| 1. |
- Fan, Qunping, 1989, et al.
(författare)
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A Non-Conjugated Polymer Acceptor for Efficient and Thermally Stable All-Polymer Solar Cells
- 2020
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 59:45, s. 19835-19840
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Tidskriftsartikel (refereegranskat)abstract
- A non-conjugated polymer acceptor PF1-TS4 was firstly synthesized by embedding a thioalkyl segment in the mainchain, which shows excellent photophysical properties on par with a fully conjugated polymer, with a low optical band gap of 1.58 eV and a high absorption coefficient >105 cm−1, a high LUMO level of −3.89 eV, and suitable crystallinity. Matched with the polymer donor PM6, the PF1-TS4-based all-PSC achieved a power conversion efficiency (PCE) of 8.63 %, which is ≈45 % higher than that of a device based on the small molecule acceptor counterpart IDIC16. Moreover, the PF1-TS4-based all-PSC has good thermal stability with ≈70 % of its initial PCE retained after being stored at 85 °C for 180 h, while the IDIC16-based device only retained ≈50 % of its initial PCE when stored at 85 °C for only 18 h. Our work provides a new strategy to develop efficient polymer acceptor materials by linkage of conjugated units with non-conjugated thioalkyl segments.
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| 2. |
- Cao, Zhiguo, et al.
(författare)
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Economic status as a determinant of national PCDD/PCDF releases and implications for PCDD/PCDF reduction
- 2013
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Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 91:3, s. 328-335
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Tidskriftsartikel (refereegranskat)abstract
- The annual releases of polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans (PCDD/PCDF) from 68 countries/regions were investigated by correlating quantitative emissions with economic status of the nations. The national dioxin/furan inventories were developed using the PCDD/PCDF Standardized Toolldt, which presents the quantitative releases from ten major source groups to five release vectors. The correlation between intensity of PCDDIPCDF release and economic status was discussed and the influence of economic status on composition of five release vectors and ten source groups was studied. As PCDD/PCDF are mainly released from human activities to environmental matrices, release per person (RpP) and release per unit area (RpA) are defined to reflect release burden (Donor) and contamination burden (Receptor), respectively. Based on these two concepts, International PCDD/PCDF Reduction Burden is characterized by burden quotient (BQ) and a calculation model is established. The numbers of countries/regions with high, moderate and low International PCDD/PCDF Reduction Burden were 19,31 and 18, respectively. The information in this paper can be used for politicians to develop legislations to improve International PCDD/PCDF Reduction.
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| 3. |
- Gan, Haiyun, et al.
(författare)
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Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress
- 2017
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Ingår i: Molecular Cell. - : Elsevier. - 1097-2765 .- 1097-4164. ; 68:2, s. 446-455
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Tidskriftsartikel (refereegranskat)abstract
- The checkpoint kinase Rad53 is activated during replication stress to prevent fork collapse, an essential but poorly understood process. Here we show that Rad53 couples leading- and lagging-strand synthesis under replication stress. In rad53-1 cells stressed by dNTP depletion, the replicative DNA helicase, MCM, and the leading-strand DNA polymerase, Pol ε, move beyond the site of DNA synthesis, likely unwinding template DNA. Remarkably, DNA synthesis progresses further along the lagging strand than the leading strand, resulting in the exposure of long stretches of single-stranded leading-strand template. The asymmetric DNA synthesis in rad53-1 cells is suppressed by elevated levels of dNTPs in vivo, and the activity of Pol ε is compromised more than lagging-strand polymerase Pol δ at low dNTP concentrations in vitro. Therefore, we propose that Rad53 prevents the generation of excessive ssDNA under replication stress by coordinating DNA unwinding with synthesis of both strands.
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| 4. |
- Ghalwash, Mohamed, et al.
