| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 3. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 4. |
- Jia, Xue, et al.
(författare)
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CsPb(IxBr1-x)(3) solar cells
- 2019
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Ingår i: Science Bulletin. - : ELSEVIER. - 2095-9273. ; 64:20, s. 1532-1539
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Tidskriftsartikel (refereegranskat)abstract
- Owing to its nice performance, low cost, and simple solution-processing, organic-inorganic hybrid perovskite solar cell (PSC) becomes a promising candidate for next-generation high-efficiency solar cells. The power conversion efficiency (PCE) has boosted from 3.8% to 25.2% over the past ten years. Despite the rapid progress in PCE, the device stability is a key issue that impedes the commercialization of PSCs. Recently, all-inorganic cesium lead halide perovskites have attracted much attention due to their better stability compared with their organic-inorganic counterpart. In this progress report, we summarize the properties of CsPb(IxBr1-x)(3) and their applications in solar cells. The current challenges and corresponding solutions are discussed. Finally, we share our perspectives on CsPb(IxBr1-x)(3) solar cells and outline possible directions to further improve the device performance. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
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| 5. |
- Lensink, Marc F., et al.
(författare)
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15-CAPRI experiment
- 2023
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Ingår i: Proteins. - : WILEY. - 0887-3585 .- 1097-0134.
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Tidskriftsartikel (refereegranskat)abstract
- We present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody-antigen complexes, and 7 large assemblies. On average similar to 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High-quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2-Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2-Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.
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| 6. |
- Peng, Liming, et al.
(författare)
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Phase-modulated mechanical and thermoelectric properties of Ag2S1-x Tex ductile semiconductors
- 2022
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Ingår i: Journal of Materiomics. - : Elsevier. - 2352-8478 .- 2352-8486. ; 8:3, s. 656-661
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Tidskriftsartikel (refereegranskat)abstract
- By virtue of the excellent plasticity and tunable transport properties, Ag2S-based materials demonstrate an intriguing prospect for flexible or hetero-shaped thermoelectric applications. Among them, Ag(2)S1-xTex exhibits rich and interesting variations in crystal structure, mechanical and thermoelectric transport properties. However, Te alloying obviously introduces extremely large order-disorder distributions of cations and anions, leading to quite complicated crystal structures and thermoelectric properties. Detailed composition-structure-performance correlation of Ag2S1-xTex still remains to be established. In this work, we designed and prepared a series of Ag2S1-xTex (x = 0-0.3) materials with low Te content. We discovered that the monoclinic-to-cubic phase transition occurs around x = 0.16 at room temperature. Te alloying plays a similar role as heating in facilitating this monoclinic-to-cubic phase transition, which is analyzed based on the thermodynamic principles. Compared with the monoclinic counterparts, the cubic-structured phases are more ductile and softer in mechanical properties. In addition, the cubic phases show a degenerately semiconducting behavior with higher thermoelectric performance. A maximum zT = 0.8 at 600 K and bending strain larger than 20% at room temperature were obtained in Ag2S0.7Te0.3. This work provides a useful guidance for designing Ag2S-based alloys with enhanced plasticity and high thermoelectric performance.
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| 7. |
- Qiu, Hailong, et al.
(författare)
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Intense ultraviolet upconversion emission from water-dispersed colloidal YF3:Yb3+/Tm3+ rhombic nanodisks
- 2014
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 6:2, s. 753-757
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Tidskriftsartikel (refereegranskat)abstract
- Intense ultraviolet upconversion emission has been observed in water-dispersed uniform rhombic nanodisks (side length of similar to 14 nm and thickness of similar to 2.5 nm) of YF3 co-doped with Yb3+ sensitizer and Tm3+ activator ions, when excited at similar to 980 nm.
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| 8. |
- Tong, Yang, et al.
(författare)
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Progress of the key materials for organic solar cells
- 2020
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Ingår i: Science in China Series B. - Beijing, China : SCIENCE PRESS. - 1674-7291 .- 1869-1870. ; 63:6, s. 758-765
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Forskningsöversikt (refereegranskat)abstract
- Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight, flexibility and roll-to-roll fabrication. Nowadays, 18% power conversion efficiency has been achieved in the state-of-the-art organic solar cells. The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies, and the deep understanding on film morphology, molecular packing and device physics. Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance. The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors. In this review, we focus on those star materials and milestone work, and introduce the molecular structure evolution of key materials. These key materials include homopolymer donors, D-A copolymer donors, A-D-A small molecular donors, fullerene acceptors and nonfullerene acceptors. At last, we outlook the challenges and very important directions in key materials development.
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| 9. |
- Yang, Qingyu, et al.
(författare)
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Flexible thermoelectrics based on ductile semiconductors
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 377, s. 854-858
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Tidskriftsartikel (refereegranskat)abstract
- Flexible thermoelectrics provide a different solution for developing portable and sustainable flexiblepower supplies. The discovery of silver sulfide–based ductile semiconductors has driven a shift in thepotential for flexible thermoelectrics, but the lack of good p-type ductile thermoelectric materials hasrestricted the reality of fabricating conventional cross-plane p-shaped flexible devices. We report aseries of high-performance p-type ductile thermoelectric materials based on the composition-performance phase diagram in AgCu(Se,S,Te) pseudoternary solid solutions, with high figure-of-meritvalues (0.45 at 300 kelvin and 0.68 at 340 kelvin) compared with other flexible thermoelectricmaterials. We further demonstrate thin and flexible p-shaped devices with a maximum normalizedpower density that reaches 30 mW cm−2 K−2. This output is promising for the use of flexiblethermoelectrics in wearable electronics.
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| 10. |
- Zhang, Lixiu, et al.
(författare)
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Advances in the Application of Perovskite Materials
- 2023
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Ingår i: NANO-MICRO LETTERS. - : SHANGHAI JIAO TONG UNIV PRESS. - 2311-6706. ; 15:1
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Forskningsöversikt (refereegranskat)abstract
- Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices (solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices (artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices.
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