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- Schriber, Jeffrey R., et al.
(författare)
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Hispanics Have the Lowest Stem Cell Transplant Utilization Rate for Autologous Hematopoietic Cell Transplantation for Multiple Myeloma in the United States : A CIBMTR Report
- 2017
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Ingår i: Cancer. - : John Wiley & Sons. - 0008-543X .- 1097-0142. ; 123:16, s. 3141-3149
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Race/ethnicity remains an important barrier in clinical care. The authors investigated differences in the receipt of autologous hematopoietic cell transplantation (AHCT) among patients with multiple myeloma (MM) and outcomes based on race/ethnicity in the United States. METHODS: The Center for International Blood and Marrow Transplant Research database was used to identify 28,450 patients who underwent AHCT for MM from 2008 through 2014. By using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results 18 registries, the incidence of MM was calculated, and a stem cell transplantation utilization rate (STUR) was derived. Post-AHCT outcomes were analyzed among patients ages 18 to 75 years who underwent melphalan-conditioned peripheral cell grafts (N = 24,102). RESULTS: The STUR increased across all groups from 2008 to 2014. The increase was substantially lower among Hispanics (range, 8.6%-16.9%) and non-Hispanic blacks (range, 12.2%-20.5%) compared with non-Hispanic whites (range, 22.6%-37.8%). There were 18,046 non-Hispanic whites, 4123 non-Hispanic blacks, and 1933 Hispanic patients. The Hispanic group was younger (P <.001). Fewer patients older than 60 years underwent transplantation among Hispanics (39%) and nonHispanic blacks (42%) compared with non-Hispanic whites (56%). A Karnofsky score <90% and a hematopoietic cell transplantation comorbidity index score >3 were more common in non-Hispanic blacks compared with Hispanic and non-Hispanic whites (P <.001). More Hispanics (57%) versus non-Hispanic blacks (54%) and non-Hispanic whites (52%; P <.001) had stage III disease. More Hispanics (48%) versus non-Hispanic blacks (45%) and non-Hispanic whites (44%) had a very good partial response or better before transplantation (P =.005). Race/ethnicity did not impact post-AHCT outcomes. CONCLUSIONS: Although the STUR increased, it remained low and was significantly lower among Hispanics followed by non-Hispanic blacks compared with non-Hispanic whites. Race/ethnicity did not impact transplantation outcomes. Efforts to increase the rates of transplantation for eligible patients who have MM, with an emphasis on groups that underuse transplantation, are warranted. (C) 2017 American Cancer Society.
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- Storm, Louise K., et al.
(författare)
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Ten essential features of European dual career development environments : A multiple case study
- 2021
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Ingår i: Psychology of Sport And Exercise. - Amsterdam : Elsevier Ltd. - 1469-0292 .- 1878-5476. ; 54
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Dual career development environments (DCDEs) support athletes' effort in combining their competitive sporting careers with education or work. The characteristics of the environments may differ across cultures. The aim was to identify essential features of DCDEs based on a cross-case analysis of seven European DCDEs in Belgium, Denmark, Finland, Slovenia, Spain, Sweden, and the United Kingdom within the Erasmus+ Sport project “Ecology of Dual Career”. Design: The study was designed as a multiple case study and based on two holistic ecological working models (Henriksen et al., 2020). The cross-case analysis included series of focus group discussions, in which two-three researchers from each partner country and four dual career (DC) support providers compared the findings across seven national cases with a primary focus on similarities rather than differences. Results: A list of ten essential features of the DCDEs, structured into two overarching themes. (1) Holistic structure with five subthemes: Dedicated DC support team, Integration of efforts across the whole environment, A clear understanding of DC issues and support from across the environment, Role models and mentorship, and Access to expert support. (2) Shared DC philosophy also had five subthemes: A whole-person approach, An empowerment approach, Flexible DC solutions, Care of DC athlete's mental health and wellbeing, and An open and proactive approach to the development of the environment. Conclusion: The features are introduced in the manner of discussions, thus providing detailed information about the DCDEs without losing (too much) contextual information. These features can help researcher-practitioners to understand DCDEs and guide their optimization. © 2021 Elsevier Ltd
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