| 1. |
- Rani, Palak, et al.
(författare)
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Recent patent-based review on the role of three-dimensional printing technology in pharmaceutical and biomedical applications
- 2023
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Ingår i: Pharmaceutical Patent Analyst. - 2046-8954. ; 12:4, s. 159-175
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Forskningsöversikt (refereegranskat)abstract
- Three-dimensional printing (3DP) is emerging as an innovative manufacturing technology for biomedical and pharmaceutical applications, since the US FDA approval of Spritam as a 3D-printed drug. In the present review, we have highlighted the potential benefits of 3DP technology in healthcare, such as the ability to create patient-specific medical devices and implants, as well as the possibility of on-demand production of drugs and personalized dosage forms. We have further discussed future research to optimize 3DP processes and materials for pharmaceutical and biomedical applications. Cohesively, we have put forward the current state of active patents and applications related to 3DP technology in the healthcare and pharmaceutical industries including hearing aids, prostheses, medical devices and drug-delivery systems.
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| 2. |
- Yadav, Vikas, et al.
(författare)
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Implications of antibiotics and antimicrobial resistance development during COVID-19 : questing genomic surveillance for a balancing act
- 2023
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Ingår i: Genomic Surveillance and Pandemic Preparedness. - 9780443187698 - 9780443187681 ; , s. 375-395
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Bokkapitel (refereegranskat)abstract
- The COVID-19 pandemic has jolted the health system globally and a paucity of specific drugs and/or vaccine hesitancy led clinicians to indiscriminately use antibiotics. Furthermore, during the early waves of the COVID-19 pandemic, several studies showcased the anti-SARS-CoV-2 efficacy of few antibiotics which further catapulted the idea of using them after emergency approval by the Food and Drug Authority (FDA). This nonjudicial use of antibiotics has unfortunately led to the evolution of antimicrobial resistance (AMR) as a silent pandemic. In this chapter, we describe the previous and recent studies highlighting several antibiotics that are either predicted to target the SARS-CoV-2 virus and/or shown to have efficacy in managing patients with COVID-19. We also discussed the negative implication of antibiotics during COVID-19 and why proper genomic surveillance is required to mitigate the development of AMR in the present and future pandemics.
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| 3. |
- Jena, Manoj Kumar, et al.
(författare)
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Molecular complexity of mammary glands development : a review of lactogenic differentiation in epithelial cells
- 2023
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Ingår i: Artificial Cells, Nanomedicine and Biotechnology. - 2169-1401. ; 51:1, s. 491-508
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Tidskriftsartikel (refereegranskat)abstract
- The mammary gland is a dynamic organ with various physiological processes like cellular proliferation, differentiation, and apoptosis during the pregnancy-lactation-involution cycle. It is essential to understand the molecular changes during the lactogenic differentiation of mammary epithelial cells (MECs, the milk-synthesizing cells). The MECs are organized as luminal milk-secreting cells and basal myoepithelial cells (responsible for milk ejection by contraction) that form the alveoli. The branching morphogenesis and lactogenic differentiation of the MECs prepare the gland for lactation. This process is governed by many molecular mediators including hormones, growth factors, cytokines, miRNAs, regulatory proteins, etc. Interestingly, various signalling pathways guide lactation and understanding these molecular transitions from pregnancy to lactation will help researchers design further research. Manipulation of genes responsible for milk synthesis and secretion will promote augmentation of milk yield in dairy animals. Identifying protein signatures of lactation will help develop strategies for persistent lactation and shortening the dry period in farm animals. The present review article discusses in details the physiological and molecular changes occurring during lactogenic differentiation of MECs and the associated hormones, regulatory proteins, miRNAs, and signalling pathways. An in-depth knowledge of the molecular events will aid in developing engineered cellular models for studies related to mammary gland diseases of humans and animals.
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| 4. |
- Johri, Atul K., et al.
(författare)
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Fungal association and utilization of phosphate by plants : success, limitations, and future prospects
- 2015
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Ingår i: Frontiers in Microbiology. - : Frontiers Media SA. - 1664-302X. ; 6
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Forskningsöversikt (refereegranskat)abstract
- Phosphorus (P) is a major macronutrient for plant health and development. The available form of P is generally low in the rhizosphere even in fertile soils. A major proportion of applied phosphate (Pi) fertilizers in the soil become fixed into insoluble, unavailable forms, which restricts crop production throughout the world. Roots possess two distinct modes of P uptake from the soil, direct and indirect uptake. The direct uptake of P is facilitated by the plant's own Pi transporters while indirect uptake occurs via mycorrhizal symbiosis, where the host plant obtains P primarily from the fungal partner, while the fungus benefits from plant-derived reduced carbon. So far, only one Pi transporter has been characterized from the mycorrhizal fungus Glomus versiforme. As arbuscular mycorrhizal fungi cannot be cultured axenically, their Pi transporter network is difficult to exploite for large scale sustainable agriculture. Alternatively, the root-colonizing endophytic fungus Piriformospora indica can grow axenically and provides strong growth-promoting activity during its symbiosis with a broad spectrum of plants. P indica contains a high affinity Pi transporter (PiPT) involved in improving Pi nutrition levels in the host plant under P limiting conditions. As P indica can be manipulated genetically, it opens new vistas to be used in P deficient fields.
