| 1. |
- Hill, S C, et al.
(författare)
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Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis
- 2005
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Ingår i: Journal of Immunology. - 1550-6606. ; 174:1, s. 41-50
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in activation of the NF-kappaB and MAPK signaling pathways and up-regulation of cell surface markers and intracellular molecules associated with Ag processing and presentation. Concomitantly, the CD154-induced activation of CD40 in carcinoma cells was found to directly influence susceptibility to CTL-mediated killing. Thus, CD40 stimulation in cervical carcinoma cell lines expressing a TAP-dependent human papillomavirus 16 E6 Ag epitope resulted in their enhanced killing by specific CTLs. However, CD154 treatment of carcinoma cells expressing proteasome-dependent but TAP-independent Ags from the EBV-encoded BRLF1 and BMLF1 failed to increase tumor cell lysis by specific CTLs. Moreover, we demonstrate that chemotherapeutic agents that suppress protein synthesis and reverse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-binding protein from the initiation factor eukaryotic initiation factor 4E, such as 5-fluorouracil, etoposide, and quercetin, dramatically increase the susceptibility of cervical carcinoma cells to CD40L-induced apoptosis. Taken together, these observations demonstrate the functional expression of CD40 in epithelial tumors of the cervix and support the clinical exploitation of the CD40 pathway for the treatment of cervical cancer through its multiple effects on tumor cell growth, apoptosis, and immune recognition.
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| 2. |
- Delatolla, A., et al.
(författare)
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Challenging Institutional Racism in International Relations and Our Profession: Reflections, Experiences, and Strategies
- 2021
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Ingår i: Millennium-Journal of International Studies. - : SAGE Publications. - 0305-8298 .- 1477-9021. ; 50:1, s. 110-148
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Tidskriftsartikel (refereegranskat)abstract
- Attempts to create a more inclusive discipline and profession have been commended by many and derided by some. While these attempts have pushed for change, particularly with regards to more equal representation of gender and race among faculty, policies aimed at creating a more inclusive environment are often tokenistic, administrative and bureaucratic, and fail to address structural and institutional practices and norms. Moreover, the administrative and bureaucratic policies put into place are generally targeted at a single categorical group, failing to take into account the manner in which identities are intersecting and overlapping. Equality, Diversity and Inclusion often gets driven by Human Resources and Marketing rather than owned by the wider university. This forum draws from a variety of contributions that focus on describing the lived realities of institutional racism, its intersections with other forms of discrimination, and strategies for change. In putting together this forum, we do not aim to create a checklist of practical steps. Instead, we hope to signpost and make visible the successes and failures of previous challenges and future possibilities that must be taken by both faculty and administrations.
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