| 1. |
- Pattaro, Cristian, et al.
(författare)
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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| 2. |
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| 3. |
- Chapron, Guillaume, et al.
(författare)
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Testing a global standard for quantifying species recovery and assessing conservation impact
- 2021
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Ingår i: Conservation Biology. - : Wiley. - 0888-8892 .- 1523-1739. ; 35, s. 1833-1849
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Tidskriftsartikel (refereegranskat)abstract
- Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a "Green List of Species" (now the IUCN Green Status of Species). A draft Green Status framework for assessing species' progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement against benchmarks of species' viability, functionality, and preimpact distribution) to determine current species recovery status (herein species recovery score) and application of that method to estimate past and potential future impacts of conservation based on 4 metrics (conservation legacy, conservation dependence, conservation gain, and recovery potential). We tested the framework with 181 species representing diverse taxa, life histories, biomes, and IUCN Red List categories (extinction risk). Based on the observed distribution of species' recovery scores, we propose the following species recovery categories: fully recovered, slightly depleted, moderately depleted, largely depleted, critically depleted, extinct in the wild, and indeterminate. Fifty-nine percent of tested species were considered largely or critically depleted. Although there was a negative relationship between extinction risk and species recovery score, variation was considerable. Some species in lower risk categories were assessed as farther from recovery than those at higher risk. This emphasizes that species recovery is conceptually different from extinction risk and reinforces the utility of the IUCN Green Status of Species to more fully understand species conservation status. Although extinction risk did not predict conservation legacy, conservation dependence, or conservation gain, it was positively correlated with recovery potential. Only 1.7% of tested species were categorized as zero across all 4 of these conservation impact metrics, indicating that conservation has, or will, play a role in improving or maintaining species status for the vast majority of these species. Based on our results, we devised an updated assessment framework that introduces the option of using a dynamic baseline to assess future impacts of conservation over the short term to avoid misleading results which were generated in a small number of cases, and redefines short term as 10 years to better align with conservation planning. These changes are reflected in the IUCN Green Status of Species Standard.
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| 4. |
- Guidini Lopes, Ivã, et al.
(författare)
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Recirculating frass from food waste bioconversion using black soldier fly larvae: Impacts on process efficiency and product quality
- 2024
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Ingår i: Journal of Environmental Management. - 0301-4797 .- 1095-8630. ; 366
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Tidskriftsartikel (refereegranskat)abstract
- Biowaste generation is increasing worldwide and inadequate disposal has strong negative impacts on food systems and ecosystems. Biodigestion of biowaste using black soldier fly (Hermetia illucens) larvae (BSFL) generates valuable by-products such as animal feed (larval biomass) and organic fertiliser (frass). However, the latter is typically unstable immediately after waste conversion and is thus unsafe for use as a fertilizer in terms of maturity. This study evaluated recirculation of frass within bioconversion of post-consumer food waste (FW) as a dietary component for BSFL to improve the quality of the subsequent frass obtained. Frass was introduced at increasing inclusion levels replacing food waste (2.5–100% on wet-weight basis) as part of the larvae's feeding substrate. Bioconversion efficiency and material reduction were significantly reduced by frass inclusion, while larval yield per experimental unit remained unchanged. When considering only the waste component in the larval diet, larval yield (dry-weight basis) ranged between 207 (0% frass inclusion) and 403 (40% frass inclusion) kg tonne FW−1, thus increasing by up to 94% at higher frass inclusion. With increasing dietary inclusion rate of frass from 0% to 100%, crude protein content of larval biomass increased by 41%, while fat content was reduced by 32%. The recirculated frass (obtained after including frass in the larval diet) had elevated concentrations of P, K, S, Na and B and around 6% lower organic matter content, demonstrating a higher degree of decomposition. Frass inclusion in the larval diet generated recirculated frass that were more stable and mature, as indicated by self-heating capacity, CO2 and NH3 volatilisation, seed germination bioassays and other parameters. It was concluded that frass recirculation improves waste bioconversion efficiency in relation to food waste unit, as well as larval biomass and frass quality, ensuring safer use as a fertilizer.
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| 5. |
- Lopes, Iva Guidini, et al.
(författare)
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Frass derived from black soldier fly treatment of biodegradable wastes. A critical review and future perspectives
- 2022
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Ingår i: Waste Management. - : Elsevier BV. - 0956-053X .- 1879-2456. ; 142, s. 65-76
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Forskningsöversikt (refereegranskat)abstract
- Inadequately treated biodegradable waste is considered an environmental, social and economic threat worldwide, which call for great attention. Waste treatment with larvae of the black soldier fly (BSF, Hermetia illucens) complies with the concepts of circular economy, as it enables the transformation of these wastes into marketable products, closing loops and promoting circularity. The processing residues of the treatment (frass) is constantly generated in waste management facilities in large volumes, and this product can be used as an organic fertilizer in agriculture, stimulating a transition to a circular economy. However, many aspects related to frass are still unknown, such as its varying composition of nutrients, microorganisms and bioactive compounds, its post processing requirements for improved biological stabilization, its behavior in the soil and action in the plants' metabolism, among other aspects. In this review article, we highlight the potential of frass from BSF larvae treatment of biodegradable waste in the world market regarding its possible use as a fertilizer, summarize recent results with this novel product and point towards future research perspectives.
