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Sökning: WFRF:(Yang Sijun)

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1.
  • Li, Bo, et al. (författare)
  • Wind tunnel test study on influence of open/close operation on aerodynamic noise characteristics of high-speed pantographs
  • 2024
  • Ingår i: Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology). - 1672-7207. ; 55:5, s. 1846-1854
  • Tidskriftsartikel (refereegranskat)abstract
    • Wind tunnel tests of aerodynamic noise at wind speeds from 160 km/h to 324 km/h were carried out for high speed pantograph developed by Beijing CRRC CED Co. Ltd. The effects of wind speed and open/close operation status on pantograph aerodynamic noise characteristics were analyzed, and the pantograph aerodynamic noise at higher speed was predicted. The results show that the aerodynamic noise of the pantograph and its propagation characteristics are closely related to the wind speed and operating status. The panhead and nearby areas are prone to single-tone noise due to the influence of shedding vortices. The total sound pressure energy of the far-field noise increases with the power of 5.6 − 6.0 of wind speed. The total sound pressure levels of the pantograph far-field noise in the open/closed state are predicted to be about 106.8 dB and 106.6 dB respectively at the wind speed of 400 km/h by data fitting.
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2.
  • Peiris, Heshan, et al. (författare)
  • A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes
  • 2016
  • Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 12:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial dysfunction and reduced insulin secretion are also observed in β-cells of humans with the most common human genetic disorder, Down syndrome (DS, Trisomy 21). To identify regions of chromosome 21 that may be associated with perturbed glucose homeostasis we profiled the glycaemic status of different DS mouse models. The Ts65Dn and Dp16 DS mouse lines were hyperglycemic, while Tc1 and Ts1Rhr mice were not, providing us with a region of chromosome 21 containing genes that cause hyperglycemia. We then examined whether any of these genes were upregulated in a set of ~5,000 gene expression changes we had identified in a large gene expression analysis of human T2D β-cells. This approach produced a single gene, RCAN1, as a candidate gene linking hyperglycemia and functional changes in T2D β-cells. Further investigations demonstrated that RCAN1 methylation is reduced in human T2D islets at multiple sites, correlating with increased expression. RCAN1 protein expression was also increased in db/db mouse islets and in human and mouse islets exposed to high glucose. Mice overexpressing RCAN1 had reduced in vivo glucose-stimulated insulin secretion and their β-cells displayed mitochondrial dysfunction including hyperpolarised membrane potential, reduced oxidative phosphorylation and low ATP production. This lack of β-cell ATP had functional consequences by negatively affecting both glucose-stimulated membrane depolarisation and ATP-dependent insulin granule exocytosis. Thus, from amongst the myriad of gene expression changes occurring in T2D β-cells where we had little knowledge of which changes cause β-cell dysfunction, we applied a trisomy 21 screening approach which linked RCAN1 to β-cell mitochondrial dysfunction in T2D.
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