(författare)
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Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood : a prospective cohort study
- 2023
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Ingår i: The Lancet Child and Adolescent Health. - 2352-4642. ; 7:4, s. 261-268
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Tidskriftsartikel (refereegranskat)abstract
- Background: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We aimed to assess whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents aged 10−18 years with an increased risk of developing type 1 diabetes. Methods: Data were harmonised from prospective studies from Finland (the Diabetes Prediction and Prevention study), Germany (the BABYDIAB study), and the USA (Diabetes Autoimmunity Study in the Young and the Diabetes Evaluation in Washington study). Autoantibodies against insulin, glutamic acid decarboxylase, and insulinoma-associated protein 2 were measured at each follow-up visit. Children who were lost to follow-up or diagnosed with type 1 diabetes before 10 years of age were excluded. Inverse probability censoring weighting was used to include data from remaining participants. Sensitivity and the positive predictive value of these autoantibodies, tested at one or two ages, to predict type 1 diabetes by the age of 18 years were the main outcomes. Findings: Of 20 303 children with an increased type 1 diabetes risk, 8682 were included for the analysis with inverse probability censoring weighting. 1890 were followed up to 18 years of age or developed type 1 diabetes between the ages of 10 years and 18 years, and their median follow-up was 18·3 years (IQR 14·5–20·3). 442 (23·4%) of 1890 adolescents were positive for at least one islet autoantibody, and 262 (13·9%) developed type 1 diabetes. Time from seroconversion to diabetes diagnosis increased by 0·64 years (95% CI 0·34–0·95) for each 1-year increment of diagnosis age (Pearson's correlation coefficient 0·88, 95% CI 0·50–0·97, p=0·0020). The median interval between the last prediagnostic sample and diagnosis was 0·3 years (IQR 0·1–1·3) in the 227 participants who were autoantibody positive and 6·8 years (1·6–9·9) for the 35 who were autoantibody negative. Single screening at the age of 10 years was 90% (95% CI 86–95) sensitive, with a positive predictive value of 66% (60–72) for clinical diabetes. Screening at two ages (10 years and 14 years) increased sensitivity to 93% (95% CI 89–97) but lowered the positive predictive value to 55% (49–60). Interpretation: Screening of adolescents at risk for type 1 diabetes only once at 10 years of age for islet autoantibodies was highly effective to detect type 1 diabetes by the age of 18 years, which in turn could enable prevention of diabetic ketoacidosis and participation in secondary prevention trials. Funding: JDRF International.
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| 5. |
- Shen, Zhou, et al.
(författare)
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Optimal Power Allocations for 5G Non-Orthogonal Multiple Access with Half/Full Duplex Relaying
- 2019
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Ingår i: ICC 2019 - 2019 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS (ICC). - : IEEE. - 9781538680889
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Konferensbidrag (refereegranskat)abstract
- Recently, power allocation has attracted more and more attention in order to optimize the performance of nonorthogonal multiple access (NOMA) systems. Different from existing works, the power allocation problems are investigated for cooperative NOMA systems with dedicated amplify-and-forward half-duplex relay (NOMA-HDR) and full-duplex relay (NOMA-FDR). From the fairness standpoint, the power allocation problems are formulated to maximize the minimum achievable user rate in the considered systems. The problems for both NOMA-HDR and NOMA-FDR systems with two-user and M-user are addressed. The closed-form power allocation policy of two-user NOMA-HDR system is obtained. Also, the optimal numerical power allocation policies for two-user NOMA-FDR and M-user NOMA-HDR systems are obtained. In addition, the problem for M-user NOMA-FDR systems is solved in noise-limited environment. Simulation results show that the proposed NOMA-HDR or NOMA-FDR scheme with power adaption clearly outperforms the NOMA-HDR or NOMA-FDR scheme with fixed power allocation. Besides, when the residual self-interference channel gain is small, the performance of NOMA-FDR system is better than the NOMA-HDR system.
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| 6. |
- Wu, Chuanyan, et al.
(författare)
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PEPRF : Identification of Essential Proteins by Integrating Topological Features of PPI Network and Sequence-based Features via Random Forest
- 2021
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Ingår i: Current Bioinformatics. - : Bentham Science Publishers Ltd.. - 1574-8936. ; 16:9, s. 1161-1168
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Tidskriftsartikel (refereegranskat)abstract
- Background: Essential proteins play an important role in the process of life, which can be identified by experimental methods and computational approaches. Experimental approaches to identify essential proteins are of high accuracy but with the limitation of time and resource-consuming. Objective: Herein, we present a computational model (PEPRF) to identify essential proteins based on machine learning. Methods: Different features of proteins were extracted. Topological features of Protein-Protein Interaction (PPI) network-based are extracted. Based on the protein sequence, graph theory-based features, in-formation-based features, composition and physichemical features, etc., were extracted. Finally, 282 features are constructed. In order to select the features that contributed most to the identification, Re-liefF-based feature selection method was adopted to measure the weights of these features. Results: As a result, 212 features were curated to train random forest classifiers. Finally, PEPRF get the AUC of 0.71 and an accuracy of 0.742. Conclusion: Our results show that PEPRF may be applied as an efficient tool to identify essential pro-teins.
