| 1. |
- Andersson, Erik, et al.
(författare)
-
Cost-effectiveness of internet-based cognitive behavior therapy for obsessive-compulsive disorder : results from a randomized controlled trial
- 2015
-
Ingår i: Journal of Obsessive-Compulsive and Related Disorders. - : Elsevier. - 2211-3649 .- 2211-3657. ; 4, s. 47-53
-
Tidskriftsartikel (refereegranskat)abstract
- Obsessive-compulsive disorder (OCD) is a common and disabling disorder. Although evidence-based psychological treatments exists, such as cognitive behavior therapy (CBT), the cost-effectiveness of CBT has not been properly investigated. In this trial, we used health economic data from a recently conducted randomized controlled trial, where 101 OCD patients were allocated to either internet-based CBT (ICBT) or control condition (online support therapy). We analyzed treatment effectiveness in relation to costs, using both a societal- (including all direct and indirect costs) and a health care unit perspective (including only the direct treatment costs). Bootstrapped net benefit regression analyses were also conducted, comparing the difference in costs and effects between ICBT and control condition, with different willingness-to-pay scenarios. Results showed that ICBT produced one additional remission for an average societal cost of $931 and this figure was even lower ($672) when narrowing the perspective to treatment costs only. The cost-utility analysis also showed that ICBT generated one additional QALY to an average price of $7186 from a societal perspective and $4800 when just analyzing the treatment costs. We conclude that ICBT is a cost-effective treatment and the next step in this line of research is to compare the cost-effectiveness of ICBT with face-to-face CBT. (C) 2014 Elsevier Inc. All rights reserved.
|
|
| 2. |
- Lind, Jacob, et al.
(författare)
-
Jakt på papperslösa gör oss till en polisstat
- 2016
-
Ingår i: Svenska Dagbladet. - : Svenska Dagbladet. - 1101-2412. ; :2016-10-04
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Regeringen föreslår nio åtgärder för att hitta och utvisa papperslösa. Det kommer att slå hårt och främst gå ut över redan svaga och jagade människor. Vi uppmanar därför regeringen att ta tillbaka åtgärderna, skriver 43 forskare.
|
|
| 3. |
- Wikström, Anders, et al.
(författare)
-
Storyboarding - Framing the "frame" of opportunity
- 2013
-
Konferensbidrag (refereegranskat)abstract
- The design brief is commonly a written description of a scope for a design problem that requires some kind of visual design. The exploration of opportunities before formulating the design brief results in framing and reframing the problem to create a common shared understanding of the problem. In this paper the applicability of Storyboard, the actual making of the storyboard, and its values to the front-front end of innovation is examined. Experiments has been performed in order to test three hypotheses and validate the results, in total four experiments was performed consisting of 25 teams developing 17 concepts. The three hypotheses focus, regarding type of innovation, scope and level of ambiguity, creates understanding of the values storyboarding can add with regards to framing opportunity for innovation in the front-front end of innovation. The result shows that storyboarding contribute to a narrow focus in creating the brief. Regarding the innovation type the hypothesis could not be confirmed, but storyboarding enables a reflection on both meaning and function. There were also some indications on ambiguity in the brief, but this hypothesis was not confirmed.© 2013 The Design Society.
|
|
| 4. |
- Åberg, Anna-Maja, et al.
(författare)
-
High monocyte count and expression of s100a9 and s100a12 in peripheral blood mononuclear cells are associated with poor outcome in patients with metastatic prostate cancer
- 2021
-
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:10
-
Tidskriftsartikel (refereegranskat)abstract
- Increasing evidence indicates calcium-binding S100 protein involvement in inflammation and tumor progression. In this prospective study, we evaluated the mRNA levels of two members of this family, S100A9 and S100A12, in peripheral blood mononuclear cells (PBMCs) in a cohort of 121 prostate cancer patients using RT-PCR. Furthermore, monocyte count was determined by flow cytometry. By stratifying patients into different risk groups, according to TNM stage, Gleason score and PSA concentration at diagnosis, expression of S100A9 and S100A12 was found to be significantly higher in patients with metastases compared to patients without clinically detectable metastases. In line with this, we observed that the protein levels of S100A9 and S100A12 in plasma were higher in patients with advanced disease. Importantly, in patients with metastases at diagnosis, high monocyte count and high levels of S100A9 and S100A12 were significantly associated with short progression free survival (PFS) after androgen deprivation therapy (ADT). High monocyte count and S100A9 levels were also associated with short cancer-specific survival, with monocyte count providing independent prognostic information. These findings indicate that circulating levels of monocytes, as well as S100A9 and S100A12, could be biomarkers for metastatic prostate cancer associated with particularly poor prognosis.
|
|
