| 1. |
- Lin, Xiaojing, et al.
(författare)
-
Metal-enriched Neutral Gas Reservoir around a Strongly Lensed Low-mass Galaxy at z = 4 Identified by JWST/NIRISS and VLT/MUSE
- 2023
-
Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 944:2
-
Tidskriftsartikel (refereegranskat)abstract
- Direct observations of low-mass, low-metallicity galaxies at z ≳ 4 provide an indispensable opportunity for detailed inspection of the ionization radiation, gas flow, and metal enrichment in sources similar to those that reionized the universe. Combining the James Webb Space Telescope (JWST), Very Large Telescope/MUSE, and Atacama Large Millimeter/submillimeter Array, we present detailed observations of a strongly lensed, low-mass (≈107.6 M ⊙) galaxy at z = 3.98 (also see Vanzella et al.). We identify strong narrow nebular emission, including C iv λ λ1548, 1550, He ii λ1640, O iii] λ λ1661, 1666, [Ne iii] λ3868, [O ii] λ3727, and the Balmer series of hydrogen from this galaxy, indicating a metal-poor H ii region (≲0.12 Z ⊙) powered by massive stars. Further, we detect a metal-enriched damped Lyα system (DLA) associated with the galaxy with the H i column density of N H I ≈ 1021.8 cm−2. The metallicity of the associated DLA may reach the supersolar metallicity (≳Z ⊙). Moreover, thanks to JWST and gravitational lensing, we present the resolved UV slope (β) map at the spatial resolution of ≈100 pc at z = 4, with steep UV slopes reaching β ≈ −2.5 around three star-forming clumps. Combining with low-redshift analogs, our observations suggest that low-mass, low-metallicity galaxies, which dominate reionization, could be surrounded by a high covering fraction of the metal-enriched, neutral-gaseous clouds. This implies that the metal enrichment of low-mass galaxies is highly efficient, and further supports that in low-mass galaxies, only a small fraction of ionizing radiation can escape through the interstellar or circumgalactic channels with low-column-density neutral gas.
|
|
| 2. |
- Lu, Quanming, et al.
(författare)
-
Features of separatrix regions in magnetic reconnection : Comparison of 2-D particle-in-cell simulations and Cluster observations
- 2010
-
Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 115:11
-
Tidskriftsartikel (refereegranskat)abstract
- In collisionless magnetic reconnection, the in-plane Hall currents are carried mainly by the magnetized electrons. The in-plane Hall currents are directed toward the X line along the magnetic field lines just inside the separatrices and away from the X line along the separatrices. Such a current system leads to the quadrupole out-of-plane magnetic field with the peaks between the regions carrying the in-plane currents. Simultaneously, the electron flow toward the X line along the separatrices causes electron density depletions along the separatrices. In this paper, the features of separatrix regions in magnetic reconnection and the relations between the electron density depletions and the out-of-plane magnetic field are investigated with both two-dimensional particle-in-cell simulations and Cluster observations. We conclude that the electron density depletions are formed because of the magnetic mirror, and they are outside the peaks of the out-of-plane magnetic field. Such a theoretical prediction is confirmed by both simulations and observations.
|
|
| 3. |
- Ren, Weicheng, et al.
(författare)
-
Genetic and transcriptomic analyses of diffuse large B-cell lymphoma patients with poor outcomes within two years of diagnosis
- 2024
-
Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 38:2, s. 438-441
-
Tidskriftsartikel (refereegranskat)abstract
- Despite the improvements in clinical outcomes for DLBCL, a significant proportion of patients still face challenges with refractory/relapsed (R/R) disease after receiving first-line R-CHOP treatment. To further elucidate the underlying mechanism of R/R disease and to develop methods for identifying patients at risk of early disease progression, we integrated clinical, genetic and transcriptomic data derived from 2805 R-CHOP-treated patients from seven independent cohorts. Among these, 887 patients exhibited R/R disease within two years (poor outcome), and 1918 patients remained in remission at two years (good outcome). Our analysis identified four preferentially mutated genes (TP53, MYD88, SPEN, MYC) in the untreated (diagnostic) tumor samples from patients with poor outcomes. Furthermore, transcriptomic analysis revealed a distinct gene expression pattern linked to poor outcomes, affecting pathways involved in cell adhesion/migration, T-cell activation/regulation, PI3K, and NF-kappa B signaling. Moreover, we developed and validated a 24-gene expression score as an independent prognostic predictor for treatment outcomes. This score also demonstrated efficacy in further stratifying high-risk patients when integrated with existing genetic or cell-of-origin subtypes, including the unclassified cases in these models. Finally, based on these findings, we developed an online analysis tool (https://lymphprog.serve.scilifelab.se/app/lymphprog) that can be used for prognostic prediction for DLBCL patients.
|
|
| 4. |
- Wang, Rongsheng, et al.
(författare)
-
Observation of double layer in the separatrix region during magnetic reconnection
- 2014
-
Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:14, s. 4851-4858
-
Tidskriftsartikel (refereegranskat)abstract
- We present in situ observation of double layer (DL) and associated electron measurement in the subspin time resolution in the separatrix region during reconnection for the first time. The DL is inferred to propagate away from the X line at a velocity of about ion acoustic speed and the parallel electric field carried by the DL can reach -20 mV/m. The electron displays a beam distribution inside the DL and streams toward the X line with a local electron Alfven velocity. A series of electron holes moving toward the X line are observed in the wake of the DL. The identification of multiple similar DLs indicates that they are persistently produced and therefore might play an important role in energy conversion during reconnection. The observation suggests that energy dissipation during reconnection can occur in any region where the DL can reach.
|
|
