| 1. |
- Kottyan, Leah C., et al.
(författare)
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The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
- 2015
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:2, s. 582-596
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Tidskriftsartikel (refereegranskat)abstract
- Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved separate associations in the IRF5 promoter (all ancestries) and with an extended European haplotype. We captured 3230 IRF5-TNPO3 high-quality, common variants across 5 ethnicities in 8395 SLE cases and 7367 controls. The genetic effect from the IRF5 promoter can be explained by any one of four variants in 5.7 kb (P-valuemeta = 6 × 10(-49); OR = 1.38-1.97). The second genetic effect spanned an 85.5-kb, 24-variant haplotype that included the genes IRF5 and TNPO3 (P-valuesEU = 10(-27)-10(-32), OR = 1.7-1.81). Many variants at the IRF5 locus with previously assigned biological function are not members of either final credible set of potential causal variants identified herein. In addition to the known biologically functional variants, we demonstrated that the risk allele of rs4728142, a variant in the promoter among the lowest frequentist probability and highest Bayesian posterior probability, was correlated with IRF5 expression and differentially binds the transcription factor ZBTB3. Our analytical strategy provides a novel framework for future studies aimed at dissecting etiological genetic effects. Finally, both SLE elements of the statistical model appear to operate in Sjögrens syndrome and systemic sclerosis whereas only the IRF5-TNPO3 gene-spanning haplotype is associated with primary biliary cirrhosis, demonstrating the nuance of similarity and difference in autoimmune disease risk mechanisms at IRF5-TNPO3.
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| 2. |
- Li, Yibei, et al.
(författare)
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A Duality-Based Approach to Inverse Kalman Filtering
- 2023
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Ingår i: 22nd IFAC World Congress Yokohama, Japan, July 9-14, 2023. - : Elsevier BV. ; , s. 10258-10263
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Konferensbidrag (refereegranskat)abstract
- In this paper, the inverse Kalman filtering problem is addressed using a duality-based framework, where certain statistical properties of uncertainties in a dynamical model are recovered from observations of its posterior estimates. The duality relation in inverse filtering and inverse optimal control is established. It is shown that the inverse Kalman filtering problem can be solved using results from a well-posed inverse linear quadratic regulator. Identifiability of the considered inverse filtering model is proved and a unique covariance matrix is recovered by a least squares estimator, which is also shown to be statistically consistent. Effectiveness of the proposed methods is illustrated by numerical simulations.
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| 3. |
- Li, Yibei, et al.
(författare)
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Inverse Kalman Filtering for Systems with Correlated Noises
- 2023
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Ingår i: 2023 62nd IEEE Conference on Decision and Control, CDC 2023. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 3626-3631
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Konferensbidrag (refereegranskat)abstract
- This paper focuses on two inverse problems of the Kalman filter in which the process and measurement noises are correlated. The unknown covariance matrix in a stochastic system is reconstructed from observations of its posterior beliefs. For the standard inverse Kalman filtering problem, a novel duality-based formulation is proposed, where a well-defined inverse optimal control (IOC) problem is solved instead. Identifiability of the underlying model is proved, and a least squares estimator is designed that is statistically consistent. The time-invariant case using the steady-state Kalman gain is further studied. Since this inverse problem is ill-posed, a canonical class of covariance matrices is constructed, which can be uniquely identified from the dataset with asymptotic convergence. Finally, the performances of the proposed methods are illustrated by numerical examples.
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| 4. |
- Li, Yibei, et al.
(författare)
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Inverse Kalman filtering problems for discrete-time systems
- 2024
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Ingår i: Automatica. - : Elsevier BV. - 0005-1098 .- 1873-2836. ; 163
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, several inverse Kalman filtering problems are addressed, where unknown parameters and/or inputs in a filtering model are reconstructed from observations of the posterior estimates that can be noisy or incomplete. In particular, duality in inverse filtering and inverse optimal control is studied. It is shown that identifiability and solvability of the inverse Kalman filtering is closely related to that of an inverse linear quadratic regulator (LQR). Covariance matrices of model uncertainties are estimated by solving a well-posed inverse LQR problem. Identifiability of the considered inverse filtering models is established and least squares estimators are designed to be statistically consistent. In addition, algorithms are proposed to reconstruct the unknown sensor parameters as well as raw sensor measurements. Effectiveness and efficiency of the proposed methods are illustrated by numerical simulations.
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| 5. |
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| 6. |
- Tian, Chen, et al.
(författare)
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Functional Failure Behavior of Submerged Entry Nozzle during the Continuous Casting Process of the Bearing Steel GCr15
- 2024
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Ingår i: Steel Research International. - : John Wiley & Sons. - 1611-3683 .- 1869-344X.
