| 1. |
-
- 2019
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
- Huang, Hongyun, et al.
(författare)
-
Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
- 2018
-
Ingår i: Cell Transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 27:2, s. 310-324
-
Forskningsöversikt (refereegranskat)abstract
- Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.
|
|
| 3. |
- Konold, Patrick E., et al.
(författare)
-
3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers
- 2023
-
Ingår i: IUCrJ. - : International Union Of Crystallography. - 2052-2525. ; 10, s. 662-670
-
Tidskriftsartikel (refereegranskat)abstract
- X-ray free-electron lasers (XFELs) can probe chemical and biological reactions as they unfold with unprecedented spatial and temporal resolution. A principal challenge in this pursuit involves the delivery of samples to the X-ray interaction point in such a way that produces data of the highest possible quality and with maximal efficiency. This is hampered by intrinsic constraints posed by the light source and operation within a beamline environment. For liquid samples, the solution typically involves some form of high-speed liquid jet, capable of keeping up with the rate of X-ray pulses. However, conventional jets are not ideal because of radiation-induced explosions of the jet, as well as their cylindrical geometry combined with the X-ray pointing instability of many beamlines which causes the interaction volume to differ for every pulse. This complicates data analysis and contributes to measurement errors. An alternative geometry is a liquid sheet jet which, with its constant thickness over large areas, eliminates the problems related to X-ray pointing. Since liquid sheets can be made very thin, the radiation-induced explosion is reduced, boosting their stability. These are especially attractive for experiments which benefit from small interaction volumes such as fluctuation X-ray scattering and several types of spectroscopy. Although their use has increased for soft X-ray applications in recent years, there has not yet been wide-scale adoption at XFELs. Here, gas-accelerated liquid sheet jet sample injection is demonstrated at the European XFEL SPB/SFX nano focus beamline. Its performance relative to a conventional liquid jet is evaluated and superior performance across several key factors has been found. This includes a thickness profile ranging from hundreds of nanometres to 60 nm, a fourfold increase in background stability and favorable radiation-induced explosion dynamics at high repetition rates up to 1.13 MHz. Its minute thickness also suggests that ultrafast single-particle solution scattering is a possibility.
|
|
| 4. |
- Konold, Patrick E., et al.
(författare)
-
Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
- 2024
-
Ingår i: NATURE METHODS. - : NATURE PORTFOLIO. - 1548-7091 .- 1548-7105.
-
Tidskriftsartikel (refereegranskat)abstract
- Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce microsecond time-series of protein scattering with exceptionally low noise levels of 0.001%. We demonstrate the approach by examining J alpha helix unfolding of a light-oxygen-voltage photosensory domain. This time-resolved acquisition strategy is easy to implement and widely applicable for direct observation of structural dynamics of many biochemical processes. The MHz repetition rates available at second-generation X-ray free-electron lasers enable the collection of microsecond time-resolved X-ray scattering data with exceptionally low noise, providing insights into protein structural dynamics.
|
|
| 5. |
- Konold, Patrick, et al.
(författare)
-
Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Detecting microsecond structural perturbations in biomolecules has wide relevance inbiology, chemistry, and medicine. Here, we show how MHz repetition rates at X-ray freeelectron lasers (XFELs) can be used to produce microsecond time-series of proteinscattering with exceptionally low noise levels of 0.001%. We demonstrate the approach byderiving new mechanistic insight into Jɑ helix unfolding of a Light-Oxygen-Voltage (LOV)photosensory domain. This time-resolved acquisition strategy is easy to implement andwidely applicable for direct observation of structural dynamics of many biochemicalprocesses.
|
|
| 6. |
- Liu, Cheng, et al.
(författare)
-
Tuning the composition of heavy metal-free quaternary quantum dots for improved photoelectrochemical performance
- 2021
-
Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry. - 2050-7488 .- 2050-7496. ; 9:9, s. 5825-5832
-
Tidskriftsartikel (refereegranskat)abstract
- Colloidal quantum dots (QDs) are promising building blocks towards the development of cost-effective and high-efficiency photoelectrochemical (PEC) cells. Unfortunately, the frequent use of QDs possessing heavy metals (e.g. Cd and Pb) in state-of-the-art QD-based PEC technologies is a major obstacle regarding their future commercial perspective. In this work, we synthesized heavy metal-free quaternary CuZnInS3 (CZIS) with variable Cu : Zn ratios and fabricated corresponding QDs-PEC devices via a facile chemical bath deposition (CBD) technique. It is revealed that the tuned CZIS (1Zn) QDs (i.e. Cu : Zn ratio of 1 : 1) can result in optimized optical properties including enhanced quantum yield, suppressed nonradiative recombination and extended excitonic lifetime. Accordingly, as-fabricated CZIS (1Zn) QD-based photoanodes demonstrated increased charge transfer rate and decreased electron transport resistance for improved PEC performance. The results indicate that tuning the composition of heavy metal-free multinary QDs is one of the promising pathways to achieve eco-friendly and high-performance PEC systems for solar hydrogen production.
|
|
| 7. |
- Miao, Yanfeng, et al.
