| 1. |
- Toshito, T., et al.
(författare)
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Measurements of projectile-like Be-8 and B-9 production in 200-400 MeV/nucleon C-12 on water
- 2008
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 78:6, s. 4-
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Tidskriftsartikel (refereegranskat)abstract
- We have studied the production of the projectile-like fragments Be-8 and B-9 produced in interactions of 200 to 400 MeV/nucleon carbon ions with water, using emulsion detectors. In this Brief Report we present the first published production cross section of the projectile-like fragment B-9 in the energy region above 100 MeV/nucleon. The measured production cross sections of these nuclides were compared to calculations using a semiempirical model. We found that the measured cross sections deviate from the calculated values by a factor up to about six. This information is of importance for benchmarking and improving heavy ion nuclear reaction models.
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| 2. |
- Toshito, T., et al.
(författare)
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Measurements of total and partial charge-changing cross sections for 200-to 400-MeV/nucleon C-12 on water and polycarbonate
- 2007
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 75:5, s. 8-
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Tidskriftsartikel (refereegranskat)abstract
- We have studied charged nuclear fragments produced by 200- to 400-MeV/nucleon carbon ions, interacting with water and polycarbonate, using a newly developed emulsion detector. Total and partial charge-changing cross sections for the production of B, Be, and Li fragments were measured and compared with both previously published measurements and model predictions. This study is of importance for validating and improving carbon-ion therapy treatment planning systems and for estimating the radiological risks for personnel on space missions, because carbon is a significant component of galactic cosmic rays.
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| 3. |
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| 4. |
- Kaemena, DF, et al.
(författare)
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B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors
- 2023
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 488-
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Tidskriftsartikel (refereegranskat)abstract
- Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout (KO) screening. Of these, depletion of the predicted KRAB zinc finger protein (KRAB-ZFP) Zfp266 strongly and consistently enhances murine iPSC generation in several reprogramming settings, emerging as the most robust roadblock. We show that ZFP266 binds Short Interspersed Nuclear Elements (SINEs) adjacent to binding sites of pioneering factors, OCT4 (POU5F1), SOX2, and KLF4, and impedes chromatin opening. Replacing the KRAB co-suppressor with co-activator domains converts ZFP266 from an inhibitor to a potent facilitator of iPSC reprogramming. We propose that the SINE-KRAB-ZFP interaction is a critical regulator of chromatin accessibility at regulatory elements required for efficient cellular identity changes. In addition, this work serves as a resource to further illuminate molecular mechanisms hindering reprogramming.
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