| 1. |
- Aoki, Sayaka, et al.
(författare)
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Development of a new screening tool for neuromotor development in children aged two - the neuromotor 5min exam 2-year-old version (N5E2).
- 2018
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Ingår i: Brain & development. - : Elsevier BV. - 1872-7131 .- 0387-7604. ; 40:6, s. 445-451
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Tidskriftsartikel (refereegranskat)abstract
- As a new screening tool for neuromotor development in children aged two, we developed the Neuromotor 5min Exam 2-year-old version (N5E2), which can be easily administered by pediatricians or primary care physicians. In this study, as an initial attempt to examine the utility of the N5E2, the inter-rater reliability on scoring for the individual items in this scale was assessed.The participants of the study were 29 children (aged 1-5years, mean age=2.79) diagnosed with a variety of neuromotor/developmental disorders/high-risk conditions. Inter-rater reliability was examined on the following 11 items in the N5E2: (1) Retrieving a rolling ball, (2) Gait, (3) Toe-walking, (4) Asymmetries of posture and/or movement, (5) Age at unsupported walking, (6) Speaking in two-word understandable sentences, (7) Hypotonus, (8) Hypertonus, (9) Eye movement, (10) Vision problem, (11) Hearing problem. The items were administered to children by two pediatricians with different expertise and clinical experience, separately.The results showed that among the eleven items in the N5E2 examined, a high level of agreement (κ≥0.60) was found on 4 items, and a moderate level of agreement (0.40≤κ<0.60) was found on 5 items. The level of agreement somewhat improved after the dichotomization of the score; using this format, a high level of rater agreement (κ≥0.60) was found on 6 out of 11 items. The analyses also revealed high inter-rater reliability on the sum score of the 11 items (r=0.84).The results suggest the possibility that this brief screening tool could be feasible in settings where clinicians' experience varies, based on its inter-rater reliability on individual items between the clinicians with different expertise and amount of clinical experiences.
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| 2. |
- Dinkler, Lisa, et al.
(författare)
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Development of a parent-reported screening tool for avoidant/restrictive food intake disorder (ARFID): Initial validation and prevalence in 4-7-year-old Japanese children
- 2022
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Ingår i: Appetite. - : Elsevier BV. - 0195-6663. ; 168
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Tidskriftsartikel (refereegranskat)abstract
- The prevalence of avoidant/restrictive food intake disorder (ARFID) in the general child population is still largely unknown and validated screening instruments are lacking. The aims of this study were (1) to investigate the prevalence of children screening positive for ARFID in a Japanese birth cohort using a newly developed parent-reported screening tool, (2) to estimate the prevalence of children with ARFID experiencing physical versus psychosocial consequences of their eating pattern, and (3) to provide preliminary evidence for the validity of the new screening tool. Data were collected from 3728 4-7-year-old children born between 2011 and 2014 in Kochi prefecture, Japan (response rate was 56.5%); a sub-sample of the Japan Environment and Children's Study (JECS). Parents completed a questionnaire including the ARFID screener and several other measures to assess convergent validity. The point prevalence of children screening positive for ARFID was 1.3%; half of them met criteria for ARFID based on psychosocial impairment alone, while the other half met diagnostic criteria relating to physical impairment (and additional psychosocial impairment in many cases). Sensory sensitivity to food characteristics (63%) and/or lack of interest in eating (51%) were the most prevalent drivers of food avoidance. Children screening positive for ARFID were lighter in weight and shorter in height, they showed more problem behaviors related to mealtimes and nutritional intake, and they were more often selective eaters and more responsive to satiety, which together provides preliminary support for the validity of the new screening tool. This is the largest screening study to date of ARFID in children up to 7 years. Future studies should examine the diagnostic validity of the new ARFID screener using clinically ascertained cases. Further research on ARFID prevalence in the general population is needed.
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| 3. |
- Hatakenaka, Yuhei, 1959, et al.
(författare)
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Infant Motor Delay and Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations in Japan.
