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- Asplund, Sara, 1976, et al.
(författare)
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Extended analysis of the effect of learning with feedback on the detectability of pulmonary nodules in chest tomosynthesis
- 2011
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Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE. - 1605-7422. ; 7966
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In chest tomosynthesis, low-dose projections collected over a limited angular range are used for reconstruction of section images of the chest, resulting in a reduction of disturbing anatomy at a moderate increase in radiation dose compared to chest radiography. In a previous study, we investigated the effects of learning with feedback on the detection of pulmonary nodules in chest tomosynthesis. Six observers with varying degrees of experience of chest tomosynthesis analyzed tomosynthesis cases for presence of pulmonary nodules. The cases were analyzed before and after learning with feedback. Multidetector computed tomography (MDCT) was used as reference. The differences in performance between the two readings were calculated using the jackknife alternative free-response receiver operating characteristics (JAFROC-2) as primary measure of detectability. Significant differences between the readings were found only for observers inexperienced in chest tomosynthesis. The purpose of the present study was to extend the statistical analysis of the results of the previous study, including JAFROC-1 analysis and FROC curves in the analysis. The results are consistent with the results of the previous study and, furthermore, JAFROC-1 gave lower p-values than JAFROC-2 for the observers who improved their performance after learning with feedback. © 2011 SPIE.
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| 4. |
- Sofou, Kalliopi, et al.
(författare)
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Prenatal onset of mitochondrial disease is associated with sideroflexin 4 deficiency
- 2019
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Ingår i: Mitochondrion. - : Elsevier BV. - 1567-7249. ; 47, s. 76-81
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Tidskriftsartikel (refereegranskat)abstract
- Prenatal onset of mitochondrial disease has been described in two cases with recessive mutations in the sideroflexin 4 gene (SFXN4). We present a third case with complex I deficiency associated with novel mutations in SFXN4. Our patient presented with intrauterine growth retardation, neonatal lactic acidosis, and developed macrocytic anemia and optic nerve hypoplasia. Muscle mitochondrial investigations revealed ultrastructural abnormalities, severe deficiency of complex I enzyme activity, and loss of subunit proteins. Whole-exome sequencing revealed bi-allelic SFXN4 mutations: a 1-base deletion, c.969delG, leading to frameshift and a premature stop codon, p.(G1n323Hisfs*20), and a stop-loss mutation in the C-terminal region, c.1012 T > C; p. (*388Glnext2), resulting in elongation of the protein by two amino acids. Expression analysis of mRNA from muscle showed loss of SFXN4 transcripts.
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| 5. |
- Wiksell, Kristin, 1989-
(författare)
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Organizing for Social Change : Worker Cooperatives as Resistance to Capitalism
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- When people around the globe are increasingly confronted with the challenges of rising economic inequalities and declining democratization, often associated with the spread of globalized capitalism, it becomes difficult to defend a position of business as usual. Worker co-ops are economic associations equally owned and democratically governed by workers with the potential to contribute to economic democracy and social change. This dissertation explores how worker cooperatives, primarily in Sweden, are constructed and organized by co-operators in ways that can resist capitalism, while at the same time having to relate to capitalism as the context in which they operate. The analyzed empirical material includes an international marketing campaign promoting co-ops; qualitative material, mainly interviews, from five Swedish worker co-ops; and second-hand material on timebanks, network-based exchange services. Overall, the results show that co-operators construct worker co-ops as better for individuals and societies than capitalist-oriented organizing, which is associated with economic ideals for profit and growth and hierarchical control. In contrast, the worker co-ops organize themselves as a form of constructive resistance to capitalism by enacting social ideals such as freedom to self-govern, equal work relations through friendship and the valuing of work time, perceived to benefit society without generating profit. The co-ops’ very existence demonstrates and spreads awareness that this alternative form of organizing is viable in the here and now. However, the analysis also shows that co-ops’ resistance within capitalist market economic contexts involves risks of the reproduction of power and the compromise of ideals in order to survive. Thereby, this dissertation contributes to knowledge on the possibilities and pitfalls of organizing for social change within contexts dominated by the very power resistance is directed against.
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