| 1. |
- Singh, B., et al.
(författare)
-
Study of doubly strange systems using stored antiprotons
- 2016
-
Ingår i: Nuclear Physics A. - : Elsevier. - 0375-9474 .- 1873-1554. ; 954, s. 323-340
-
Tidskriftsartikel (refereegranskat)abstract
- Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the PANDA experiment at FAIR. For the first time, high resolution gamma-spectroscopy of doubly strange Lambda Lambda-hypernuclei will be performed, thus complementing measurements of ground state decays of Lambda Lambda-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Xi(-) -atoms will be feasible and even the production of Omega(-) -atoms will be within reach. The latter might open the door to the vertical bar S vertical bar = 3 world in strangeness nuclear physics, by the study of the hadronic Omega(-) -nucleus interaction. For the first time it will be possible to study the behavior of Xi(+) in nuclear systems under well controlled conditions.
|
|
| 2. |
- Cortese, S., et al.
(författare)
-
The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
- 2023
-
Ingår i: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634. ; 149
-
Tidskriftsartikel (refereegranskat)abstract
- We aimed to identify promising novel medications for child and adolescent mental health problems. We systematically searched https://clinicaltrials.gov/ and https://www.clinicaltrialsregister.eu/ (from 01/01/ 2010-08/23/2022) for phase 2 or 3 randomized controlled trials (RCTs) of medications without regulatory approval in the US, Europe or Asia, including also RCTs of dietary interventions/probiotics. Additionally, we searched phase 4 RCTs of agents targeting unlicensed indications for children/adolescents with mental health disorders. We retrieved 234 ongoing or completed RCTs, including 26 (11%) with positive findings on & GE; 1 primary outcome, 43 (18%) with negative/unavailable results on every primary outcome, and 165 (70%) without publicly available statistical results. The only two compounds with evidence of significant effects that
|
|
| 3. |
|
|
| 4. |
- Wohlfarth, C., et al.
(författare)
-
miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome
- 2017
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism (SNP) (rs201253747) c.*61 T > C within the 5-HT4 receptor gene HTR4 to be predominantly present in diarrhoea-IBS patients (IBS-D). It affects a binding site for the miR-16 family and miR-103/miR-107 within the isoforms HTR4b/i and putatively impairs HTR4 expression. Subsequent miRNA-profiling revealed downregulation of miR-16 and miR-103 in the jejunum of IBS-D patients correlating with symptoms. In vitro assays confirmed expression regulation via three 3'UTR binding sites. The novel isoform HTR4b_2 lacking two of the three miRNA binding sites escapes miR-16/103/107 regulation in SNP carriers. We provide the first evidence that HTR4 expression is fine-tuned by miRNAs, and that this regulation is impaired either by the SNP c.*61 T > C or by diminished levels of miR-16 and miR-103 suggesting that HTR4 might be involved in the development of IBS-D.
|
|
| 5. |
- Björck, S., et al.
(författare)
-
Synchronized terrestrial-atmospheric deglacial records around the North Atlantic.
- 1996
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 274:5290, s. 1155-1160
-
Tidskriftsartikel (refereegranskat)abstract
- On the basis of synchronization of three carbon-14 (C-14)-dated lacustrine sequences from Sweden With tree ring and ice core records, the absolute age of the Younger Dryas-Preboreal climatic shift was determined to be 11,450 to 11,390 +/- 80 years before the present. A 150-year-long cooling in the early Preboreal, associated with rising Delta(14)C values, is evident in all records and indicates an ocean ventilation change. This cooling is similar to earlier deglacial coolings, and box-model calculations suggest that they all may have been the result of increased freshwater forcing that inhibited the strength of the North Atlantic heat conveyor, although the Younger Dryas may have begun as an anomalous meltwater event.
|
|
| 6. |
|
|
| 7. |
- Goslar, T, et al.
(författare)
-
Variations of atmospheric C-14 concentrations over the Allerod-Younger Dryas transition
- 1999
-
Ingår i: CLIMATE DYNAMICS. - : SPRINGER VERLAG. - 0930-7575. ; 15:1, s. 29-42
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Highly variable atmospheric radiocarbon concentrations are a distinct feature during the last deglaciation. The synchronisation of two high-resolution AMS C-14-dated records, Lake Gosciaz, and a floating Late Weichselian glacial varve chronology at the Al
|
|
| 8. |
- Hammarlund, Dan, et al.
(författare)
-
Palaeolimnological and sedimentary responses to Holocene forest retreat in the Scandes Mountains, west-central Sweden
- 2004
-
Ingår i: Holocene. - : SAGE Publications. - 0959-6836 .- 1477-0911. ; 14:6, s. 862-876
-
Tidskriftsartikel (refereegranskat)abstract
- A suite of analyses was performed on sediments accumulated during the last 10 700 years in Lake Spaime, a small, hydrologically open water body in the modern alpine tundra zone of the Scandes Mountains, west-central Sweden. The study aimed to evaluate (1) the nature of climate changes that forced the late-Holocene lowering of altitudinal tree limit in the region, the timing of which is known from prior studies based on radiocarbon dating of subfossil wood, and (2) the impact of these vegetational changes on an aquatic ecosystem. Arboreal pollen and plant macrofossil data confirm the persistence of trees in the lake catchment at least from c. 9700 cal. BP until c. 3700 cal. BP. Although growing-season temperature is commonly believed to be the dominant factor driving boreal forest tree-limit variations in the region, a chironomid-based reconstruction of mean July air temperature suggests that local deforestation during the late Holocene was not accompanied by a significant cooling. The tree-limit retreat was more likely caused by increasing effective moisture and declining length of the growing season. The ecohydrological response of Lake Spaime to this combination of climate and vegetational changes included a decline in primary productivity, as indicated by an abrupt decrease in sediment organic matter content, while associated increases in organic delta(13)C, delta(15)N and C/N point to diminished fluxes and altered balance of catchment-derived nutrients following deforestation. The decline in aquatic productivity is also marked by a distinct change in the mineral magnetic properties, from a high magnetic concentration assemblage dominated by fine-grained magnetite of biogenic origin to one dominated by background levels of coarse-grained detrital magnetite.
|
|
| 9. |
|
|
| 10. |
|
|
