| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Gao, Hong, et al.
(författare)
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The landscape of tolerated genetic variation in humans and primates
- 2023
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6648
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Tidskriftsartikel (refereegranskat)abstract
- Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole-genome sequencing data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these variants can be inferred to have nondeleterious effects in humans based on their presence at high allele frequencies in other primate populations. We use this resource to classify 6% of all possible human protein-altering variants as likely benign and impute the pathogenicity of the remaining 94% of variants with deep learning, achieving state-of-the-art accuracy for diagnosing pathogenic variants in patients with genetic diseases.
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| 3. |
- Liu, Yang, et al.
(författare)
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Investigation on residual stress evolution in nickel-based alloy affected by multiple cutting operations
- 2021
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Ingår i: Journal of Manufacturing Processes. - : Elsevier BV. - 1526-6125. ; 68, s. 818-833
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Tidskriftsartikel (refereegranskat)abstract
- Machining-induced residual stresses in a part can significantly influence its performance and service time. It is common that the final surface of the part is produced after multiple cuts in the machining process. In multiple cuts, the previous cuts could often generate accumulated strain/stress and temperature on the part surface. These accumulated strain/stress and temperature will be brought to the subsequent cut or final cut and continuously affect the cutting forces, process temperatures, deformation zones, etc. in subsequent cut, and eventually affect the final residual stresses on the part. This paper reports on a joint experimental and numerical investigation to explore the influence of previous cuts on surface residual stresses with consideration of cutting parameters, cutting procedure, and tool geometries in multiple cut of Inconel 718 alloy. Coupled Eulerian and Lagrangian (CEL) formulation is used in a two/three-cuts numerical model. The loading cycles of the selected material nodes are characterised based on isotropic constitutive model (Johnson-Cook model) to analyse the underlying mechanism of residual stress evolution during cutting sequences. The results show that accumulated stress/strain induced by previous cuts lead to a more curled chip morphology, a slight decrease in cutting force and a slight increase in feed force in the subsequent cut. An increased magnitude and depth of compressive residual stresses in the finished workpiece are generated owing to the influence of previous cuts, and this is more obvious when the previous cut is implemented at a larger uncut chip thickness, using a more negative rake angle or a larger edge radius tool. The residual stress level might be controlled by optimizing the previous cuts to get the desired surface integrity.
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| 4. |
- Liu, Yang, et al.
(författare)
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Numerical and experimental investigation of tool geometry effect on residual stresses in orthogonal machining of Inconel 718
- 2021
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Ingår i: Simulation Modelling Practice and Theory. - : Elsevier BV. - 1569-190X. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- Residual stress has become more important than ever with the increasing performance requirement of components especially for those applied in safety-critical areas. As the machining process is fundamentally correlated with the acquired component properties, it is essential to fully understand the formation mechanism of residual stresses in the cutting process and its influence on the performance of the component. This paper presents results based on numerical and experimental analysis on the effect of tool geometry on thermal-mechanical load and residual stresses in orthogonal machining Inconel718 alloy. The Coupled Eulerian-Lagrangian (CEL) method is used to simulate the effect of tool geometry on temperatures, forces, equivalent plastic strains, and residual stresses. The local normal/tangential stress is introduced to determine the degree of the tensile plastic deformation induced by the tool. It is observed that a negative rake angle and a sharp edge radius tool tend to generate more compressive stress on the machined surface than the ones generated with positive rake angle tools and/or lager edge radius. Besides, an increase in flank wear produces less magnitude of compressive stress in subsurface due to a decreased local normal stress caused by increased flank contact length.
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| 5. |
- Liu, Yang, et al.
(författare)
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Numerical contribution to segmented chip effect on residual stress distribution in orthogonal cutting of Inconel718
- 2020
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Ingår i: International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 109, s. 993-1005
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Tidskriftsartikel (refereegranskat)abstract
- Segmented chip morphology has a significant influence on distribution of residual stress and surface topography on machined surface in machining difficult-to-cut materials. In this paper, Coupled Eulerian and Lagrangian (CEL) model is employed to investigate the effect of segmented chip on surface integrity (residual stress distribution and surface topography) in orthogonal machining of Inconel718 with uncoated carbide inserts. A mesh sensitivity study of chip morphology and residual stress distribution is performed by developing the following three different grid resolutions: coarse (mesh size 35 μm), medium (10 μm) and fine (5 μm). Comparing with the experimental results, it is clear that the numerical model presents reasonable results, including the chip morphology, temperature distribution, cutting forces, residual stress profile and surface fluctuation period. As for the generated surface integrity, a waved surface and cyclic residual stress distribution are found with the segmented chip due to the periodical mechanical and thermal loadings acting on the machined surface. Furthermore, the formation of single chip segment is investigated in-depth to explain the residual stress distribution generation.
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| 6. |
- Luo, Xiyu, et al.
(författare)
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Effects of local compositional heterogeneity in mixed halide perovskites on blue electroluminescence
- 2024
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Ingår i: Matter. - 2590-2393. ; 7:3, s. 1054-1070
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Tidskriftsartikel (refereegranskat)abstract
- Compositional heterogeneity is commonly observed in mixed bromide/iodide perovskite photoabsorbers, typically with minimal effects on charge carrier recombination and photovoltaic performance. Consistently, it has so far received very limited attention in bromide/chloride-mixed perovskites, which hold particular significance for blue light-emitting diodes. Here, we uncover that even a minor degree of localized halide heterogeneity leads to severe non-radiative losses in mixed bromide/chloride blue perovskite emitters, presenting a stark contrast to general observations in photovoltaics. We not only provide a visualization of the heterogeneity landscape spanning from micro-to sub-microscale but also identify that this issue mainly arises from the initially formed chloride-rich clusters during perovskite nucleation. Our work sheds light on a long-term neglected factor impeding the advancement of blue light-emitting diodes using mixed halide perovskites and provides a practical strategy to mitigate this issue.
