| 1. |
- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 2. |
- Aronsson, Helena, et al.
(författare)
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Losses of phosphorus, potassium and nitrogen from horse manure left on the ground
- 2022
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Ingår i: Acta Agriculturae Scandinavica - Section B. - : Informa UK Limited. - 0906-4710 .- 1651-1913. ; 72:1, s. 893-901
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Tidskriftsartikel (refereegranskat)abstract
- In this five-month Swedish field study, we examined losses of nutrients from horse manure over time, in order to examine how regularly manure should be cleared from paddocks in order to minimise the risk of nutrient leaching. Small heaps of manure (400 g) were placed in open cylinders outdoors and samples (five replicates) were taken on 12 occasions from December 2020 to May 2021. The samples were analysed for weight, dry matter content and concentrations of total nitrogen (N), ammonium N, total phosphorus (P), water-extractable P (WEP), potassium (K) and carbon (C). There was a fast decline in P and K concentrations and a strong correlation between accumulated precipitation and losses from the manure into the soil. The mean reduction in total-P was 11 mg P kg−1 manure dry weight per mm accumulated precipitation. Manure N was retained in the manure over the five-month period. In conclusion, this study demonstrated high mobility of P and K, indicating a need for strategies for rapid removal of manure from paddocks. Daily removal of manure from paddocks used year-round would, approximately, save 1.7 kg P and 5.5 kg K per horse per year, which could be recycled to replace non-renewable mineral fertilisers.
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| 3. |
- Bengtsson, Jan, et al.
(författare)
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Agricultural intensification and biodiversity partitioning in European landscapes comparing plants, carabids, and birds
- 2011
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Ingår i: Ecological Applications. - : Wiley. - 1051-0761 .- 1939-5582. ; 21, s. 1772-1781
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Tidskriftsartikel (refereegranskat)abstract
- Effects of agricultural intensification (AI) on biodiversity are often assessed on the plot scale, although processes determining diversity also operate on larger spatial scales. Here, we analyzed the diversity of vascular plants, carabid beetles, and birds in agricultural landscapes in cereal crop fields at the field (n = 1350), farm (n = 270), and European-region (n = 9) scale. We partitioned diversity into its additive components alpha, beta, and gamma, and assessed the relative contribution of beta diversity to total species richness at each spatial scale. AI was determined using pesticide and fertilizer inputs, as well as tillage operations and categorized into low, medium, and high levels. As AI was not significantly related to landscape complexity, we could disentangle potential AI effects on local vs. landscape community homogenization. AI negatively affected the species richness of plants and birds, but not carabid beetles, at all spatial scales. Hence, local AI was closely correlated to beta diversity on larger scales up to the farm and region level, and thereby was an indicator of farm-and region-wide biodiversity losses. At the scale of farms (12.83-20.52%) and regions (68.34-80.18%), beta diversity accounted for the major part of the total species richness for all three taxa, indicating great dissimilarity in environmental conditions on larger spatial scales. For plants, relative importance of alpha diversity decreased with AI, while relative importance of beta diversity on the farm scale increased with AI for carabids and birds. Hence, and in contrast to our expectations, AI does not necessarily homogenize local communities, presumably due to the heterogeneity of farming practices. In conclusion, a more detailed understanding of AI effects on diversity patterns of various taxa and at multiple spatial scales would contribute to more efficient agri-environmental schemes in agroecosystems.
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| 4. |
- Bengtsson, Jan, et al.
(författare)
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Persistent negative effects of pesticides on biodiversity and biological control potential on European farmland
- 2010
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Ingår i: Basic and Applied Ecology. - : Elsevier BV. - 1439-1791 .- 1618-0089. ; 11, s. 97-105
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Tidskriftsartikel (refereegranskat)abstract
- During the last 50 years, agricultural intensification has caused many wild plant and animal species to go extinct regionally or nationally and has profoundly changed the functioning of agro-ecosystems. Agricultural intensification has many components, such as loss of landscape elements, enlarged farm and field sizes and larger inputs of fertilizer and pesticides. However, very little is known about the relative contribution of these variables to the large-scale negative effects on biodiversity. In this study, we disentangled the impacts of various components of agricultural intensification on species diversity of wild plants, carabids and ground-nesting farmland birds and on the biological control of aphids.In a Europe-wide study in eight West and East European countries, we found important negative effects of agricultural intensification on wild plant, carabid and bird species diversity and on the potential for biological pest control, as estimated from the number of aphids taken by predators. Of the 13 components of intensification we measured, use of insecticides and fungicides had consistent negative effects on biodiversity. Insecticides also reduced the biological control potential. Organic farming and other agri-environment schemes aiming to mitigate the negative effects of intensive farming on biodiversity did increase the diversity of wild plant and carabid species, but - contrary to our expectations - not the diversity of breeding birds.We conclude that despite decades of European policy to ban harmful pesticides, the negative effects of pesticides on wild plant and animal species persist, at the same time reducing the opportunities for biological pest control. If biodiversity is to be restored in Europe and opportunities are to be created for crop production utilizing biodiversity-based ecosystem services such as biological pest control, there must be a Europe-wide shift towards farming with minimal use of pesticides over large areas. (C) 2009 Gesellschaft fur Okologie. Published by Elsevier Gmbh. All rights reserved.
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| 5. |
- Bengtsson, Jan, et al.
