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- Amin Yavari, S., et al.
(författare)
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Layer by layer coating for bio-functionalization of additively manufactured meta-biomaterials
- 2020
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Ingår i: Additive Manufacturing. - : Elsevier BV. - 2214-8604 .- 2214-7810. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- Additive manufacturing has facilitated fabrication of complex and patient-specific metallic meta-biomaterials that offer an unprecedented collection of mechanical, mass transport, and biological properties as well as a fully interconnected porous structure. However, applying meta-biomaterials for addressing unmet clinical needs in orthopedic surgery requires additional surface functionalities that should be induced through tailor-made coatings. Here, we developed multi-functional layer-by-layer coatings to simultaneously prevent implant-associated infections and stimulate bone tissue regeneration. We applied multiple layers of gelatin- and chitosan-based coatings containing either bone morphogenetic protein (BMP)-2 or vancomycin on the surface of selective laser melted porous structures made from commercial pure Titanium (CP Ti) and designed using a triply periodic minimal surface (i.e., sheet gyroid). The additive manufacturing process resulted in a porous structure and met the the design values comparatively. X-ray photoelectron spectroscopy spectra confirmed the presence and composition of the coating layers. The release profiles showed a continued release of both vancomycin and BMP-2 for 2–3 weeks. Furthermore, the developed meta-biomaterials exhibited a very strong antibacterial behavior with up to 8 orders of magnitude reduction in both planktonic and implant-adherent bacteria and no signs of biofilm formation. The osteogenic differentiation of mesenchymal stem cells was enhanced, as shown by two-fold increase in the alkaline phosphatase activity and up to four-fold increase in the mineralization of all experimental groups containing BMP-2. Eight-week subcutaneous implantation in vivo showed no signs of a foreign body response, while connective tissue ingrowth was promoted by the layer-by-layer coating. These results unequivocally confirm the superior multi-functional performance of the developed biomaterials.
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- Rahmani, R., et al.
(författare)
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Effect of oral carbohydrate intake on labor progress : randomized controlled trial
- 2012
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Ingår i: Iranian Journal of Public Health. - : Tehran University of Medical Sciences. - 0304-4556. ; 41:11, s. 59-66
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Tidskriftsartikel (refereegranskat)abstract
- Background: Lack of information regarding biochemical changes in women during labor and its outcomes on maternal and neonatal health still is an unanswered question. This study aims to explore the effectiveness of oral carbohydrate intake during labor on the duration of the active phase and other maternal and neonatal outcomes.Methods: A parallel prospective randomized controlled trial, conducted at the University Affiliated Teaching Hospital in Gonabad. Totally, 190 women were randomly assigned to an intervention (N=87) or control (N=90) group. Inclusion criteria were low-risk women with singleton cephalic presentation; and cervical dilatation 3-4 cm. Randomization was used by random number generator on every day. Odd numbers was used for intervention and even numbers for control group. Intervention was based on the preferences between: 3 medium dates plus 110 ml water; 3 dates plus 110 ml light tea without sugar; or 110 ml orange juice. The protocol is only run once but women ate and drank gradually before second stage of labor. Control group were fasted as routine practice. Neither participants nor care givers or staff could be blinded to group allocation. Differences between duration of the active phase of labor were assessed as primary outcome measure.Results: There was significant difference in the length of second stage of labor (P <.05). The effect size for this variable was 0.48. There were no significant differences in other maternal and neonatal outcomes.Conclusions: Oral intake of carbohydrate was an effective method for shortening the duration of second stage of labor in low-risk women.
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- Uriarte, J L, et al.
(författare)
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Properties of FeNiB-based metallic glasses with primary BCC and FCC crystallisation products.
- 2003
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Ingår i: Journal of Magnetism and Magnetic Materials. - 0304-8853. ; 254-255, s. 532-534
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Tidskriftsartikel (refereegranskat)abstract
- FeSiB tapes have long been commercialised for their excellent soft-magnetic properties but do not manifest a glass transition temperature Tg as crystallisation intervenes. In this work, we present the crystallisation and properties of two Fe-based glasses, which show a glass transition before crystallisation. Using Ni and Co substitution, we can design glasses that form primary FCC or BCC FeNiCo solutions in their first stage of crystallisation followed by the formation of the metastable (FeNiCo)4B (C6Cr23-type cF116) intermetallic phase. Thermal and structural and magnetic properties were compared during heat treatment.
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- Bahrami, Alireza, et al.
(författare)
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Analysis of composite shear walls with a gap between reinforced concrete wall and steel frame
- 2020
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Ingår i: Archives of Civil Engineering. - 1230-2945. ; 66:1, s. 41-53
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Tidskriftsartikel (refereegranskat)abstract
- In this research, nonlinear analysis of composite shear walls (CSWs) with a gap between reinforced concrete wall and steel frame is investigated under cyclic loading by the use of the finite element method (FEM) software ABAQUS. For the purpose of the verification, an experimental test is modelled and comparison of its obtained result with that of the experimental test demonstrates an inconsiderable difference between them; therefore, the reasonable accuracy of the modelling is revealed. Then, effects of different parameters on the behaviour of the CSWs are examined. Gap size between reinforced concrete wall and steel frame, reinforcement percentage, steel sections of beams and columns, and existence of reinforced concrete wall are considered as parameters. It is concluded that change of the parameters affects the ultimate strength, ductility, and energy dissipation of the system. A steel shear wall (SSW) is also modelled and compared with the CSWs. Buckling of the walls is presented as well.
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