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Tidskriftsartikel (refereegranskat)abstract
- The submerged entry nozzle (SEN) is an indispensable functional structural ceramic in the current continuous casting production. The stability and safety of the SEN is very important during the casting process. In this article, the functional failure of the SEN during the continuous casting process of the bearing steel GCr15 is studied. The results show that the functional failure of the SEN during the bearing steel GCr15 casting process is caused by the clogging inside the SEN which is led by the low cleanliness and the high impurities n the molten steel. The clogging in the SEN can be divided into solidified steel area, loose area, dense area, and surface area. To improve the castability of bearing steel or other high-cleanliness steel, it is necessary to strengthen the refining process and treatment effect, strengthen the sealing and the effect of the protective casting of the molten steel, and moderate optimization of nozzle materials or the application of external fields on the SEN.
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| 7. |
- Waikar, Sushrut S, et al.
(författare)
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Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies
- 2016
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 31:9, s. 1460-1470
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The primary biomarkers used to define CKD are serum creatinine and albuminuria. These biomarkers have directed focus on the filtration and barrier functions of the kidney glomerulus even though albuminuria results from tubule dysfunction as well. Given that proximal tubules make up ∼90% of kidney cortical mass, we evaluated whether a sensitive and specific marker of proximal tubule injury, urinary kidney injury molecule-1 (KIM-1), is elevated in individuals with CKD or with risk factors for CKD.METHODS: We measured urinary KIM-1 in participants of five cohort studies from the USA and Sweden. Participants had a wide range of kidney function and were racially and ethnically diverse. Multivariable linear regression models were used to test the association of urinary KIM-1 with demographic, clinical and laboratory values.RESULTS: In pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {β = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [β = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)]. Urinary KIM-1 levels were higher in current smokers, lower in blacks than nonblacks and lower in users versus nonusers of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.CONCLUSION: Proximal tubule injury appears to be an integral and measurable element of multiple stages of CKD.
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| 8. |
- Wang, Sifan, et al.
(författare)
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Fire carbon emissions over Equatorial Asia reduced by shortened dry seasons
- 2023
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Ingår i: npj Climate and Atmospheric Science. - 2397-3722. ; 6:1
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Tidskriftsartikel (refereegranskat)abstract
- Fire carbon emissions over Equatorial Asia (EQAS) play a critical role in the global carbon cycle. Most regional fire emissions (89.0%) occur in the dry season, but how changes in the dry-season length affect the fire emissions remains poorly understood. Here we show that, the length of the EQAS dry season has decreased significantly during 1979–2021, and the delayed dry season onset (5.4 ± 1.6 (± one standard error) days decade−1) due to increased precipitation (36.4 ± 9.1 mm decade−1) in the early dry season is the main reason. The dry season length is strongly correlated with the length of the fire season. Increased precipitation during the early dry season led to a significant reduction (May: −0.7 ± 0.4 Tg C decade−1; August: −12.9 ± 6.7 Tg C decade−1) in fire carbon emissions during the early and peak fire season. Climate models from the Coupled Model Intercomparison Project Phase 6 project a continued decline in future dry season length in EQAS under medium and high-emission scenarios, implying further reductions in fire carbon emissions.
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| 9. |
- Wang, Weixi, et al.
(författare)
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BIM Information Integration Based VR Modeling in Digital Twins in Industry 5.0
- 2022
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Ingår i: Journal of Industrial Information Integration. - : ELSEVIER. - 2467-964X .- 2452-414X. ; 28
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to improve the efficiency of construction efficiency to ensure the infrastructure needs of urban development. Targeting at realizing the intelligent manufacturing of buildings, the digital twins are applied to all stages of building construction, and the three-dimensional (3D) modeling is implemented. A digital twins framework in the construction field is constructed based on the building information modeling (BIM). From physical construction site entity modeling (PCSE modeling) and digital twins virtual body modeling (DTVB modeling) to virtual and real interaction modeling (VRI modeling), the digital twins process is fully applied to the various stages of building construction. The performance of the method proposed is further verified through the analysis of specific data. It is found that the model proposed shows better performance on the same platform and node compared with other models, and it shows the best scalability in the iterative calculation test on the Flink platform through efficient memory management and incremental iteration mechanism. In addition, the model has a delay of less than 100 milliseconds: in the Sleep scenario, the system delay of the latest model is about 5 times that of on the Flink, and the system interruption probability will firstly decrease and then increase when the time division factor (TDF) is increased. This study provides important reference value for the intelligent development of the construction industry and the high-quality development of buildings.
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| 10. |
- Xie, Maomao, et al.
(författare)
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Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles
- 2023
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:17
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Forskningsöversikt (refereegranskat)abstract
- Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.
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