SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wu QL) "

Sökning: WFRF:(Wu QL)

  • Resultat 1-10 av 19
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Hamerlik, P, et al. (författare)
  • Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
  • 2012
  • Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 209:3, s. 507-520
  • Tidskriftsartikel (refereegranskat)abstract
    • Although vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) is traditionally regarded as an endothelial cell protein, evidence suggests that VEGFRs may be expressed by cancer cells. Glioblastoma multiforme (GBM) is a lethal cancer characterized by florid vascularization and aberrantly elevated VEGF. Antiangiogenic therapy with the humanized VEGF antibody bevacizumab reduces GBM tumor growth; however, the clinical benefits are transient and invariably followed by tumor recurrence. In this study, we show that VEGFR2 is preferentially expressed on the cell surface of the CD133+ human glioma stem-like cells (GSCs), whose viability, self-renewal, and tumorigenicity rely, at least in part, on signaling through the VEGF-VEGFR2–Neuropilin-1 (NRP1) axis. We find that the limited impact of bevacizumab-mediated VEGF blockage may reflect ongoing autocrine signaling through VEGF–VEGFR2–NRP1, which is associated with VEGFR2–NRP1 recycling and a pool of active VEGFR2 within a cytosolic compartment of a subset of human GBM cells. Whereas bevacizumab failed to inhibit prosurvival effects of VEGFR2-mediated signaling, GSC viability under unperturbed or radiation-evoked stress conditions was attenuated by direct inhibition of VEGFR2 tyrosine kinase activity and/or shRNA-mediated knockdown of VEGFR2 or NRP1. We propose that direct inhibition of VEGFR2 kinase may block the highly dynamic VEGF–VEGFR2–NRP1 pathway and inspire a GBM treatment strategy to complement the currently prevalent ligand neutralization approach.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 19
Typ av publikation
tidskriftsartikel (19)
Typ av innehåll
refereegranskat (19)
Författare/redaktör
ERNBERG, I (5)
Li, YH (4)
Zhang, Y. (2)
Sun, J. (2)
Cheng, G. (2)
Agerberth, B (2)
visa fler...
Wang, HY (2)
Huang, LX (2)
Bai, Y. (1)
Wang, X. (1)
Yang, Y. (1)
Zhang, L. (1)
Zhou, L. (1)
Zhuang, X. (1)
Xie, Y. (1)
Hussain, N. (1)
Wu, Z. (1)
Das, S. (1)
Li, Q. (1)
Winblad, B (1)
Xu, Y. (1)
Lee, M (1)
Wang, JY (1)
Zhang, YQ (1)
Xu, W (1)
Chen, J. (1)
Huang, Z. (1)
Lu, Y (1)
Jin, H. (1)
Tian, Z. (1)
Holmdahl, R (1)
Xia, J. (1)
Xu, J (1)
Wang, B. (1)
Liu, F. (1)
Sun, F (1)
Han, Y (1)
Chen, F (1)
Wu, J (1)
Liao, J (1)
Wang, SF (1)
Ruas, JL (1)
Jannig, PR (1)
Harris, R (1)
Zhang, XL (1)
Chen, YJ (1)
Liu, YJ (1)
Dai, W (1)
Wang, XS (1)
Liu, P. (1)
visa färre...
Lärosäte
Karolinska Institutet (19)
Språk
Engelska (19)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy