| 1. |
|
|
| 2. |
- Cheng, Anying, et al.
(författare)
-
Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients
- 2020
-
Ingår i: International Journal of Antimicrobial Agents. - : ELSEVIER. - 0924-8579 .- 1872-7913. ; 56:3
-
Tidskriftsartikel (refereegranskat)abstract
- The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher ( P < 0.0 0 01). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (logrank, P 0.0 0 01). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN 4.6 mmol/L and D-dimer > 0.845 mu g/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients. (c) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
|
|
| 3. |
- Klionsky, Daniel J., et al.
(författare)
-
Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
-
Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
-
Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
|
|
| 4. |
- Wu, Ying, et al.
(författare)
-
A 0.13µm CMOS ΔΣ PLL FM Transmitter
- 2011
-
Ingår i: [Host publication title missing]. - 9781457705144
-
Konferensbidrag (refereegranskat)abstract
- A short range FM transmitter is presented. It uses an architecture where the output frequency of a phase locked loop (PLL) is modulated by varying the division number of the feedback divider, using the 1-bit output of a ΔΣ ADC. The measured total harmonic distortion (THD) plus noise is less than 1% at 75 kHz deviation. The transmitter is fully integrated in a 0.13µm CMOS process and the core area is 0.24 mm2. The current consumption is 4.4mA from a 1.2V supply.
|
|
| 5. |
- Ye, Dawei, et al.
(författare)
-
A Wide Bandwidth Fractional-N Synthesizer for LTE with Phase Noise Cancellation Using a Hybrid- -DAC and Charge Re-timing
- 2013
-
Ingår i: [Host publication title missing]. - 0271-4310 .- 2158-1525. ; , s. 169-172
-
Konferensbidrag (refereegranskat)abstract
- This paper presents a 1MHz bandwidth, ΔƩ fractional-N PLL as the frequency synthesizer for LTE. A noise cancellation path composed of a novel hybrid ΔƩ DAC with 9 output bits is incorporated into the PLL in order to cancel the out-of-band phase noise caused by the quantization error. Further, a re-timing circuit is proposed to reduce the nonlinearity in the Charge Pump and provide pulse shaping signals to decrease the charge mismatch. Therefore, a wide loop bandwidth can be obtained while keeping reasonable performance of out-of-band phase noise. The proposed synthesizer is simulated in 90nm CMOS process, consuming 20.96mA from a 1 V supply.
|
|
