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| 2. |
- Balducci, Alessandro, et al.
(författare)
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Introduction: Strategic spatial planning in uncertainty : theory and exploratory practice
- 2011
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Ingår i: Town planning review. - : Liverpool University Press. - 0041-0020 .- 1478-341X. ; 82:5, s. 481-501
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Tidskriftsartikel (refereegranskat)abstract
- The papers in this issue develop practical and theoretical ideas about strategic spatial planning in uncertainty. This Introduction contextualises the papers in terms of spatial planning and the uncertainties that planning practitioners face as they attempt to cope with the messiness of strategy-making and implementation. The authors explain their understanding of post-structuralism and how it differs from the pragmatist theoretical foundations of other scholars. The five papers are introduced through the use of recurring themes. The Introduction concludes by proposing that post-structuralist ideas can work to improve planning practice in conditions of uncertainty, provided that key elements are in place.
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| 3. |
- Szatmari, Peter, et al.
(författare)
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Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
- 2007
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:3, s. 319-328
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Tidskriftsartikel (refereegranskat)abstract
- Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,168 families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
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| 4. |
- Wilkinson, Cathy, 1973-, et al.
(författare)
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Social-ecological resilience : insights and issues for planning theory
- 2012
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Ingår i: Planning Theory. - : SAGE Publications. - 1473-0952 .- 1741-3052. ; 11:2, s. 148-169
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Tidskriftsartikel (refereegranskat)abstract
- With its origins in systems ecology and emerging interest in the inter-disciplinary examination of the governance of linked social-ecological systems, social-ecological resilience offers a field of scholarship of particular relevance for planning at a time when global ecological challenges require urgent attention. This article explores what new conceptual ground social-ecological resilience offers planning theory. I argue that at a time when planning theorists are calling for more attention to matters of substance alongside matters of process, social-ecological resilience provides a timely contribution, particularly given the minimal attention in planning theory scholarship to environmental and ecological considerations as a driving concern.
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| 5. |
- Wilkinson, Cathy, 1973-
(författare)
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Social-ecological resilience and planning: an interdisciplinary exploration
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Despite considerable expansion in the scope and function of the state with respect to environmental protection, the world’s biological diversity and ecosystem services continue to deteriorate. Finding ways to better govern human-nature relations in cities is an important part of addressing this decline. The aim of this thesis is to explore the potential of social-ecological resilience to inform urban governance in theory and practice, through a focus on strategic spatial planning. Resilience has become an increasingly important urban policy discourse and much hope is placed in its potential to improve urban governance. However, there is an acknowledged gap between social-ecological resilience as an ideal and the ability to govern towards it in practice. At the time this doctoral research commenced there had been no engagement with social-ecological resilience in the planning theory literature and minimal engagement by empirical planning research. It is to this gap the thesis contributes. Social-ecological resilience scholarship is found to offer planning theory a partly new way of understanding complex human-nature relations. This is relevant to calls by planning theorists for more attention to matters of substance, including ecological processes. With respect to practice, planners see potential for social-ecological resilience to critically inform strategic spatial planning, including through the framing of problems, tools for analysis/synthesis and governance options. There are also however, lessons for social-ecological resilience scholarship that emerge from the detailed empirical research which suggests that attention to the politics of the everyday activities of administrators, elected officials, planning officials, conservationists and citizens operating within the so-called ‘mangle of practice’ is critical to explaining the gap between the ideal of governing for urban resilience, and what happens in practice.
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| 6. |
- Wilkinson, Cathy, 1973-, et al.
(författare)
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Strategic navigation : in search of an adaptable mode of strategic spatial planning practice
- 2011
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Ingår i: Town planning review. - : Liverpool University Press. - 0041-0020 .- 1478-341X. ; 82:5, s. 595-613
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Tidskriftsartikel (refereegranskat)abstract
- In face of a dizzying pace of change, radical uncertainty and emergent policy effects there have been calls for more open, dynamic and adaptable alternatives to the modernist institutional legacy of strategic spatial planning practice. Here a case is explored where planners responsible for Melbourne's metropolitan planning sought to operationalise such an approach to strategic spatial planning following release of a new metropolitan strategy. They termed this approach 'strategic navigation'. Operationalisation of strategic navigation required: a reconceptualisation of the role of strategic planning; a codification of the subsequent organisational implications through the draft business planning process, including different priorities with respect to the knowledge and relationships, tools and practices that planners rely on to inform their situated judgement; and the identification and informal pursuit of leverageable strategies as a way to enact adaptability.