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| 6. |
- Sani, Md Nasir Hossain, et al.
(författare)
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Synergistic effects of biochar and potassium co-application on growth, physiological attributes, and antioxidant defense mechanisms of wheat under water deficit conditions
- 2024
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Ingår i: Plant stress. - 2667-064X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Global wheat production faces a severe threat from drought stress, necessitating innovative strategies for enhanced crop resilience. This study examined the synergistic impact of biochar and potassium co-application on the growth, physiological attributes, and antioxidant defense system of wheat under water deficit conditions at crown root initiation (CRI), anthesis, and grain development stage. Drought-induced reactive oxygen species (ROS) accumulation, particularly pronounced at the CRI stage, adversely affected all growth stages. At CRI, co-application of biochar and foliar potassium delivered significant improvements in growth parameters, including increased plant height (15.4%), spike length (50%), grain yield (43.0%), photosynthetic performance (chlorophyll content 125.8%), and relative water content (11.2%), compared to untreated drought-exposed counterparts. The combined application of biochar and potassium effectively reduced hydrogen peroxide production, electrolyte leakage, proline accumulation, and malondialdehyde generation, while increasing relative water content and glutathione levels under both well-irrigated and drought stress conditions. Furthermore, the combined biochar and potassium treatment was effective in mitigating oxidative stress and enhancing physiological resilience in wheat, particularly during the anthesis stage of drought stress. Specifically, the combined treatment ameliorated the effects of drought by reducing ROS levels through enhanced antioxidant enzyme activities and elevating osmoprotectants levels. The synergistic modulation of tissue osmotic balance and relative water content holds promise for mitigating drought-induced stress, offering an innovative and practical strategy for resilient wheat production in water-limited environments.
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| 7. |
- Sani, Md Nasir Hossain, et al.
(författare)
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Waste-derived nanobiochar: a new avenue towards sustainable agriculture, environment, and circular bioeconomy
- 2023
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Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 905
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Tidskriftsartikel (refereegranskat)abstract
- The greatest challenge for the agriculture sector in the twenty-first century is to increase agricultural production to feed the burgeoning global population while maintaining soil health and the integrity of the agroecosystem. Currently, the application of biochar is widely implemented as an effective means for boosting sustainable agriculture while having a negligible influence on ecosystems and the environment. In comparison to traditional biochar, nano-biochar (nano-BC) boasts enhanced specific surface area, adsorption capacity, and mobility properties within soil, allowing it to promote soil properties, crop growth, and environmental remediation. Additionally, carbon sequestration and reduction of methane and nitrous oxide emissions from agriculture can be achieved with nano-BC applications, contributing to climate change mitigation. Nonetheless, due to costeffectiveness, sustainability, and environmental friendliness, waste-derived nano-BC may emerge as the most viable alternative to conventional waste management strategies, contributing to the circular bioeconomy and the broader goal of achieving the Sustainable Development Goals (SDGs). However, it's important to note that research on nano-BC is still in its nascent stages. Potential risks, including toxicity in aquatic and terrestrial environments, necessitate extensive field investigations. This review delineates the potential of waste-derived nano-BC for sustainable agriculture and environmental applications, outlining current advancements, challenges, and possibilities in the realms from a sustainability and circular bioeconomy standpoint.
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| 8. |
- Yong, Jean W.H
(författare)
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A review on mechanisms and prospects of endophytic bacteria in biocontrol of plant pathogenic fungi and their plant growth promoting activities
- 2024
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Ingår i: Heliyon. - 2405-8440. ; 10
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Forskningsöversikt (refereegranskat)abstract
- Endophytic bacteria, living inside plants, are competent plant colonizers, capable of enhancing immune responses in plants and establishing a symbiotic relationship with them. Endophytic bacteria are able to control phytopathogenic fungi while exhibiting plant growth-promoting activity. Here, we discussed the mechanisms of phytopathogenic fungi control and plant growth-promoting actions discovered in some major groups of beneficial endophytic bacteria such as Bacillus, Paenibacillus, and Pseudomonas. Most of the studied strains in these genera were isolated from the rhizosphere and soils, and a more extensive study of these endophytic bacteria is needed. It is essential to understand the underlying biocontrol and plant growth-promoting mechanisms and to develop an effective screening approach for selecting potential endophytic bacteria for various applications. We have suggested a screening strategy to identify potentially useful endophytic bacteria based on mechanistic phenomena. The discovery of endophytic bacteria with useful biocontrol and plant growth-promoting characteristics is essential for developing sustainable agriculture.
