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- Yu, Yingyue, et al.
(författare)
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Cutting Power, Temperature, and Surface Roughness: A Multiple Target Assessment of Beech during Diamond Milling
- 2023
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Ingår i: Forests. - : MDPI. - 1999-4907. ; 14:6
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Tidskriftsartikel (refereegranskat)abstract
- Beech wood is a material commonly used for furniture, and cutting performance is the key to improving product quality and enterprise benefits. In this work, beech milling experiments using diamond cutters were carried out, and the changes in cutting power, temperature, and surface roughness were examined using the factor analysis method. The main results of this work are listed as follows: Firstly, a higher cutting speed and depth led to higher cutting power, temperature, and surface roughness. Meanwhile, cutting power and surface roughness were negatively related to the rake angle; however, cutting temperature first increased and then decreased with the increase in rake angle. Furthermore, cutting depth had greatest impact on the cutting power and surface roughness, followed by rake angle and cutting speed. Cutting speed had the greatest contribution to the cutting temperature, followed by cutting depth and rake angle. Only the cutting depth had a significant contribution to both cutting power, temperature, and surface roughness. Finally, optimal cutting parameters were determined to be a rake angle of 15°, cutting speed of 54 m/s, and depth of 0.5 mm. These values best meet the multiple objectives of lower cutting power, temperature, and surface roughness, which relate to superior product quality and enterprise benefits.
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| 2. |
- Zhao, Xiaoyu, et al.
(författare)
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Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls
- 2024
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Ingår i: Cancer. - : John Wiley & Sons. - 0008-543X .- 1097-0142. ; 130:6, s. 913-926
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although the associations between genetic variations and lung cancer risk have been explored, the epigenetic consequences of DNA methylation in lung cancer development are largely unknown. Here, the genetically predicted DNA methylation markers associated with non–small cell lung cancer (NSCLC) risk by a two-stage case-control design were investigated.Methods: The genetic prediction models for methylation levels based on genetic and methylation data of 1595 subjects from the Framingham Heart Study were established. The prediction models were applied to a fixed-effect meta-analysis of screening data sets with 27,120 NSCLC cases and 27,355 controls to identify the methylation markers, which were then replicated in independent data sets with 7844 lung cancer cases and 421,224 controls. Also performed was a multi-omics functional annotation for the identified CpGs by integrating genomics, epigenomics, and transcriptomics and investigation of the potential regulation pathways.Results: Of the 29,894 CpG sites passing the quality control, 39 CpGs associated with NSCLC risk (Bonferroni-corrected p ≤ 1.67 × 10−6) were originally identified. Of these, 16 CpGs remained significant in the validation stage (Bonferroni-corrected p ≤ 1.28 × 10−3), including four novel CpGs. Multi-omics functional annotation showed nine of 16 CpGs were potentially functional biomarkers for NSCLC risk. Thirty-five genes within a 1-Mb window of 12 CpGs that might be involved in regulatory pathways of NSCLC risk were identified.Conclusions: Sixteen promising DNA methylation markers associated with NSCLC were identified. Changes of the methylation level at these CpGs might influence the development of NSCLC by regulating the expression of genes nearby.Plain Language Summary: The epigenetic consequences of DNA methylation in lung cancer development are still largely unknown. This study used summary data of large-scale genome-wide association studies to investigate the associations between genetically predicted levels of methylation biomarkers and non–small cell lung cancer risk at the first time. This study looked at how well larotrectinib worked in adult patients with sarcomas caused by TRK fusion proteins. These findings will provide a unique insight into the epigenetic susceptibility mechanisms of lung cancer.
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