SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Zaczek A) "

Sökning: WFRF:(Zaczek A)

  • Resultat 1-10 av 14
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • In ’t Veld, Sjors G.J.G., et al. (författare)
  • Detection and localization of early- and late-stage cancers using platelet RNA
  • 2022
  • Ingår i: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 40:9, s. 999-1009.e6
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
  •  
2.
  •  
3.
  • Davidson, Iain F., et al. (författare)
  • Rapid movement and transcriptional re-localization of human cohesin on DNA
  • 2016
  • Ingår i: EMBO Journal. - : EMBO. - 0261-4189 .- 1460-2075. ; 35:24, s. 2671-2685
  • Tidskriftsartikel (refereegranskat)abstract
    • The spatial organization, correct expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring-shaped protein complexes that are thought to function by entrapping DNA. It has been proposed that cohesin is recruited to specific genomic locations from distal loading sites by an unknown mechanism, which depends on transcription, and it has been speculated that cohesin movements along DNA could create three-dimensional genomic organization by loop extrusion. However, whether cohesin can translocate along DNA is unknown. Here, we used single-molecule imaging to show that cohesin can diffuse rapidly on DNA in a manner consistent with topological entrapment and can pass over some DNA-bound proteins and nucleosomes but is constrained in its movement by transcription and DNA-bound CCCTC-binding factor (CTCF). These results indicate that cohesin can be positioned in the genome by moving along DNA, that transcription can provide directionality to these movements, that CTCF functions as a boundary element for moving cohesin, and they are consistent with the hypothesis that cohesin spatially organizes the genome via loop extrusion.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 14
Typ av publikation
tidskriftsartikel (12)
konferensbidrag (2)
Typ av innehåll
refereegranskat (12)
övrigt vetenskapligt/konstnärligt (2)
Författare/redaktör
Zetterstrom, C (10)
Griffioen, Arjan W. (1)
Olivestedt, G (1)
Verdonck-de Leeuw, I ... (1)
Teunissen, Charlotte ... (1)
Roos, Eva (1)
visa fler...
Cisneros, David A. (1)
Meijers-Heijboer, Ha ... (1)
Besselink, Marc G. (1)
Wurdinger, Thomas (1)
Tannous, Bakhos A (1)
Bahce, Idris (1)
Smit, Egbert F (1)
Lokhorst, Henk (1)
Laurell, CG (1)
Uhlmann, Frank (1)
Sol, Nik (1)
Ylstra, Bauke (1)
Dorsman, Josephine (1)
Reijneveld, Jaap C (1)
Wesseling, Pieter (1)
Best, Myron G. (1)
Tannous, Jihane (1)
Westerman, Bart A. (1)
Verschueren, Heleen (1)
Post, Edward (1)
Verheul, Henk M. (1)
Noske, David P. (1)
Nilsson, R. Jonas A. (1)
Vancura, Adrienne (1)
Muller, Mirte (1)
Niemeijer, Anna-Lari ... (1)
Tjon Kon Fat, Lee-An ... (1)
Meijer, Laura L. (1)
Wedekind, Laurine E. (1)
Kazemier, Geert (1)
Giovannetti, Elisa (1)
Idema, Sander (1)
Killestein, Joep (1)
Heger, Michal (1)
de Jager, Saskia C. (1)
Pasterkamp, Gerard (1)
Bogaard, Harm-Jan (1)
Vandertop, W. Peter (1)
van den Broek, Daan (1)
Lee-Lewandrowski, El ... (1)
Lewandrowski, Kent B ... (1)
de Langen, Adrianus ... (1)
van den Heuvel, Mich ... (1)
Hiltermann, T. Jeroe ... (1)
visa färre...
Lärosäte
Karolinska Institutet (12)
Umeå universitet (2)
Språk
Engelska (14)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy