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- Liu, Lihui, et al.
(författare)
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Dynamic toxicity landscape of immunotherapy for solid tumors across treatment lines
- 2023
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Ingår i: Journal of the National Cancer Center. - : Elsevier. - 2667-0054. ; 3:3, s. 186-196
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Immune checkpoint inhibitors (ICIs) targeting programmed cell death-1/ligand-1 (PD-1/PD-L1), cytotoxic T lymphocyte antigen-4 (CTLA-4), and lymphocyte-activation gene-3 (LAG-3) have been widely studied and applied throughout the course of cancer treatment. This study aimed to provide a comprehensive profile of ICI-associated toxicity and elucidate the toxicity patterns of ICIs across different treatment lines. Methods: In total, 155 cohorts comprising 24 539 eligible patients were included in the safety analysis. Trial name, registration number, cancer type, trial phase, clinical setting, trial design, regimen, dosing schedule, age, sex and ethnicity distributions, number of patients, number of treatment-related adverse events (trAEs), and number of treatment-related death were extracted. We defined a timeline from the neoadjuvant setting to the third-line setting. We also introduced a synthesizing principle for adverse event rates (SPAER) of immunotherapy to ensure the comparability and reliability across different treatment lines. The study protocol was registered and approved by the PROSPERO protocol review committee (CRD42021242368). Results: After excluding the neoadjuvant setting group, we observed a distinct reduction in the incidence of treatment-related adverse events (trAEs) with an advancement of the line of ICI treatment. The incidence of trAEs was negatively correlated with the line of treatment, irrespective of whether monotherapy or dual-ICI combination therapy was administered. Sensitivity analyses also confirmed the coincident negative correlations. Conclusion: In summary, using a timeline-based concept centered around treatment lines, we revealed the dynamic landscape of ICI-associated toxicity and found that patients treated with ICIs during later lines of therapy may have a lower risk of trAEs.
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| 3. |
- Chang, Jianghao, et al.
(författare)
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Diffusion Law of Whole-Space Transient Electromagnetic Field Generated by the Underground Magnetic Source and Its Application
- 2019
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Ingår i: IEEE Access. - : IEEE. - 2169-3536. ; 7, s. 63415-63425
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Tidskriftsartikel (refereegranskat)abstract
- Mine water inrush stays as one of the major disasters in coalmine production and construction. As one of the principal methods for detecting hidden water-rich areas in coal mines, underground transient electromagnetic method (TEM) adopts the small loop of a magnetic source which generates a kind of whole-space transient electromagnetic field. To study the diffusion of whole-space transient electromagnetic field, a 3-D finite-difference time-domain (FDTD) is employed in simulating the diffusion pattern of whole-space transient electromagnetic field created by the magnetic source in any direction and the whole-space transient electromagnetic response of the 3-D low-resistance body. The simulation results indicate that the diffusion of whole-space transient electromagnetic field is different from ground half-space and that it does not conform to the "smoke ring effect'' of half-space transient electromagnetic field, for the radius of the electric field's contour ring in whole space keeps expanding without moving upward or downward. The low-resistance body can significantly affect the diffusion of transient electromagnetic field. When the excitation direction is consistent with the bearing of the low-resistance body, the coupling between the transient electromagnetic field and the low-resistance body is optimal, and the abnormal response is most obvious. The bearing of the low-resistance body can be distinguished by comparing the response information of different excitation directions. Based on the results above, multi-directional sector detection technology is adapted to detect the water-rich areas, which can not only detect the target ahead of the roadway but also distinguish the bearing of the target. Both numerical simulation and practical application in underground indicate that the mining TEM can accurately reflect the location of water-rich areas.
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