| 1. |
- Larhammar, Dan, et al.
(författare)
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Evolution of neuropeptide Y and its receptors
- 1997
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Ingår i: Advances in Comparative Endocrinology. - : XIIIth Intl Congress of Comparative Endocrinology. ; , s. 551-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Rodriguez, L. , V, et al.
(författare)
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Doubly-magic character of Sn-132 studied via electromagnetic moments of( 13)(3)Sn
- 2020
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 102:5
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Tidskriftsartikel (refereegranskat)abstract
- We report the first measurement of the magnetic dipole and electric quadrupole moment of the exotic nucleus Sn-133 by high-resolution laser spectroscopy at ISOLDE/CERN. These, in combination with state-of-the-art shell-model calculations, demonstrate the single-particle character of the ground state of this short-lived isotope and, hence, the doubly-magic character of its immediate neighbor Sn-132. The trend of the electromagnetic moments along the N = 83 isotonic chain, now enriched with the values of tin, are discussed on the basis of realistic shell-model calculations.
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| 3. |
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| 4. |
- Anderson, Per, et al.
(författare)
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Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells
- 2003
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Ingår i: International Immunology. - : Oxford University Press (OUP). - 1460-2377. ; 15:11, s. 1309-1317
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Tidskriftsartikel (refereegranskat)abstract
- Cytokines direct the differentiation of naive CD4(+) T cells into either IFN-gamma-producing T(h)1 cells or IL-4-producing T(h)2 cells. In this study, we analyzed the activation of signal transducer and activator of transcription (STAT)1, STAT3 and STAT5 (together with STAT4 and STAT6), and the expression of the recently identified suppressor of cytokine signalling (SOCS) proteins, in differentiated T(h)1 and T(h)2 cells, both before and after re-stimulation with anti-CD3 and anti-CD28. In addition to the polarized activation of STAT4 in T(h)1 cells and STAT6 in T(h)2 cells, we found that STAT3 and STAT5 are selectively activated in T(h)1 cells after differentiation. This activation of STAT3 and STAT5 was maintained after TCR re-stimulation. The selective activation of STAT3 and STAT5 in T(h)1 cells was associated with differential induction of SOCS molecules. After restimulation, SOCS1 expression was significantly increased in T(h)2 cells, but not in T(h)1 and nonpolarized 'T-h' cells. Additionally, the level of CIS was higher in T(h)2 cells compared with T(h)1 and T-h cells. In contrast, the expression of SOCS3 was higher in T(h)1 cells. The differential induction of SOCS proteins was paralleled by the differential expression of cytokines in re-stimulated T(h)1 and T(h)2 cells (IFN-gamma and IL-4/IL-13 respectively). Our results suggests that STAT3 and STAT5, possibly regulated by the SOCS proteins, may play a role in the differentiation of T-h cells, and in the maintenance of the T(h)1 and T(h)2 phenotype.
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| 5. |
- Anderson, Per, et al.
(författare)
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IL-2 overcomes the unresponsiveness but fails to reverse the regulatory function of antigen-induced T regulatory cells
- 2005
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Ingår i: Journal of Immunology. - 1550-6606. ; 174:1, s. 310-319
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Tidskriftsartikel (refereegranskat)abstract
- Intranasal administration of peptide Acl-9[4Y], based on the N-terminal epitope of myelin basic protein, can induce CD4(+) T cell tolerance, and suppress experimental autoimmune encephalomyelitis induction. The peptide-induced regulatory T (PI-T-Reg) cells failed to produce IL-2, but expressed IL-10 in response to Ag and could suppress naive T cell responses in vitro. Analysis of Jak-STAT signaling pathways revealed that the activation of Jak1, STAT3, and STAT5 were induced in tolerant T cells after Ag stimulation in vivo. In addition, the expression of suppressor of cytokine signaling 3 was induced in tolerant T cells, suggesting that cytokines regulate the tolerant state of the PI-T-Reg cells. Stimulation of PI-T-Reg cells in vitro with IL-10 induced Jak1 and STAT3 activation, but not STAT5, suggesting that IL-10 is important, but not the only cytokine involved in the development of T cell tolerance. Although IL-2 expression was deficient, stimulation with IL-2 in vitro induced Jak1 and STAT5 activation in PI-T-Reg cells, restored their proliferative response to antigenic stimulation, and abrogated PI-T-Reg-mediated suppression in vitro. However, the addition of IL-2 could not suppress IL-10 expression, and the IL-2 gene remained inactive. After withdrawal of IL-2, the PI-T-Reg cells regained their nonproliferative state and suppressive ability. These results underline the ability of the immune system to maintain tolerance to autoantigens, but at the same time having the ability to overcome the suppressive phenotype of tolerant T cells by cytokines, such as IL-2, during the protective immune response to infection.
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| 6. |
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| 7. |
- Hussein, T., et al.
(författare)
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Evaluation and modeling of the size fractionated aerosol particle number concentration measurements nearby a major road in Helsinki - Part II : Aerosol measurements within the SAPPHIRE project
- 2007
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Ingår i: Atmospheric Chemistry And Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 7:15, s. 4081-4094
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Tidskriftsartikel (refereegranskat)abstract
- This study presents an evaluation and modeling exercise of the size fractionated aerosol particle number concentrations measured nearby a major road in Helsinki during 23 August-19 September 2003 and 14 January-11 February 2004. The available information also included electronic traffic counts, on-site meteorological measurements, and urban background particle number size distribution measurement. The ultrafine particle (UFP, diameter < 100 nm) number concentrations at the roadside site were approximately an order of magnitude higher than those at the urban background site during daytime and downwind conditions. Both the modal structure analysis of the particle number size distributions and the statistical correlation between the traffic density and the UFP number concentrations indicate that the UFP were evidently from traffic related emissions. The modeling exercise included the evolution of the particle number size distribution nearby the road during downwind conditions. The model simulation results revealed that the evaluation of the emission factors of aerosol particles might not be valid for the same site during different time.
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