(författare)
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The relationship between agricultural intensification and biological control: experimental tests across Europe
- 2011
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Ingår i: Ecological Applications. - : Wiley. - 1051-0761 .- 1939-5582. ; 21, s. 2187-2196
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Tidskriftsartikel (refereegranskat)abstract
- Agricultural intensification can affect biodiversity and related ecosystem services such as biological control, but large-scale experimental evidence is missing. We examined aphid pest populations in cereal fields under experimentally reduced densities of (1) ground-dwelling predators (-G), (2) vegetation-dwelling predators and parasitoids (-V), (3) a combination of (1) and (2) (-G-V),compared with open-fields (control), in contrasting landscapes with low vs. high levels of agricultural intensification (AI), and in five European regions. Aphid populations were 28%, 97%, and 199% higher in -G, -V, and -G -V treatments, respectively, compared to the open fields, indicating synergistic effects of both natural-enemy groups. Enhanced parasitoid : host and predator : prey ratios were related to reduced aphid population density and population growth. The relative importance of parasitoids and vegetation-dwelling predators greatly differed among European regions, and agricultural intensification affected biological control and aphid density only in some regions. This shows a changing role of species group identity in diverse enemy communities and a need to consider region-specific landscape management.
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| 6. |
- Caruso, Alexandro, et al.
(författare)
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Different patterns in species richness and community composition between trees, plants and epiphytic lichens in semi-natural pastures under agri-environment schemes
- 2015
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Ingår i: Biodiversity and Conservation. - : Springer Science and Business Media LLC. - 0960-3115 .- 1572-9710. ; 24, s. 1729-1742
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Tidskriftsartikel (refereegranskat)abstract
- Agri-environment schemes (AES) have been established to counteract negative effects of agricultural intensification on e.g. semi-natural pastures and meadows. The efficiency of most AESs have, however, been poorly evaluated. We evaluated the success of a Swedish AES for the management of semi-natural pastures by comparing species richness and composition of vascular plants (except trees), epiphytic lichens and trees among pastures receiving higher (high value pastures) and lower levels of AES paymens (general value pastures). There was no difference in the number of tree species among high and general value pastures, even though AES regulations allow a maximum of 60 and 100 trees/ha in general and high value pastures, respectively. High value pastures had, however, a higher number of plant and epiphytic lichen species than common value pastures. Moreover, a higher number of pasture specialist plant species were indicative of high value pastures than of general value pastures. No lichen species indicating high value pastures are associated with habitats with low canopy cover (such as e.g. pastures). Finally, tree identity was an important factor for explaining the number and composition of epiphytic lichen species. Our study highlights that species groups can respond differently to agri-environment schemes and other conservation measures. Even though the effects are the desired on the diversity of one assessed taxon, this is not always the case for non-target organism groups.
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| 7. |
- Flyen, Anne-Cathrine, et al.
(författare)
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Remediating Mining Landscapes
- 2022
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Ingår i: Resource Extraction and Arctic Communities: The New Extractivist Paradigm. - : Cambridge University Press. ; , s. 185-205
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter explores mining as a social process of continuous change into the future. Following new environmental legislation, environmental remediation and re-wilding are becoming practices of restoring landscapes altered by extraction. These are also political, social, and cultural processes involving multiple actors making choices. Remediation and re-wilding, still in an exploratory stage in the Arctic, demonstrate the entangled nature of sustainability. In order for extraction to become “sustainable” it is essential that governance has a focus on what is left when peak extraction is passed. If that is done in a hasty and irresponsible manner it will take a long time to heal “landscape scars” and other wounds that extraction has brought. The chapter focuses on the environmental remediation of two former mining sites – the Nautanen mine in Norrbotten in Sweden and the Lunckefjell mine and Sveagruvan on Svalbard – with very different contexts. At Lunckefjell, the wider framework was to safeguard Norwegian sovereignty on Svalbard. At Nautanen, remediation was limited to an attempt to make a profit from mining waste and eventually failed because of a conflict over responsibility.
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| 8. |
- Gagic, Vesna, et al.
(författare)
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Landscape complexity is not a major trigger of species richness and food web structure of European cereal aphid parasitoids
- 2015
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Ingår i: BioControl. - : Springer Science and Business Media LLC. - 1386-6141 .- 1573-8248. ; 60, s. 451-461
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Tidskriftsartikel (refereegranskat)abstract
- In fragmented farmland landscapes structural complexity and low agricultural intensification should decrease the abundance of crop aphids due to increased abundances and species diversity of aphid enemies, including hymenopteran parasitoids. Here we study the effects of landscape structure and agricultural intensification on parasitism rates, abundances, and species richness of aphids and their parasitoids in five different regions in Europe. While total aphid numbers did not differ significantly among regions, we observed marked differences between Scandinavian and central European sites with respect to the species composition of aphids and their parasitoids and parasitism rates. In the cross country comparison landscape complexity and agricultural intensification did not significantly affect total aphid densities, although we observed species-specific reactions to land use. We also observed a tendency towards increased parasitoid species richness at low agricultural intensification but not at high landscape structure.
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| 9. |
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| 10. |
- Hollestelle, Antoinette, et al.
(författare)
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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
- 2016
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Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 141:2, s. 386-401
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Tidskriftsartikel (refereegranskat)abstract
- Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. Methods Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). Results We found no association with risk of ovarian cancer (OR = 0.99, 95% CI 0.94-1.04, p = 0.74) or breast cancer (OR = 0.98, 95% CI 0.94-1.01, p = 0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR = 1.09, 95% CI 0.97-1.23, p = 0.14, breast cancer HR = 1.04, 95% CI 0.97-1.12, p = 0.27; BRCA2, ovarian cancer HR = 0.89, 95% CI 0.71-1.13, p = 0.34, breast cancer HR = 1.06, 95% CI 0.94-1.19, p = 0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR = 0.94, 95% CI 0.83-1.07, p = 0.38), breast cancer (HR = 0.96, 95% CI 0.87-1.06, p = 0.38), and all other previously-reported associations. Conclusions rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
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