| 1. |
- Lehmann, Philipp, et al.
(författare)
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Metabolome dynamics of diapause in the butterfly Pieris napi: Distinguishing maintenance, termination and post-diapause phases
- 2018
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Ingår i: Journal of Experimental Biology. - : The Company of Biologists. - 1477-9145 .- 0022-0949. ; 221:2
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Tidskriftsartikel (refereegranskat)abstract
- Diapause is a deep resting stage facilitating temporal avoidance of unfavourable environmental conditions, and is used by many insects to adapt their life cycle to seasonal variation. Although considerable work has been invested in trying to understand each of the major diapause stages (induction, maintenance and termination), we know very little about the transitions between stages, especially diapause termination. Understanding diapause termination is crucial for modelling and predicting spring emergence and winter physiology of insects, including many pest insects. In order to gain these insights, we investigated metabolome dynamics across diapause development in pupae of the butterfly Pieris napi, which exhibits adaptive latitudinal variation in the length of endogenous diapause that is uniquely well characterized. By employing a time-series experiment, we show that the whole-body metabolome is highly dynamic throughout diapause and differs between pupae kept at a diapause-terminating (low) temperature and those kept at a diapause-maintaining (high) temperature. We show major physiological transitions through diapause, separate temperature-dependent from temperature-independent processes and identify significant patterns of metabolite accumulation and degradation. Together, the data show that although the general diapause phenotype (suppressed metabolism, increased cold tolerance) is established in a temperature-independent fashion, diapause termination is temperature dependent and requires a cold signal. This revealed several metabolites that are only accumulated under diapause-terminating conditions and degraded in a temperatureunrelated fashion during diapause termination. In conclusion, our findings indicate that some metabolites, in addition to functioning as cryoprotectants, for example, are candidates for having regulatory roles as metabolic clocks or time-keepers during diapause.
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| 2. |
- Wiklund, Lars, 1954, et al.
(författare)
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Neurogenetik.
- 2006
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Ingår i: Neurologi. Fagius J och Aquilonius S-M (ed.). - Stockholm : Liber. - 9789147053131
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Antonsson, Ann-Beth, et al.
(författare)
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Litteraturöversikt över aldehyders biologiska effekter, förekomst i arbetsmiljön och mätmetoder.
- 1985
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Formaldehyds allergiframkallande och ev cancerframkallande egenskaper har fäst uppmärksamheten på gruppen aldehyder, i vilken formaldehyd ingår. Gruppen aldehyder har det gemensamt att de flesta är irriterande för ögon och slemhinnor. Några av aldehyderna är dessutom allergiframkallande. För de flesta aldehyder finns inte tillräckliga kunskaper för att avgöra om de kan framkalla cancer eller fosterskador. Aldehyder används i de flesta branscher och ofta på ett sådant sätt att människor kommer i kontakt med aldehyder. Rapporten beskriver på ett lättbegripligt sätt - olika aldehyder och deras användningsområde, - biologiska effekter av aldehyder, - halter av aldehyder i arbetsmiljön, - gränsvärden, regler och normer. I rapportens sista kapitel anges vad man kan göra för att minska kontakten med aldehyder i arbetsmiljön.
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| 4. |
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| 5. |
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| 6. |
- Eriksson, Kåre, et al.
(författare)
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Dermal exposure to monoterpenes during wood work.
- 2004
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Ingår i: Journal of Environmental Monitoring. - : Royal Society of Chemistry (RSC). - 1464-0325 .- 1464-0333. ; 6:6, s. 563-8
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Tidskriftsartikel (refereegranskat)abstract
- The dermal exposure to the suspected allergenic monoterpenes [small alpha]-pinene, [small beta]-pinene and [capital Delta](3)-carene was assessed with a patch sampling technique. The patch used was made of activated charcoal sandwiched between two layers of cotton cloth. Patches were fastened at 12 different spots on a sampling overall and at the front of a cap to estimate the potential exposure of the body. Fastening two patches on a cotton glove, one patch representing the dorsal side and one patch representing the palm of the hand respectively, assessed the exposure on the hands. Sampling was carried out during collecting of pine and spruce boards in sawmills and during sawing of pine wood pieces in joinery shops respectively. The potential dermal exposure of the total body was 29.0-1 890 mg h(-1) with a geometric mean (GM) of 238 mg h(-1) during sawing. During collecting the GM was estimated to 100 mg h(-1) with a range of 12.2-959 mg h(-1). The hands had a mean exposure of 9.24 mg h(-1) during sawing and 3.25 mg h(-1) during collecting respectively. The good correlation between the mass of contamination on the individual body parts and the potential body exposure indicates that sampling can be performed on one body part to give a good estimation of the potential body exposure. Monoterpenes were detected at patches fastened underneath the protective clothing indicating a contamination of the skin of the worker. The patch used may overestimate the dermal exposure.
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| 7. |
- Eriksson, Kåre, et al.
(författare)
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Dermal exposure to styrene in the fibreglass reinforced plastics industry.