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| 7. |
- Lv, Hao, et al.
(författare)
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Synthesis and Crystal-Phase Engineering of Mesoporous Palladium-Boron Alloy Nanoparticles
- 2020
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Ingår i: ACS central science. - : American Chemical Society (ACS). - 2374-7943 .- 2374-7951. ; 6:12, s. 2347-2353
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Tidskriftsartikel (refereegranskat)abstract
- Rational design and synthesis of noble metal nanomaterials with desired crystal phases (atomic level) and controllable structures/morphologies (mesoscopic level) are paramount for modulating their physiochemical properties. However, it is challenging to simultaneously explore atomic crystal-phase structures and ordered mesoscopic morphologies. Here, we report a simple synergistic templating strategy for the preparation of palladium-boron (Pd-B) nanoparticles with precisely controllable crystal-phases and highly ordered mesostructures. The engineering of crystal-phase structures at atomic levels is achieved by interstitially inserting metallic B atoms into face-centered cubic mesoporous Pd (fcc-mesoPd) confined in a mesoporous silica template. With the gradual insertion of B atoms, fcc-mesoPd is transformed into fcc-mesoPd(5)B, hcp-mesoPd(2)B with randomly distributed B atoms (hcp-mesoPd(2)B-r), and hcp-mesoPd(2)B with an atomically ordered B sequence (hcp-mesoPd(2)B-o) while preserving well-defined mesostructures. This synergistic templating strategy can be extended to engineer crystal-phase structures with various mesostructures/morphologies, including nanoparticles, nanobundles, and nanorods. Moreover, we investigate the crystal-phase-dependent catalytic performance toward the reduction reaction of p-nitrophenol and find that hcp-mesoPd(2)B-o displays much better catalytic activity. This work thus paves a new way for the synthesis of hcp-Pd2B nanomaterials with mesoscopically ordered structure/morphology and offers new insights of fcc-to-hcp evolution mechanisms which could be applied on other noble metal-based nanomaterials for various targeted applications.
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| 8. |
- Peng, Dongdong, et al.
(författare)
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Robust Particle Filter Based on Huber Function for Underwater Terrain Aided Navigation
- 2019
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Ingår i: IET radar, sonar & navigation. - : Institution of Engineering and Technology (IET). - 1751-8784 .- 1751-8792.
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Tidskriftsartikel (refereegranskat)abstract
- Terrain aided navigation is a promising technique to determine the location of underwater vehicle by matching terrain measurement against a known map. The particle filter is a natural choice for terrain aided navigation because of its ability to handle nonlinear, multimodal problems. However, the terrain measurements are vulnerable to outliers, which will cause the particle filter to degrade or even diverge. Modification of the Gaussian likelihood function by using robust cost functions is a way to reduce the effect of outliers on an estimate. We propose to use the Huber function to modify the measurement model used to set importance weights in a particle filter. We verify our method in simulations of multi-beam sonar in a real underwater digital map. The results demonstrate that the proposed method is more robust to outliers than the standard particle filter.
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| 9. |
- Weng, Jian, et al.
(författare)
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A comprehensive study on cutting mechanisms and surface integrity of AISI 304 when turning a curved surface
- 2021
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Ingår i: Materials and Manufacturing Processes. - : Informa UK Limited. - 1042-6914 .- 1532-2475. ; 36:11, s. 1285-1298
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Tidskriftsartikel (refereegranskat)abstract
- Most of the studies on cutting mechanisms and surface integrity in turning are investigated with a straight tool path (longitudinal/end face turning) while few contributions have been done in curved surface turning. This work explores the evolutions of cutting force, chip morphology and surface integrity when turning a curved surface, using fillet surface machining of AISI 304 stainless steel. The varying cutting conditions caused by the presented turning are revealed by detailed geometric analysis and employed as indicators for further discussions on cutting force, chip morphology, and machined surface integrity (including surface roughness, microhardness, microstructure, and residual stress). Apart from the difference of cutting force components in tangential, radial, and cutting speed directions along the fillet surface, wider and thinner chips are obtained from end face turning. The measured microhardness, microstructural alternation, and stress condition results comprehensively illustrate a reduction of severe plastic deformation from the outer face to the end face.
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| 10. |
- Weng, Jian, et al.
(författare)
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An analytical method for continuously predicting mechanics and residual stress in fillet surface turning
- 2021
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Ingår i: Journal of Manufacturing Processes. - : Elsevier BV. - 1526-6125. ; 68, s. 1860-1879
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Tidskriftsartikel (refereegranskat)abstract
- A novel and effective approach for determining mechanics and residual stress when turning a component with curved surfaces is presented in this paper. This predictive approach is based on a three-dimensional analytical model to study the distributed mechanics and residual stress caused by vary cutting condition during the machining process. The variation of uncut chip area in this process can be divided into several stages based on different tool-workpiece contact and the discretization of cutting edge is conducted at an arbitrary tool position. The chip flow direction is calculated through the equilibrium of the incremental interaction forces. The cutting force can be determined by integrating the force components along the cutting edge, with each incremental force component obtained based on a fully analytical model. Distributed heat source intensity is considered to model the temperature rise at an arbitrary point in workpiece. The residual stress in curved surface machining is obtained considering the loading-unloading-relaxation procedure at the engagement of cutting edge and machined surface. Finally, Finite Element (FE) modeling and experiments are performed to validate the correctness and robustness of the analytical model proposed in this paper. The results of predicted chip flow direction, cutting force, temperature, and residual stress show good agreement with the simulated and measured results.
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