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| 7. |
- Yu, Chuanhe, et al.
(författare)
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A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
- 2018
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 361:6409, s. 1386-+-
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Tidskriftsartikel (refereegranskat)abstract
- How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Here we show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging strand preference increases markedly in cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, due to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading vs lagging strands, and that Dbp3-Dpb4 plays a significant role in this poorly understood process.
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| 8. |
- Yu, Chuanhe, et al.
(författare)
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Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall
- 2014
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Ingår i: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 56:4, s. 551-563
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Tidskriftsartikel (refereegranskat)abstract
- In eukaryotic cells, DNA replication proceeds with continuous synthesis of leading-strand DNA and discontinuous synthesis of lagging-strand DNA. Here we describe a method, eSPAN (enrichment and sequencing of protein-associated nascent DNA), which reveals the genome-wide association of proteins with leading and lagging strands of DNA replication forks. Using this approach in budding yeast, we confirm the strand specificities of DNA polymerases delta and epsilon and show that the PCNA clamp is enriched at lagging strands compared with leading-strand replication. Surprisingly, at stalled forks, PCNA is unloaded specifically from lagging strands. PCNA unloading depends on the Elg1-containing alternative RFC complex, ubiquitination of PCNA, and the checkpoint kinases Mec1 and Rad53. Cells deficient in PCNA unloading exhibit increased chromosome breaks. Our studies provide a tool for studying replication-related processes and reveal a mechanism whereby checkpoint kinases regulate strand-specific unloading of PCNA from stalled replication forks to maintain genome stability.
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| 9. |
- Zhao, Yaofeng, et al.
(författare)
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Ornithorhynchus anatinus (Platypus) Links the Evolution of Immunoglobulin Genes in Eutherian Mammals and Nonmammalian Tetrapods
- 2009
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 183:5, s. 3285-3293
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Tidskriftsartikel (refereegranskat)abstract
- The evolutionary origins of mammalian immunoglobulin H chain isotypes (IgM, IgD, IgG, IgE, and IgA) are still incompletely understood as these isotypes differ considerably in structure and number from their counterparts in nonmammalian tetrapods. We report in this study that the platypus (Ornithorhynchus anatinus) Ig H chain constant region gene locus contains eight Ig encoding genes, which are arranged in an mu-delta-o-gamma 2-gamma 1-alpha 1-epsilon-alpha 2 order, spanning a total of similar to 200 kb DNA, encoding six distinct isotypes. The o (o for Ornithorhynchus) gene encodes a novel Ig H chain isotype that consists of four constant region domains and a hinge, and is structurally different from any of the five known mammalian Ig classes. This gene is phylogenetically related to nu (epsilon) and gamma, and thus appears to be a structural intermediate between these two genes. The platypus delta gene encodes ten heavy chain constant region domains, lacks a hinge region and is similar to IgD in amphibians and fish, but strikingly different from that in eutherian mammals. The platypus Ig H chain isotype repertoire thus shows a unique combination of genes that share similarity both to those of nonmammallian tetrapods and eutherian animals and demonstrates how phylogenetically informative species can be used to reconstruct the evolutionary history of functionally important genes.
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| 10. |
- Zhou, Xue, et al.
(författare)
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Sensitive detection of oxygen using a diffused integrating cavity as a gas absorption cell
- 2017
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Ingår i: Sensors and Actuators B: Chemical. - : Elsevier BV. - 0925-4005. ; 241, s. 1076-1081
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Tidskriftsartikel (refereegranskat)abstract
- In this study, an oxygen monitoring system was demonstrated for sensitive oxygen detection. The system is based on tunable diode laser absorption spectroscopy (TDLAS) and wavelength modulation spectroscopy (WMS). Stable 2nd-harmonic signals of oxygen were detected by measuring the oxygen P9 absorption line at 764.38. nm. In the detection, a cubic diffuse integrating cavity was employed as a gas absorption cell to increase the optical path length and achieve a higher sensitivity. In addition, to perform automatic gas concentration measurements, a data recording and analyzing program based on the National Instruments LabVIEW software platform was developed. An uncertainty of 0.05% and a detection sensitivity of 350 ppmv were obtained using this system.
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