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| 5. |
- Mohapatra, Purusottam, et al.
(författare)
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WNT5A-induced activation of the protein kinase C substrate MARCKS is required for melanoma cell invasion
- 2020
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- WNT5A is a well-known mediator of melanoma cell invasion and metastasis via its ability to activate protein kinase C (PKC), which is monitored by phosphorylation of the endogenous PKC substrate myristoylated alanine-rich c-kinase substrate (MARCKS). However, a possible direct contribution of MARCKS in WNT5A-mediated melanoma cell invasion has not been investigated. Analyses of melanoma patient databases suggested that similar to WNT5A expression, MARCKS expression appears to be associated with increased metastasis. A relationship between the two is suggested by the findings that recombinant WNT5A (rWNT5A) induces both increased expression and phosphorylation of MARCKS, whereas WNT5A silencing does the opposite. Moreover, WNT5A-induced invasion of melanoma cells was blocked by siRNA targeting MARCKS, indicating a crucial role of MARCKS expression and/or its phosphorylation. Next, we employed a peptide inhibitor of MARCKS phosphorylation that did not affect MARCKS expression and found that it abolished WNT5A-induced melanoma cell invasion. Similarly, rWNT5A induced the accumulation of phosphorylated MARCKS in membrane protrusions at the leading edge of melanoma cells. Our results demonstrate that WNT5A-induced phosphorylation of MARCKS is not only an indicator of PKC activity but also a crucial regulator of the metastatic behavior of melanoma and therefore an attractive future antimetastatic target in melanoma patients.
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| 6. |
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| 7. |
- Peng, Shen, et al.
(författare)
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Chance-constrained games with mixture distributions
- 2021
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Ingår i: Mathematical Methods of Operations Research. - : Springer Nature. - 1432-2994 .- 1432-5217. ; 94:1, s. 71-97
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we consider an n-player non-cooperative game where the random payoff function of each player is defined by its expected value and her strategy set is defined by a joint chance constraint. The random constraint vectors are independent. We consider the case when the probability distribution of each random constraint vector belongs to a subset of elliptical distributions as well as the case when it is a finite mixture of the probability distributions from the subset. We propose a convex reformulation of the joint chance constraint of each player and derive the bounds for players’ confidence levels and the weights used in the mixture distributions. Under mild conditions on the players’ payoff functions, we show that there exists a Nash equilibrium of the game when the players’ confidence levels and the weights used in the mixture distributions are within the derived bounds. As an application of these games, we consider the competition between two investment firms on the same set of portfolios. We use a best response algorithm to compute the Nash equilibria of the randomly generated games of different sizes.
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| 8. |
- Proletov, Ian, et al.
(författare)
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Primary and secondary glomerulonephritides 1.
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29 Suppl 3:May, s. 186-200
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Tidskriftsartikel (refereegranskat)
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| 9. |
- Sharma, Shikha, et al.
(författare)
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Emerging challenges in antimicrobial resistance : implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability
- 2024
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Ingår i: Frontiers in Microbiology. - 1664-302X. ; 15
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Forskningsöversikt (refereegranskat)abstract
- Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic microbes which is a growing public health challenge at the global level. Higher resistance causes severe infections, high complications, longer stays at hospitals and even increased mortality rates. Antimicrobial resistance (AMR) has a significant impact on national economies and their health systems, as it affects the productivity of patients or caregivers due to prolonged hospital stays with high economic costs. The main factor of AMR includes improper and excessive use of antimicrobials; lack of access to clean water, sanitation, and hygiene for humans and animals; poor infection prevention and control measures in hospitals; poor access to medicines and vaccines; lack of awareness and knowledge; and irregularities with legislation. AMR represents a global public health problem, for which epidemiological surveillance systems have been established, aiming to promote collaborations directed at the well-being of human and animal health and the balance of the ecosystem. MDR bacteria such as E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., and Klebsiella pneumonia can even cause death. These microorganisms use a variety of antibiotic resistance mechanisms, such as the development of drug-deactivating targets, alterations in antibiotic targets, or a decrease in intracellular antibiotic concentration, to render themselves resistant to numerous antibiotics. In context, the United Nations issued the Sustainable Development Goals (SDGs) in 2015 to serve as a worldwide blueprint for a better, more equal, and more sustainable existence on our planet. The SDGs place antimicrobial resistance (AMR) in the context of global public health and socioeconomic issues; also, the continued growth of AMR may hinder the achievement of numerous SDGs. In this review, we discuss the role of environmental pollution in the rise of AMR, different mechanisms underlying the antibiotic resistance, the threats posed by pathogenic microbes, novel antibiotics, strategies such as One Health to combat AMR, and the impact of resistance on sustainability and sustainable development goals.
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| 10. |
- Singh, Tejveer, et al.
(författare)
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The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers : Recent Trends and Future Perspectives
- 2024
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Ingår i: Cancers. - 2072-6694. ; 16:9
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Forskningsöversikt (refereegranskat)abstract
- In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment.
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