| 1. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Dolins, Sigma, 1985, et al.
(författare)
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Sharing anxiety is in the driver’s seat: Analyzing user acceptance of dynamic ridepooling and its implications for shared autonomous mobility
- 2021
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 13:14
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Tidskriftsartikel (refereegranskat)abstract
- As connected, electric, and autonomous vehicle (AV) services are developed for cities, the research is conclusive that the use of these services must be shared to achieve maximum efficiency. Yet, few agencies have prioritised designing an AV system that focuses on dynamic ridepooling, and there remains a gap in the understanding of what makes people willing to share their rides. However, in 2017, the Australian transport authority Transport for New South Wales launched over a dozen trials for on-demand, shared public transport, including AVs. In this paper, we investigate the user willingness-to-share, based on experiences from one of these trials. Four focus groups (19 participants in total) were held in New South Wales with active users of either the trialled on-demand dynamic ridepooling service (Keoride) or commercial ridepooling (UberPool). Through thematic analysis of the focus group conversations, the cost, comfort, convenience, safety, community culture, and trust in authority emerged as factors that influenced the willingness-to-share. When presented with driverless scenarios, the focus group participants had significant concerns about the unknown behaviour of their co-passengers, revealing sharing anxiety as a significant barrier to the adoption of shared AVs. This paper identifies previously disregarded factors that influence the adoption of AVs and dynamic ridepooling and offers insights on how potential users’ sharing anxiety can be mitigated.
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| 3. |
- Dolins, Sigma, et al.
(författare)
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The ‘sharing trap’ : A case study of societal and stakeholder readiness for on-demand and autonomous public transport in New South Wales, Australia
- 2021
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 13:17
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Tidskriftsartikel (refereegranskat)abstract
- Focus groups on shared, autonomous vehicles (SAVs) in New South Wales expressed “sharing anxiety”—an intense concern about the prospect of sharing their mobility journey with strangers, without a driver or authority figure present. This presents a significant barrier to the acceptance of SAVs, particularly autonomous public and on-demand transport (ODT), which is a major focus for Transport for New South Wales (TfNSW). Given this potential barrier, we interviewed (N = 13) operators, academics, and regulators with TfNSW to assess their role and abilities in overcoming sharing anxiety. However, our findings revealed a relative lack of awareness from experts in the mobility industry about the existence of sharing anxiety in users, suggesting additional barriers to adoption. We make suggestions for policy considerations for stakeholders that could mitigate sharing anxiety: promoting dynamic ridepooling products in commercial services, using tax breaks as incentivization; requiring ODT services and operators in jurisdiction to use a standardized, unified interface for users (“single-app”); shared, on-demand transport services likely need longer incubation/pilot periods in order for the sharing behavior to become culturally established. We conclude with a reflection on how COVID-19 has impacted the development of shared mobility and suggest further exploration in policy implementation. © 2021 by the authors.
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| 4. |
- Hensher, David, et al.
(författare)
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Understanding MaaS: Past, Present and Future
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Daily references to the changing landscape in the provision of passenger transport services is made in the transport literature, including grey material. Mobility as a Service (MaaS) is the acronym which appears to have caught the imagination of technology providers with promises of a new era of passenger transport whereby assets need not be owned and services can be bought at the point of need. It is the technological developments which have spearheaded the new understanding of MaaS. MaaS has evolved into a concept that integrates public and private transport services to provide one- stop access through a common interface. MaaS is at the centre of the popular view on future collaborative and connected mobility. For transport policy, MaaS is seen as a way to reduce car traffic, and its negative externalities, by enabling citizens to satisfy their mobility needs without having to own assets such as automobiles, either conventional or (in the future) self-driving. MaaS also opens new choices for non-car owning citizens who previously had limited transport options, making some of them socially excluded. Whilst definitions vary, the concept of MaaS has several dimensions: in the form of a smart app and in real-time, it provides mobility services using multimodal options, through a sophisticated journey planner that provides the user with multiple customised options and offers the opportunity for payment either at the point of use or with a pre-purchased mobility bundle. This single platform is envisaged to eventually be transferable around the world from city to city and region to region and also to remain pervasive to the user by working and monitoring the journey in real-time and providing options for recovery in the case of disruption, and with an aspiration to support public equity objectives. MaaS has also received considerable attention in recent years from decision-makers (for instance, the Finnish government has implemented new transport regulations intended to facilitate MaaS developments) and practitioners (examples of MaaS start-ups include MaaS Global in Finland, EC2B in Sweden and Moovel in Germany) as well as researchers (e.g., Hensher and Mulley (2019) Hensher, 2017; Jittrapirom, 2017; Sochor et al., 2016; Wong et al., 2019; Mulley, 2017). Still, the knowledge of MaaS is nascent, trials for the most part have not been thoroughly evaluated and the evidence for the mobility and societal benefits of MaaS have yet to be confirmed. The paper is structured as follows. The next section provides the literature context that underpins the part of the title of this paper relating to the ‘Past’. This is followed by a section detailing the present in terms of a current MaaS trial in Sydney, New South Wales, designed to provide another ‘data point’ in our current understanding of MaaS. The penultimate section looks to the future and the challenges ahead by identifying some key questions critical to the development of MaaS. The final section concludes.
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| 5. |
- Hensher, David, et al.
(författare)
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Understanding Mobility as a Service (MaaS): Past, Present and Future
- 2020
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- The widespread adoption of smartphones, ridesharing and carsharing have disrupted the transport sector. In cities around the world, new mobility services are both welcomed and challenged by regulators and incumbent operators. Mobility as a Service (MaaS), an ecosystem designed to deliver collaborative and connected mobility services in a society increasingly embracing a sharing culture, is at the center of this disruption. Understanding Mobility as a Service (MaaS): Past, Present and Future examines such topics as: - How likely MaaS will be implemented in one digital platform app - Whether MaaS will look the same in all countries - The role multi-modal contract brokers play - Mobility regulations and pricing models - MaaS trials, their impacts and consequences Written by the leading thinkers in the field for researchers, practitioners, and policy makers, Understanding Mobility as a Service (MaaS): Past, Present and Future serves as a single source on all the current and evolving developments, debates, and challenges.
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