- 2004
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press (OUP). - 0003-4878 .- 1475-3162. ; 48:3, s. 203-8
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim of this study was to assess the potential dermal exposure to styrene in the fibreglass reinforced plastics industry. METHODS: Assessment was performed during spraying and rolling using a patch sampling technique. The patch was made of charcoal sandwiched between two layers of cotton fabric. Samplers were fastened at 12 different spots on a sampling overall, each spot representing a body area. One patch was fastened at the front of a cap. A patch fastened to a string worn around the neck assessed the exposure at chest level inside the clothing. Patches were fastened to cotton gloves at sites representing the dorsal side and the palm of the hand to evaluate exposure on these areas. Following sampling the patches were solvent desorbed and styrene was analysed by gas chromatography flame ionization detection. RESULTS: The potential body exposure for the participating individuals was between 544 and 17 100 mg/h with a geometric mean (GM) of 3780 mg/h. The legs, arms and outer chest in general had the highest exposures. The left and right hands had mean (GM) exposures of 344 and 433 mg/h, respectively. Styrene was determined for the patch at the inside of the clothing, indicating contamination of the dermal layer. CONCLUSIONS: The charcoal patch can be used to evaluate potential exposure to styrene. The results indicate that the dermal layer of the worker is exposed to styrene. Precautions should be performed to reduce dermal exposure.
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| 8. |
- Eriksson, Kåre, et al.
(författare)
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Dermal exposure to terpenic resin acids in Swedish carpentry workshops and sawmills
- 2004
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press. - 0003-4878 .- 1475-3162. ; 48:3, s. 267-275
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aim of this study was to evaluate dermal exposure to the resin acids abietic acid, dehydroabietic acid and 7-oxodehydroabietic acid during collecting in sawmills and during sawing in carpentry workshops, respectively. METHODS: Sampling was performed by fastening patches at 12 different areas on a sampling overall, one patch on the front of a cap, one patch on the chest inside the clothing and one patch on the inner lower right leg. Exposure of the hands was assessed by fastening patches on cotton gloves representing the dorsal sides and the palms of the left and right hands. Sampling was performed on 30 different occasions in the sawmills and in the carpentry workshops with mean sampling times of 120 and 59 min, respectively. The acids were solvent desorbed from the patches. Identification and quantification of the resin acids was performed by gas chromatography-mass spectrometry. RESULTS: The geometric means (GMs) of the potential body exposures to abietic acid, dehydroabietic acid and 7-oxodehydroabietic acid during sawing and collecting of wood from pine and spruce were 3346 and 17 247 micro g/h, respectively. The GM of the potential exposure on the hands was 3020 micro g/h in the carpentry workshops and 4365 micro g/h in the sawmills. Resin acids were detected on the inner chest and inner lower front right leg, respectively. CONCLUSIONS: There is a potential dermal exposure to terpenic resin acids in carpentry workshops as well as in sawmills. The hands have the highest exposure during sawing as well as during collecting. There is a spatial distribution of contaminants, with the outer chest, arms and legs showing the highest exposures. Resin acids also contaminated the inner chest and inner lower leg. It is necessary to take action to reduce dermal exposure to these allergenic substances.
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| 9. |
- Forsgren, Lars, et al.
(författare)
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Neurogenetik
- 2004
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Ingår i: Incitament. ; , s. 25-28
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Forskningsöversikt (populärvet., debatt m.m.)
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| 10. |
- Guo, Li, et al.
(författare)
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Disappearing sensor : Textile based sensor for monitoring breathing
- 2011
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The monitoring and interpretation of respiration pattern plays an important role for the early detection and the prevention of serious illness, such as asthma, sleeping apnea, bronchitis, and lung cancer. In this interdisciplinary project a system based on a smart shirt with integrated textile sensor for personal respiratory monitoring was developed. Due to the fact that textile products are flexible, washable and bring no discomfort to wearers, the smart shirtis an excellent interface for performing long term respiratory monitoring in real life situations outside the clinic. Two stripe liked sensors located on the chest and abdomen position respectively were integrated in a smart shirt. The sensors were made by coating with conductive silicone on the fabric surface of the smart shirt. Conductive silicone reflects compression or extension by resistance change and in this application resistance change can be utilized to indicate the respiratory pattern of the wearer. A prototype system was made to record the resistance change in real time and transmission to a PC or PDA for further processing. Snap button and conductive threads were used as the interface and transmission wires between the smart shirt and the recording system. To verify the performance, test were made with 10 subjects, whose spontaneous respiratory patterns were recorded during sitting still, walking and jogging. In addition, a number of abnormal respiratory conditions, such as deep breathing, hyperventilation and sleeping apnea were simulated. The results show the smart shirt performed in a very good manner, the system can sense and record the person's breathing during normal daily activities. The sleeping apnea simulation indicates potential application in diagnosis and clinical treatment. The smart shirt is soft and comfortable to use and enables long-term monitoring to be performed outside the laboratory.
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