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| 7. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 9. |
- Deane, Colleen S., et al.
(författare)
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The acute transcriptional response to resistance exercise : impact of age and contraction mode
- 2019
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Ingår i: Aging. - : Impact Journals LLC. - 1945-4589. ; 11:7, s. 2111-2126
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Tidskriftsartikel (refereegranskat)abstract
- Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We used transcriptomics to compare age-related molecular responses to acute CON and ECC exercise. Eight young (21 +/- 1 y) and eight older (70 +/- 1 y) exercise-naive male volunteers had vastus lateralis biopsies collected at baseline and 5 h post unilateral CON and contralateral ECC exercise. RNA was subjected to next-generation sequencing and differentially expressed (DE) genes tested for pathway enrichment using Gene Ontology (GO). The young transcriptional response to CON and ECC was highly similar and older adults displayed moderate contraction-specific profiles, with no GO enrichment. Age-specific responses to ECC revealed 104 DE genes unique to young, and 170 DE genes in older muscle, with no GO enrichment. Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondria! respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.
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| 10. |
- Freitag, Daniel F., et al.
(författare)
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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
- 2015
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Ingår i: The Lancet Diabetes & Endocrinology. - 2213-8595. ; 3:4, s. 243-253
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Tidskriftsartikel (refereegranskat)abstract
- Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1 alpha and IL-1 beta); both alleles increase soluble IL-1Ra protein concentration. We compared effects on inflammation biomarkers of this genetic score with those of anakinra, the recombinant form of IL-1Ra, which has previously been studied in randomised trials of rheumatoid arthritis and other inflammatory disorders. In primary analyses, we investigated the score in relation to rheumatoid arthritis and four cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischaemic stroke, and abdominal aortic aneurysm; 453 411 total participants). In exploratory analyses, we studied the relation of the score to many disease traits and to 24 other disorders of proposed relevance to IL-1 signalling (746 171 total participants). Findings For each IL1RN minor allele inherited, serum concentrations of IL-1Ra increased by 0.22 SD (95% CI 0.18-0.25; 12.5%; p=9.3 x 10(-33)), concentrations of interleukin 6 decreased by 0.02 SD (-0.04 to -0.01; -1,7%; p=3.5 x 10(-3)), and concentrations of C-reactive protein decreased by 0.03 SD (-0.04 to -0.02; -3.4%; p=7.7 x 10(-14)). We noted the effects of the genetic score on these inflammation biomarkers to be directionally concordant with those of anakinra. The allele count of the genetic score had roughly log-linear, dose-dependent associations with both IL-1Ra concentration and risk of coronary heart disease. For people who carried four IL-1Ra-raising alleles, the odds ratio for coronary heart disease was 1.15 (1.08-1.22; p=1.8 x 10(-6)) compared with people who carried no IL-1Ra-raising alleles; the per-allele odds ratio for coronary heart disease was 1.03 (1.02-1.04; p=3.9 x 10(-10)). Perallele odds ratios were 0.97 (0.95-0.99; p=9.9 x 10(-4)) for rheumatoid arthritis, 0.99 (0.97-1.01; p=0.47) for type 2 diabetes, 1.00 (0.98-1.02; p=0.92) for ischaemic stroke, and 1.08 (1.04-1.12; p=1.8 x 10(-5)) for abdominal aortic aneurysm. In exploratory analyses, we observed per-allele increases in concentrations of proatherogenic lipids, including LDL-cholesterol, but no clear evidence of association for blood pressure, glycaemic traits, or any of the 24 other disorders studied. Modelling suggested that the observed increase in LDL-cholesterol could account for about a third of the association observed between the genetic score and increased coronary risk. Interpretation Human genetic data suggest that long-term dual IL-1 alpha/beta inhibition could increase cardiovascular risk and, conversely, reduce the risk of development of rheumatoid arthritis. The cardiovascular risk might, in part, be mediated through an increase in proatherogenic lipid concentrations. Copyright (C) The Interleukin 1 Genetics Consortium. Open Access article distributed under the terms of CC-BY-NC-ND.
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