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- Björkqvist, Maria, et al.
(författare)
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
- 2008
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205, s. 1869-1877
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Tidskriftsartikel (refereegranskat)abstract
- Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread evidence of innate immune activation detectable in plasma throughout the course of HD. Interleukin 6 levels were increased in HD gene carriers with a mean of 16 years before the predicted onset of clinical symptoms. To our knowledge, this is the earliest plasma abnormality identified in HD. Monocytes from HD subjects expressed mutant huntingtin and were pathologically hyperactive in response to stimulation, suggesting that the mutant protein triggers a cell-autonomous immune activation. A similar pattern was seen in macrophages and microglia from HD mouse models, and the cerebrospinal fluid and striatum of HD patients exhibited abnormal immune activation, suggesting that immune dysfunction plays a role in brain pathology. Collectively, our data suggest parallel central nervous system and peripheral pathogenic pathways of immune activation in HD.
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- Davis, Paul A., et al.
(författare)
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Better out than in : The influence of anger regulation on physical performance
- 2010
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Ingår i: Personality and Individual Differences. - : Elsevier. - 0191-8869 .- 1873-3549. ; 49:5, s. 457-460
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Tidskriftsartikel (refereegranskat)abstract
- We examined the influence of individual differences in anger regulation as potential moderators of the anger–performance relationship. Extending Lazarus’s (1991, 2000a) cognitive–motivational–relational theory of emotion, we investigated the influence of trait anger and the anger regulation styles of anger-in and anger-out on the performance of a physical task. As hypothesized, trait anger and anger-out were positively associated with anger-derived performance enhancement on a peak force task; anger-in significantly inhibited the trait anger–performance relationship. Results are discussed in relation to Lazarus’s cognitive–motivational–relational theory and future research directions are offered.
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- Davis, Paul A., et al.
(författare)
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Written Emotional Disclosure can Promote Athletes’ Mental Health and Performance Readiness during the COVID-19 Pandemic
- 2020
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Ingår i: Frontiers in Psychology. - : Frontiers Media S.A.. - 1664-1078. ; 11
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Forskningsöversikt (refereegranskat)abstract
- The widespread effects of the COVID-19 pandemic have negatively impacted upon many athletes’ mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes’ emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes’ social and emotional support. Written Emotional Disclosure has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The expressive writing protocol has been used to a limited extent in the context of sport, and predominantly in support of athletes’ emotional processing during injury rehabilitation. We propose that Written Emotional Disclosure offers an evidence-based treatment that can promote athletes’ mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of Written Emotional Disclosure; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using Written Emotional Disclosure to support athletes during the COVID-19 pandemic are presented.
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