| 1. |
- Gustafsson, Mats, et al.
(författare)
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Effekter av vinterdäck : en kunskapsöversikt
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Choice of winter tyres has, from mainly being a matter of safety and economic costs for wearing of road pavements, during later years also become a matter of inhalable particles formed during pavement wear from studded tyres and their negative effects on public health. Further, the tyres' effects on environment and noise have been illustrated in several studies. The issue is also complicated by the fact that tyre choice effects on traffic safety have several components, including such diverging parameters as friction and behaviour. Finally all aspects have to be evaluated from a socioeconomic point of view for society to be able to decide which kind of distribution of tyre types that is the most profitable. This report is a summary of current knowledge in this complex research field.
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| 2. |
- Mansouri, Larry, et al.
(författare)
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Functional loss of I kappa B epsilon leads to NF-kappa B deregulation in aggressive chronic lymphocytic leukemia
- 2015
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 212:6, s. 833-843
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Tidskriftsartikel (refereegranskat)abstract
- NF-kappa B is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-kappa B pathway in a discovery and validation CLL cohort totaling 315 cases. The most frequently mutated gene was NFKBIE (21/315 cases; 7%), which encodes I kappa B epsilon, a negative regulator of NF-kappa B in normal B cells. Strikingly, 13 of these cases carried an identical 4-bp frameshift deletion, resulting in a truncated protein. Screening of an additional 377 CLL cases revealed that NFKBIE aberrations predominated in poor-prognostic patients and were associated with inferior outcome. Minor subclones and/or clonal evolution were also observed, thus potentially linking this recurrent event to disease progression. Compared with wild-type patients, NFKBIE-deleted cases showed reduced I kappa B epsilon protein levels and decreased p65 inhibition, along with increased phosphorylation and nuclear translocation of p65. Considering the central role of B cell receptor (BcR) signaling in CLL pathobiology, it is notable that I kappa B epsilon loss was enriched in aggressive cases with distinctive stereotyped BcR, likely contributing to their poor prognosis, and leading to an altered response to BcR inhibitors. Because NFKBIE deletions were observed in several other B cell lymphomas, our findings suggest a novel common mechanism of NF-kappa B deregulation during lymphomagenesis.
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| 3. |
- Mansouri, Larry, et al.
(författare)
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Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia.
- 2015
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 212:6, s. 833-843
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Tidskriftsartikel (refereegranskat)abstract
- NF-κB is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-κB pathway in a discovery and validation CLL cohort totaling 315 cases. The most frequently mutated gene was NFKBIE (21/315 cases; 7%), which encodes IκBε, a negative regulator of NF-κB in normal B cells. Strikingly, 13 of these cases carried an identical 4-bp frameshift deletion, resulting in a truncated protein. Screening of an additional 377 CLL cases revealed that NFKBIE aberrations predominated in poor-prognostic patients and were associated with inferior outcome. Minor subclones and/or clonal evolution were also observed, thus potentially linking this recurrent event to disease progression. Compared with wild-type patients, NFKBIE-deleted cases showed reduced IκBε protein levels and decreased p65 inhibition, along with increased phosphorylation and nuclear translocation of p65. Considering the central role of B cell receptor (BcR) signaling in CLL pathobiology, it is notable that IκBε loss was enriched in aggressive cases with distinctive stereotyped BcR, likely contributing to their poor prognosis, and leading to an altered response to BcR inhibitors. Because NFKBIE deletions were observed in several other B cell lymphomas, our findings suggest a novel common mechanism of NF-κB deregulation during lymphomagenesis.
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| 4. |
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| 5. |
- Agrell, Beata, et al.
(författare)
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Ett laglöst tillstånd
- 2012
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Annan publikation (populärvet., debatt m.m.)
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| 6. |
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| 7. |
- Andersson, Mats, et al.