- 2016
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Ingår i: Pediatric neurology. - : Elsevier BV. - 1873-5150 .- 0887-8994. ; 54, s. 55-63
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Tidskriftsartikel (refereegranskat)abstract
- Abnormalities of early motor development have been reported in autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual developmental disorder, developmental coordination disorder, and other Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE). However, few studies have been conducted with a view to following up a clinically representative cohort of children coming for assessment of motor delay before age two years. We performed a prospective clinical cohort study to examine whether or not early motor delay is often an indication of ESSENCE.
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| 4. |
- Mbelambela, E. P., et al.
(författare)
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Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study
- 2017
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Ingår i: Environmental Health and Preventive Medicine. - : Springer Science and Business Media LLC. - 1342-078X .- 1347-4715. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Road-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa. Methods: A cross-sectional study was conducted from 2015 April 20(th) to May 14(th), whose participants were bus conductors (n = 110), bus drivers (n = 107), taxi-motorcyclists (n = 102) and high school teachers (control group; n = 106). Subjects had completed the American Thoracic Society respiratory symptom questionnaire. Lung function test was performed by spirometry. Air pollutants levels of PM2.5, NO2 and SO2 were measured between 7: 30 and 8: 30 and 16: 30-17: 30 using a portable gas monitor. Multivariate analysis was performed to evaluate the association between occupation exposed to RTE and impaired pulmonary function, after adjustment by plausible confounders. Results: The prevalence of mixed syndrome was 21.9% for bus conductors, 10.9% for bus drivers, 15.4% for taxi-motorcyclists and 7.1% for high school teachers with (p < 0.05). The risk of developing a mixed syndrome was seven times higher among bus conductors [OR = 7.64; 95% CI: 1.83-31.67; p < 0.05] than other groups. Additionally, the prevalence of respiratory syndromes increased with the duration of exposure. Conclusions: Occupation exposed to RTE is associated with impaired pulmonary function and the prevalence of respiratory symptoms among transit workers, especially bus conductors. Furthermore, this association increases with the duration of exposure suggesting the necessity to regulate these categories of occupations and to apply preventives measures.
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| 5. |
- Mbelambela, E. P., et al.
(författare)
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Prevalence of chronic obstructive pulmonary disease (COPD) among Congolese cement workers exposed to cement dust, in Kongo Central Province
- 2018
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Ingår i: Environmental Science and Pollution Research. - : Springer Science and Business Media LLC. - 0944-1344 .- 1614-7499. ; 25:35, s. 35074-35083
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Tidskriftsartikel (refereegranskat)abstract
- Chronic exposure to cement dust may induce adverse health effects, including a significant decrease in lung function. The study investigated whether the prevalence of COPD and respiratory symptoms was associated with working at different tasks exposed to varying levels of cement dust. The cross-sectional study was carried out among 223 exposed and 156 less exposed workers from two cement factories from November 20 to December 15, 2016 in DRC. Workers completed a questionnaire and spirometry was performed. Multivariate analysis was performed to evaluate the association between occupation exposed to cement dust, COPD, and respiratory symptoms, after adjustment for confounders. Morning cough and cough on most days for as much as 3 months each year were significantly higher in the exposed group (p < 0.05) (p = 0.001) than in the less exposed group. As compared to the less exposed group, the prevalence of COPD was higher among the exposed group, 28.2 and 9.6% respectively (p < 0.001). A significant association with COPD, aOR 14.49 (5.33; 39.40), aOR 3.37 (1.44; 7.89), and aOR 3.09 (1.58; 6.05) was found among cleaning, transportation, and production workers, respectively. Working at certain tasks exposed to cement dust is associated with the higher prevalence of COPD and respiratory symptoms. A greater risk is being among cleaning, transportation, and production workers. This suggests the necessity to prioritize the quality of preventive measures in each work area. RONS HL, 1988, BRITISH JOURNAL OF INDUSTRIAL MEDICINE, V45, P368
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| 6. |
- Muchanga, S. M. J., et al.
