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Träfflista för sökning "WFRF:(Yao Ruifeng) "

Sökning: WFRF:(Yao Ruifeng)

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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Zhao, Shijing, et al. (författare)
  • Elucidating the reaction pathway of crystalline multi-metal borides for highly efficient oxygen-evolving electrocatalysts
  • 2022
  • Ingår i: Journal of Materials Chemistry A. - : ROYAL SOC CHEMISTRY. - 2050-7488 .- 2050-7496. ; 10:3, s. 1569-1578
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding the fundamental principle of catalytic performance and the mechanism of multimetal-based electrocatalysts is essential for the rational design of advanced renewable energy systems. Here, highly crystalline MMMoB4 (M = Fe, Co) compounds with controllable compositions of multiple active metal atoms and polyacene-type boron networks were synthesized delicately by a one-step high-pressure technique to explore electrocatalytic selectivity and activity. CoFeMoB4 and Co2MoB4 are revealed to be highly active and durable oxygen evolution reaction (OER) electrocatalysts under alkaline conditions. The mutually promotive activation of metals with amorphous clusters and ultra-small grains on the surface are responsible for the enhanced activity of CoFeMoB4. More specifically, Co and Fe coupling in CoFeMoB4 facilitates surface reconstruction into active Co hydroxide and Fe oxyhydroxide, in contrast to Co oxyhydroxide in Co2MoB4 and Fe oxides in Fe2MoB4. Dissolving Mo may provide potential space for adsorbing hydroxyl, and the optimized electronic structure with boron is mainly responsible for the long-term durability. In contrast, Mo atoms are responsible for hydrogen evolution reaction (HER) properties, and the optimized d-band center and density of states at the Fermi level make Co2MoB4 a superior HER catalyst. Our findings provide insight into distinguishing the catalytic pathway of multi-metal borides with improved OER activity and different roles of Mo and Co/Fe in the HER and OER.
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3.
  • Xu, An, et al. (författare)
  • Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
  • 2023
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • N6-methyladenosine (m6A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role in modulating both biological and pathological processes. However, it is unknown whether mutant p53 neomorphic oncogenic functions exploit dysregulation of m6A epitranscriptomic networks. Here, we investigate Li-Fraumeni syndrome (LFS)-associated neoplastic transformation driven by mutant p53 in iPSC-derived astrocytes, the cell-of-origin of gliomas. We find that mutant p53 but not wild-type (WT) p53 physically interacts with SVIL to recruit the H3K4me3 methyltransferase MLL1 to activate the expression of m6A reader YTHDF2, culminating in an oncogenic phenotype. Aberrant YTHDF2 upregulation markedly hampers expression of multiple m6A-marked tumor-suppressing transcripts, including CDKN2B and SPOCK2, and induces oncogenic reprogramming. Mutant p53 neoplastic behaviors are significantly impaired by genetic depletion of YTHDF2 or by pharmacological inhibition using MLL1 complex inhibitors. Our study reveals how mutant p53 hijacks epigenetic and epitranscriptomic machinery to initiate gliomagenesis and suggests potential treatment strategies for LFS gliomas.
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  • Resultat 1-3 av 3

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