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Numrering	Referens	Omslagsbild	Hitta
1.	Aung, T, et al. (författare) Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci 2017 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:7, s. 993- Tidskriftsartikel (refereegranskat)
2.	Blackwell, TA, et al. (författare) Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice 2018 Ingår i: Physiological genomics. - : American Physiological Society. - 1531-2267 .- 1094-8341. ; 50:12, s. 1071-1082 Tidskriftsartikel (refereegranskat)abstract Cancer-cachexia (CC) is a wasting condition directly responsible for 20–40% of cancer-related deaths. The mechanisms controlling development of CC-induced muscle wasting are not fully elucidated. Most investigations focus on the postcachectic state and do not examine progression of the condition. We recently demonstrated mitochondrial degenerations precede muscle wasting in time course progression of CC. However, the extent of muscle perturbations before wasting in CC is unknown. Therefore, we performed global gene expression analysis in CC-induced muscle wasting to enhance understanding of intramuscular perturbations across the development of CC. Lewis lung carcinoma (LLC) was injected into the hind-flank of C57BL6/J mice at 8 wk of age with tumor allowed to develop for 1, 2, 3, or 4 wk and compared with PBS-injected control. Muscle wasting was evident at 4 wk LLC. RNA sequencing of gastrocnemius muscle samples showed widespread alterations in LLC compared with PBS animals with largest differences seen in 4 wk LLC, suggesting extensive transcriptomic alterations concurrent to muscle wasting. Commonly altered pathways included: mitochondrial dysfunction and protein ubiquitination, along with other less studied processes in this condition regulating transcription/translation and cytoskeletal structure. Current findings present novel evidence of transcriptomic shifts and altered cellular pathways in CC-induced muscle wasting.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Kazama, S. (1); Kubota, T. (1); Xu, L. (1); Zhang, H. (1); Sugimoto, T. (1); Nelson, S. (1); visa fler...; Ghosh, A (1); Li, Z (1); Jonas, JB (1); Topouzis, F (1); Raychaudhuri, S (1); Hayashi, K. (1); Ozaki, M. (1); Hauser, M. (1); Roy, S (1); Wang, JJ (1); Mori, K. (1); Yoshida, A. (1); Kang, JH (1); Cheng, CY (1); Nothen, MM (1); Wong, TY (1); Ikeda, Y (1); Sim, KS (1); Ruas, JL (1); Rao, A. (1); Khatri, B (1); Ahn, J. (1); Cervenka, I (1); Inoue, K (1); George, R (1); Thomas, S (1); Kraft, P (1); Heegaard, S (1); Chen, XY (1); Chen, YM (1); Saravanan, V. (1); Thorleifsson, G (1); Moebus, S (1); Thorsteinsdottir, U (1); Stefansson, K (1); Herms, S. (1); Khor, CC (1); Hibberd, ML (1); Reis, A (1); Lambropoulos, A (1); Ueno, M. (1); Ramsay, M (1); Aung, T (1); Lee, MC (1); visa färre...

Lärosäte: Karolinska Institutet (2)

Språk: Engelska (2)

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