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| 9. |
- Yong, Jean W.H
(författare)
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Agricultural waste-based modified biochars differentially affected the soil properties, growth, and nutrient accumulation by maize (Zea mays L.) plants
- 2024
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Ingår i: BMC Plant Biology. - 1471-2229. ; 24
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Tidskriftsartikel (refereegranskat)abstract
- Biochar (BC) is an organic compound formed by the pyrolysis of organic wastes. Application of BCs as soil amendments has many benefits including carbon sequestration, enhanced soil fertility and sustainable agriculture production. In the present study, we acidified the different BCs prepared from rice straw, rice husk, wheat straw, cotton stalk, poultry manure, sugarcane press mud and vegetable waste; following which, we applied them in a series of pot experiments. Comparisons were made between acidified and non- acidified BCs for their effects on seed germination, soil properties (EC, pH) nutrient contents (P, K, Na) and organic matter. The treatments comprised of a control, and all above-described BCs (acidified as well as non-acidified) applied to soil at the rate of 1% (w/w). The maize crop was selected as a test crop. The results showed that acidified poultry manure BC significantly improved germination percentage, shoot length, and biomass of maize seedlings as compared to other BCs and their respective control plants. However, acidified BCs caused a significant decrease in nutrient contents (P, K, Na) of soil,maize seedlings, and the soil organic matter contents as compared to non- acidified BCs. But when compared with control treatments, all BCs treatments (acidified and non-acidified) delivered higher levels of nutrients and organic matter contents. It was concluded that none of the BCs (acidified and non-acidified) had caused negative effect on soil conditions and growth of maize. In addition, the acidification of BC prior to its application to alkaline soils might had altered soil chemistry and delivered better maize growth. Moving forward, more research is needed to understand the long-term effects of modified BCs on nutrient dynamics in different soils. In addition, the possible effects of BC application timings, application rates, particle size, and crop species have to be evaluated systemtically.
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| 10. |
- Yong, Jean W.H
(författare)
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Alleviating salinity stress in canola (Brassica napus L.) through exogenous application of salicylic acid
- 2024
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Ingår i: BMC Plant Biology. - 1471-2229. ; 24
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Tidskriftsartikel (refereegranskat)abstract
- Canola, a vital oilseed crop, is grown globally for food and biodiesel. With the enormous demand for growing various crops, the utilization of agriculturally marginal lands is emerging as an attractive alternative, including brackish-saline transitional lands. Salinity is a major abiotic stress limiting growth and productivity of most crops, and causing food insecurity. Salicylic acid (SA), a small-molecule phenolic compound, is an essential plant defense phytohormone that promotes immunity against pathogens. Recently, several studies have reported that SA was able to improve plant resilience to withstand high salinity. For this purpose, a pot experiment was carried out to ameliorate the negative effects of sodium chloride (NaCl) on canola plants through foliar application of SA. Two canola varieties Faisal (V1) and Super (V2) were assessed for their growth performance during exposure to high salinity i.e. 0 mM NaCl (control) and 200 mM NaCl. Three levels of SA (0, 10, and 20 mM) were applied through foliar spray. The experimental design used for this study was completely randomized design (CRD) with three replicates. The salt stress reduced the shoot and root fresh weights up to 50.3% and 47% respectively. In addition, foliar chlorophyll a and b contents decreased up to 61–65%. Meanwhile, SA treatment diminished the negative effects of salinity and enhanced the shoot fresh weight (49.5%), root dry weight (70%), chl. a (36%) and chl. b (67%). Plants treated with SA showed an increased levels of both enzymatic i.e. (superoxide dismutase (27%), peroxidase (16%) and catalase (34%)) and non-enzymatic antioxidants i.e. total soluble protein (20%), total soluble sugar (17%), total phenolic (22%) flavonoids (19%), anthocyanin (23%), and endogenous ascorbic acid (23%). Application of SA also increased the levels of osmolytes i.e. glycine betaine (31%) and total free proline (24%). Salinity increased the concentration of Na+ ions and concomitantly decreased the K+ and Ca2+ absorption in canola plants. Overall, the foliar treatments of SA were quite effective in reducing the negative effects of salinity. By comparing both varieties of canola, it was observed that variety V2 (Super) grew better than variety V1 (Faisal). Interestingly, 20 mM foliar application of SA proved to be effective in ameliorating the negative effects of high salinity in canola plants.
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