(författare)
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Association between nausea and vomiting of pregnancy and postpartum depression: the Japan Environment and Children's Study
- 2022
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Ingår i: Journal of Psychosomatic Obstetrics & Gynecology. - : Informa UK Limited. - 0167-482X .- 1743-8942. ; 43:1, s. 2-10
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Postpartum depression (PPD) is a global emotional distress that affects women and their offspring regardless of their culture. The association between nausea and vomiting of pregnancy (NVP) and PPD has been widely described only for the severe form of NVP. We aimed to assess the relationship between PPD and NVP with regards to its severity. Methods: Data from the Japan Environment and Children's Study (JECS), a birth cohort study, were analyzed. PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS). Multiple logistic regression models were performed to assess the association between NVP and PPD. Results: Out of the 80,396 women included in the study 14% had PPD. Among them 4,640 (42.1%) had mild NVP; 3,295 (29.9%) had moderate NVP whereas 1,481 (13.4%) had severe NVP. All forms of NVP were associated with PPD and the association gradually increased with the severity of NVP symptoms with odd ratio (OR): 1.26; 95% confidence interval (CI): 1.18-1.35 for mild, OR: 1.28; 95% CI: 1.19-1.38 for moderate and OR: 1.54; 95% CI: 1.42-1.68 for severe NVP. Conclusion: Japanese women with NVP were more susceptible to develop PPD and the more severe the NVP symptoms were, the greater the risk of PPD. Thus, close monitoring of NVP-affected women is recommended.
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| 7. |
- Muchanga, S. M. J., et al.
(författare)
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Preconception gynecological risk factors of postpartum depression among Japanese women: The Japan Environment and Children's Study (JECS)
- 2017
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 217, s. 34-41
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Tidskriftsartikel (refereegranskat)abstract
- Background: Postpartum depression is one of the major causes of disability among women who are on their childbearing years. Identifying people at risk of postpartum depression may improve its management. The objective of this study was to determine the probable association between postpartum depression and some preconception gynecological morbidities. Methods: Data from a nationwide birth cohort study, the Japan Environment and Children's study (JECS), up to one month of postpartum were analyzed. To assess postpartum depression, the Edinburgh Postnatal Depression Scale (EPDS) was used; 11 preconception gynecological morbidities were considered as risk factors. Covariates included psychiatric illness history, psychosocial factors, some pregnancy adverse outcomes, birth outcomes, socio-demographic and health behavioral factors. Results: Except for the prevalence of previous miscarriage, leiomyoma and polycystic ovarian syndrome, depressive women had more gynecological morbidities compared to non-depressive ones. In logistic regression model, endometriosis (OR, 1.27; 95%CI: 1.15-1.41), dysmenorrhea (OR, 1.13; 95%CI: 1.06-1.21) and abnormal uterine bleeding (OR, 1.21; 95%CI: 1.15-1.29) were associated with postpartum depression. We could not specify in detail which type of gynecological morbidity was associated with postpartum depression, because the current design was not exclusively oriented by the JECS research question. Conclusion: Women with endometriosis and menstrual problems were at risk of developing postpartum depression. This study suggests a perinatal mental health screening for predisposed women.
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| 8. |
- Shigematsu-Locatelli, M., et al.
(författare)
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Maternal pain during pregnancy dose-dependently predicts postpartum depression: The Japan Environment and Children's Study
- 2022
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327. ; 303, s. 346-352
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Tidskriftsartikel (refereegranskat)abstract
- Background: Postpartum depression (PPD) affects women during the first year after delivery. This study investigated the association between prenatal pain (maternal pain during pregnancy) and PPD. Methods: Data were analyzed from the Japan Environment and Children's Study (JECS), a nationwide prospective birth cohort study. Information on prenatal pain was collected twice during pregnancy through self-administered questionnaires. PPD symptoms were assessed using the Edinburgh Postnatal Depression Scale at one month postpartum. Poisson regression analyses were performed to investigate the association between prenatal pain and PPD, with other putative risk factors adjusted in the model. Results: Among 84,801 study subjects, 11,535 (13.6%) were screened as positive for PPD. In the present study, the occurrence of prenatal pain was 69.6 and 84.0% at the first trimester and the second/third trimester, respectively. A positive relationship between any degree of pain and PPD in both the first and the second/third trimester was observed. A significant linear dose-dependent association was also found (Ptrend < 0.001) when the subjects were divided by the severity of pain. Using participants without any pain at either point as a reference, those with persistent pain both at the first and the second/third trimesters showed the highest risk for PPD: aRR = 1.95 (95%CI: 1.76–2.15; p < 0.001). Limitations: No detailed information regarding the type or site of prenatal pain was available in the JECS questionnaires, neither did data concerning delivery and postpartum pain. Conclusions: The study results suggest that prenatal pain is a dose-dependent risk factor for the development of PPD. © 2022 The Authors
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| 9. |
- Yasumitsu-Lovell, Kahoko, et al.
