: The results of the study allow project managers to improve their current practices by utilizing taxonomy when considering the implementation of planning and scheduling methods. Moreover, taxonomy can be considered as a tool to promote learning on the part of those less experienced in planning and scheduling. Taxonomy can be considered as an initial platform for further research in this area. © 2016, © Emerald Group Publishing Limited.
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| 6. |
- AlNasseri, Hammad Abdullah, et al.
(författare)
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Towards a Taxonomy of Planning and Scheduling Methods in the Context of Construction Management.
- 2013
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Ingår i: [Host publication title missing]. - Trondheim : Akademika forlag. - 9788232102730 ; , s. 570-581
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Konferensbidrag (refereegranskat)abstract
- Planning and scheduling are considered as one of the most difficult but most important processes from perspectives of project management. These processes involve implementation of a widerange of planning methods used by different organizations with various levels of planning knowledge. The planning methods for scheduling can be classified as traditional methods (e.g. line of balance, Gantt chart and critical path) and modern methods (e.g. last planner and critical chain). Over time these methods had advanced from paper based to computer based. However, some project planners still prefer using the traditional methods despite other new alternatives. Users of those methods have different perspectives about the efficiency and effectiveness of the different planning methods used to manage different projects. Evidences from the secondary data found from extensive literatures have been used to assess the planning and scheduling methods mentioned above. A taxonomy describing each of the method in terms of their theories, key features, application areas, benefits and limitations is presented. The preliminary outcome of this paper may provide a tool to aid organizations in selecting and prioritizing the most appropriate methods to be developed and implemented in planning and scheduling of their projects. It also initializes a theoretical base for more rapid taxonomy studies on the use of different planning and scheduling approaches. As an overall, the present paper reminds practitioners of common ground about its important insights on how such taxonomy studies have potential to make scope of those methods and tools clearer, especially when they compare among them within the same application contexts.
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| 7. |
- Andersson, Niclas, et al.
(författare)
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Construction Innovation Systems - A Sector Approach
- 2005
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Ingår i: Understanding the Construction Business and Companies in the New Millennium. - Helsinki : VTT – Technical Research Centre of Finland & RIL – Association of Finnish Civil Engineers. - 9525004627 ; , s. 203-213
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Konferensbidrag (refereegranskat)abstract
- Recent studies depict the general need to increase and improve innovation in the construction industry. Innovation processes are traditionally described and analysed either on a macro level or a micro level. Production in construction is basically project oriented, as opposed to manufacturing industries for which most of these theories are developed. It is not fully sufficient to study innovation from a micro or a macro level due to the effects of the project orientation and the large number of actors in the construction industry. The objective of this paper is to present a model of the construction innovation systems from a sector systems approach. The study rests upon findings in the area of innovation systems in general and construction innovation systems in particular on one hand and construction sector systems analysis on the other. This paper presents arguments for the development of activity based innovation systems at a construction sector level.
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| 8. |
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| 9. |
- Anheim, F., et al.
(författare)
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Learning organizations in the Swedish construction area
- 2001
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Ingår i: [Host publication title missing]. - Göteborg : Dept. of Building Economics and Management, Dept. of Service Management, Chalmers Univ. of Technology. ; , s. 259-266, s. 259-266
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Konferensbidrag (refereegranskat)
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| 10. |
- Azouri, Kristian, et al.
(författare)
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Hotellrapport Stockholm
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- Stockholm är Sveriges största stad och marknadsför sig som ”The Capital of Scandinavia”. De flesta resenärer som besöker Sverige åker till just Stockholm. År 2010 nådde Stockholms län 10 miljoner kommersiella övernattningar. Det är lätt att ta sig till Stockholm med både flyg, tåg, båt, bil och buss. Stockholm har ett brett utbud av kongress- och mässanläggningar. År 2009 var Stockholm den sjunde mest populära staden i världen att förlägga kongresser på. I dagsläget är Sverige på väg ur den lågkonjunktur som startade år 2008. Sveriges BNP och valuta är på väg att stabiliseras och stärkas. Regeringen har även lagt in ett förslag om att sänka tjänstemomsen inom hotell- och restaurangbranschen. I denna rapport har vi valt att avgränsa oss till ett eget utvalt område inom Stockholm. Detta område innefattar 143 hotell med 20 054 hotellrum.De prognoser vi gjort gällande staden Stockholm och segmenten affärsresenärer och fritidsresenärer pekar på en ökning av besökare till staden. Detta kommer resultera i att hotellens beläggning, snittpris och RevPAR kommer att öka framtill år 2013. Efter år 2013 tror vi att segmentet affärsresenärer kommer att minska något procentuellt och kurvan för belagda nätter kommer att stabiliseras. Dock tror vi att segmentet fritidsresenärer kommer att öka procentuellt efter år 2013 och antalet belagda hotellrum kommer att successivt öka mellan åren 2011 – 2015. Vi tror att snittpris och RevPAR kommer att sjunka på grund av att en fritidsresenär generellt sätt inte betalar lika mycket för ett hotellrum som en affärsresenär gör.
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