(författare)
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Filter Networks
- 1999
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Ingår i: Proceedings of Signal and Image Processing (SIP'99). - Nassau, Bahamas : IASTED. - 0889862672 ; , s. 213-217
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Konferensbidrag (refereegranskat)abstract
- This paper presents a new and efficient approach for optimization and implementation of filter banks e.g. velocity channels, orientation channels and scale spaces. The multi layered structure of a filter network enable a powerful decomposition of complex filters into simple filter components and the intermediary results may contribute to several output nodes. Compared to a direct implementation a filter network uses only a fraction of the coefficients to provide the same result. The optimization procedure is recursive and all filters on each level are optimized simultaneously. The individual filters of the network, in general, contain very few non-zero coefficients, but there are are no restrictions on the spatial position of the coefficients, they may e.g. be concentrated on a line or be sparsely scattered. An efficient implementation of a quadrature filter hierarchy for generic purposes using sparse filter components is presented.
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| 8. |
- Andersson, Mats, et al.
(författare)
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Sequential Filter Trees for Efficient 2D 3D and 4D Orientation Estimation
- 1998
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A recursive method to condense general multidimensional FIR-filters into a sequence of simple kernels with mainly one dimensional extent has been worked out. Convolver networks adopted for 2, 3 and 4D signals is presented and the performance is illustrated for spherically separable quadrature filters. The resulting filter responses are mapped to a non biased tensor representation where the local tensor constitutes a robust estimate of both the shape and the orientation (velocity) of the neighbourhood. A qualitative evaluation of this General Sequential Filter concept results in no detectable loss in accuracy when compared to conventional FIR (Finite Impulse Response) filters but the computational complexity is reduced several orders in magnitude. For the examples presented in this paper the attained speed-up is 5, 25 and 300 times for 2D, 3D and 4D data respectively The magnitude of the attained speed-up implies that complex spatio-temporal analysis can be performed using standard hardware, such as a powerful workstation, in close to real time. Due to the soft implementation of the convolver and the tree structure of the sequential filtering approach the processing is simple to reconfigure for the outer as well as the inner (vector length) dimensionality of the signal. The implementation was made in AVS (Application Visualization System) using modules written in C.
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| 9. |
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| 10. |
- Antonson, Hans, et al.
(författare)
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Crash Barriers and Driver Behavior : A Simulator Study
- 2013
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Ingår i: Traffic Injury Prevention. - : Informa UK Limited. - 1538-9588 .- 1538-957X. ; 14:8, s. 874-880
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The study examines how drivers experience a conventional W-beam guardrail (metal crash barrier) along both sides of narrow versus wider roads (single carriageway with 2 lanes) in terms of stress, feelings, and driving patterns and whether subjective experience concurs with the actual driving patterns captured by the quantitative data.Methods: The study used different methods to capture data, including the VTI Driving Simulator III (speed and lateral vehicle position) in conjunction with electrocardiogram (ECG) data on heart rate variability (HRV) and questionnaires (oral during driving and written after driving). Eighteen participants-8 men and 10 women-were recruited for the simulator study and the simulator road section was 10 km long.Results: Driving speeds increased slightly on the wider road and on the road with a crash barrier, and the lateral driving position was nearer to the road center on the narrower road and on the road with a crash barrier. The HRV data did not indicate that participants experienced greater stress due to road width or due to the presence of a crash barrier. Participant experience captured in the oral questionnaires suggested that road width did not affect driver stress or driving patterns; however, the written questionnaire results supported the simulator data, indicating that a wider road led to increased speed. None of the participants felt that crash barriers made them feel calmer.Conclusions: We believe that there is a possibility that the increased speed on roads with crash barriers may be explained by drivers’ sense of increased security. This study demonstrates that an experimental design including experience-based data captured using both a simulator and questionnaires is productive. It also demonstrates that driving simulators can be used to study road features such as crash barriers. It seems more than likely that features such as street lamps, signs, and landscape objects could be tested in this way. © 2013 Copyright Taylor and Francis Group, LLC.
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