(författare)
-
Stable and bright formamidinium-based perovskite light-emitting diodes with high energy conversion efficiency
- 2019
-
Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Solution-processable perovskites show highly emissive and good charge transport, making them attractive for low-cost light-emitting diodes (LEDs) with high energy conversion efficiencies. Despite recent advances in device efficiency, the stability of perovskite LEDs is still a major obstacle. Here, we demonstrate stable and bright perovskite LEDs with high energy conversion efficiencies by optimizing formamidinium lead iodide films. Our LEDs show an energy conversion efficiency of 10.7%, and an external quantum efficiency of 14.2% without outcoupling enhancement through controlling the concentration of the precursor solutions. The device shows low efficiency droop, i.e. 8.3% energy conversion efficiency and 14.0% external quantum efficiency at a current density of 300 mA cm(-2), making the device more efficient than state-of-the-art organic and quantum-dot LEDs at high current densities. Furthermore, the half-lifetime of device with benzylamine treatment is 23.7 hr under a current density of 100 mA cm(-2), comparable to the lifetime of near-infrared organic LEDs.
|
|
| 8. |
- Tong, Xin, et al.
(författare)
-
Boosting the performance of eco-friendly quantum dots-based photoelectrochemical cells via effective surface passivation
- 2020
-
Ingår i: Nano Energy. - : Elsevier. - 2211-2855 .- 2211-3282. ; 76
-
Tidskriftsartikel (refereegranskat)abstract
- Photoelectrochemical (PEC) cells fabricated using environment-friendly colloidal quantum dots (QDs) are promising optoelectronic devices for future practical solar-to-hydrogen conversion. However, the majority of current eco-friendly QDs-based PEC cells exhibited low efficiency mainly due to the charge trapping at QDs’ surface states and interfacial recombination processes in devices. Here, eco-friendly AgInS2 (AIS) QDs-based PEC cells passivated with variable ZnS layers were fabricated and the effects of ZnS surface passivation on corresponding device performance were investigated. It is demonstrated that optimizing the thickness of the ZnS passivation layers can largely suppress the charge trapping/recombination and enhance the electron injection efficiency in the PEC devices, leading to a saturated photocurrent density of ∼5.7 mA/cm2 under standard AM 1.5 G solar illumination. Increasing the thickness of ZnS passivation layers can further inhibit the photocorrosion and give rise to higher device stability. These results indicate that ZnS surface passivation is a facile and efficient technique to boost the performance of eco-friendly QDs-based PEC cells.
|
|
| 9. |
- Wang, Cheng-Xiang, et al.
(författare)
-
On the Road to 6G: Visions, Requirements, Key Technologies, and Testbeds
- 2023
-
Ingår i: IEEE Communications Surveys and Tutorials. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1553-877X. ; 25:2, s. 905-974
-
Tidskriftsartikel (refereegranskat)abstract
- Fifth generation (5G) mobile communication systems have entered the stage of commercial deployment, providing users with new services, improved user experiences as well as a host of novel opportunities to various industries. However, 5G still faces many challenges. To address these challenges, international industrial, academic, and standards organizations have commenced research on sixth generation (6G) wireless communication systems. A series of white papers and survey papers have been published, which aim to define 6G in terms of requirements, application scenarios, key technologies, etc. Although ITU-R has been working on the 6G vision and it is expected to reach a consensus on what 6G will be by mid-2023, the related global discussions are still wide open and the existing literature has identified numerous open issues. This paper first provides a comprehensive portrayal of the 6G vision, technical requirements, and application scenarios, covering the current common understanding of 6G. Then, a critical appraisal of the 6G network architecture and key technologies is presented. Furthermore, existing testbeds and advanced 6G verification platforms are detailed for the first time. In addition, future research directions and open challenges are identified to stimulate the on-going global debate. Finally, lessons learned to date concerning 6G networks are discussed.
|
|
| 10. |
- Wang, Kuan, et al.
(författare)
-
Threshold switching memristor-based stochastic neurons for probabilistic computing
- 2021
-
Ingår i: Materials Horizons. - : Royal Society of Chemistry. - 2051-6347 .- 2051-6355. ; 8:2, s. 619-629
-
Tidskriftsartikel (refereegranskat)abstract
- Biological neurons exhibit dynamic excitation behavior in the form of stochastic firing, rather than stiffly giving out spikes upon reaching a fixed threshold voltage, which empowers the brain to perform probabilistic inference in the face of uncertainty. However, owing to the complexity of the stochastic firing process in biological neurons, the challenge of fabricating and applying stochastic neurons with bio-realistic dynamics to probabilistic scenarios remains to be fully addressed. In this work, a novel CuS/GeSe conductive-bridge threshold switching memristor is fabricated and singled out to realize electronic stochastic neurons, which is ascribed to the similarity between the stochastic switching behavior observed in the device and that of biological ion channels. The corresponding electric circuit of a stochastic neuron is then constructed and the probabilistic firing capacity of the neuron is utilized to implement Bayesian inference in a spiking neural network (SNN). The application prospects are demonstrated on the example of a tumor diagnosis task, where common fatal diagnostic errors of a conventional artificial neural network are successfully circumvented. Moreover, in comparison to deterministic neuron-based SNNs, the stochastic neurons enable SNNs to deliver an estimate of the uncertainty in their predictions, and the fidelity of the judgement is drastically improved by 81.2%.
|
|