(författare)
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Birth month and infant gross motor development: Results from the Japan Environment and Children's Study (JECS)
- 2021
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 16:5
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Tidskriftsartikel (refereegranskat)abstract
- The association between birth month and neurodevelopmental or psychiatric disorders has been investigated in a number of previous studies; however, the results have been inconsistent. This study investigated the association between birth month and child gross motor development at 6 and 12 months of age in a large cohort of infants (n = 72,203) participating in the Japan Environment and Children's Study (JECS). Gross motor development was assessed using the Ages and Stages Questionnaire (ASQ-3). At 6 months and 12 months, 20.7% and 14.2%, respectively, had ASQ-3 indications of gross motor problems. Birth month was strongly associated with gross motor development at both time points, particularly at 6 months. Summer-born infants had the worst outcomes at both 6 months and 12 months of age. This outcome applied to the ASQ-3 score itself and to the adjusted Relative Risk (aRR), with the highest aRRs (relative to January-born) among August-born (aRR 2.51; 95%CI 2.27-2.78 at 6 months), and June-born (aRR 1.84; 95%CI 1.63-2.09 at 12 months). Boys had better scores than girls both at 6 and 12 months of age. We speculate that seasonal factors-such as maternal vitamin D deficiency and influenza infection-affecting the fetus in early pregnancy might account for the findings.
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| 10. |
- Yasumitsu-Lovell, Kahoko
(författare)
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Pre/Peri/Earl-Life Exposures and Early Child Neurodevelopment: Results from the Japan Environment and Children's Study (JECS)
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Combinations of genetic and environmental factors contribute to aetiologies of neuropsychiatric problems and neurodevelopmental disorders (NDDs) in intricate manners. Among the environmental factors, exposures during the pre-/perinatal periods and early childhood are particularly important. Holistic assessment of additive risks during these periods on child neurodevelopment is crucial for prevention, early detection, and intervention. Equally, when concerns arise about a child’s development, comprehensive/ holistic assessment of neurodevelopment is extremely important as comorbidities are the rule rather than the exception. Aim: The overall aim of this thesis is to examine possible associations between pre-/perinatal and early-life exposures and child neurodevelopment up until 3 years of age. The thesis focuses on the association between pre-/perinatal optimality and child development at 1 month and 3 years of age (Study I), between birth month and gross motor development at age 6 and 12 months (Study II), and between child vitamin D and neurodevelopment at age 2 years (Study III). The fourth study assesses the ability of the ESSENCE-Q used at child age 2.5 years as a screening tool to identify child overall neurodevelopmental problems and relate findings to NDDs diagnosed before 3 years of age (Study IV). Methods: Medical records, blood samples, and self-administered parental questionnaires from the Japan Environment and Children’s Study (JECS), one of the world’s largest ongoing national birth cohort studies (more than 100,000 mother-child dyads), were utilised throughout the four studies. Results: Obstetric reduced optimality scale scores showed dose-response associations with NDDs at child age 3 years (Study I). Summer-born babies lagged behind winter-born babies regarding gross motor development at ages 6 and 12 months (Study II). Low vitamin D level was negatively associated with cognitive and communication development in boys (Study III). Parent-completed ESSENCE-Q was useful for screening out children without neurodevelopmental problems (Study IV). Conclusions: Child neurodevelopment by age 3 years was associated with negative pre-/perinatal factors, seasonality, and, in boys, with low vitamin D levels at age 2 years. These findings could be taken to indicate that better support should be provided for children who experienced adversities in their early life, as early as during the prenatal period. The ESSENCE-Q can probably be used for screening out children without major NDDs.
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