| 1. |
- Gemo, Nicola, et al.
(författare)
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The influence of catalyst amount and Pd loading on the H2O2 synthesis from hydrogen and oxygen
- 2015
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Ingår i: Catalysis Science & Technology. - : Royal Society of Chemistry (RSC). - 2044-4753 .- 2044-4761. ; 5:7, s. 3545-3555
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Tidskriftsartikel (refereegranskat)abstract
- Palladium catalysts with an active metal content from 0.3 to 5.0 wt.% and supported on a strongly acidic, macroporous resin were prepared by ion-exchange/reduction method. H2O2 direct synthesis was carried out in the absence of promoters (acids and halides). The total Pd amount in the reacting environment was varied by changing A) the catalyst concentration in the slurry and B) the Pd content of the catalyst. In both cases, smaller amounts of the active metal enhance the selectivity towards H2O2, at any H-2 conversion, with option B) better than A). In case A), the Pd(II)/Pd(0) molar ratio (XPS) in the spent catalysts was found to decrease at lower catalyst Pd content. With these catalysts and this experimental set-up the dynamic H-2(1)/Pd molar ratio, the metal loading and the metal particle size were the key factors controlling the selectivity, which reached 57% at 60% H-2 conversion, and 80% at lower conversion.
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| 2. |
- Lankester, Arjan C, et al.
(författare)
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Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort.
- 2022
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Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 149:5
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Tidskriftsartikel (refereegranskat)abstract
- Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome.We performed a comprehensive multicenter analysis of genotype-specific HSCT outcome, including detailed analysis of immune reconstitution (IR) and the predictive value for clinical outcome.HSCT outcome was studied in 338 patients with genetically confirmed SCID who underwent transplantation in 2006-2014 and who were registered in the SCETIDE registry. In a representative subgroup of 152 patients, data on IR and long-term clinical outcome were analyzed.Two-year OS was similar with matched family and unrelated donors and better than mismatched donor HSCT (P<.001). The 2-year event-free survival (EFS) was similar in matched and mismatched unrelated donor and less favorable in mismatched related donor (MMRD) HSCT (P< .001). Genetic subgroups did not differ in 2-year OS (P= .1) and EFS (P=.073). In multivariate analysis, pretransplantation infections and use of MMRDs were associated with less favorable OS and EFS. With a median follow-up of 6.2 years (range, 2.0-11.8 years), 73 of 152 patients in the IR cohort were alive and well without Ig dependency. IL-2 receptor gamma chain/Janus kinase 3/IL-7 receptor-deficient SCID, myeloablative conditioning, matched donor HSCT, and naive CD4 T lymphocytes >0.5×10e3/μL at+1 year were identified as independent predictors of favorable clinical and immunologic outcome.Recent advances in HSCT in SCID patients have resulted in improved OS and EFS in all genotypes and donor types. To achieve a favorable long-term outcome, treatment strategies should aim for optimal naive CD4 T lymphocyte regeneration.
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| 3. |
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| 4. |
- Machowicz, Rafal, et al.
(författare)
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Allogeneic hematopoietic stem cell transplantation for adult HLH : a retrospective study by the chronic malignancies and inborn errors working parties of EBMT
- 2022
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Ingår i: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 57:5, s. 817-823
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Tidskriftsartikel (refereegranskat)abstract
- Hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) is a rare syndrome of potentially fatal, uncontrolled hyperinflammation. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is indicated in primary, recurrent or progressive HLH, but information about its outcomes in the adult population is limited. We obtained data about 87 adult (>= 18 years of age) patients retrospectively reported to the EBMT. The median survival time was 13.9 months. The three and five-year overall survival (OS) was 44% (95% CI 33-54%). Among 39 patients with a follow-up longer than 15 months, only three died. Relapse rate was 21% (95% CI 13-30%), while NRM reached 36% (95% CI 25-46%). Younger patients (<30 years of age) had better prognosis, with an OS of 59% (95% CI 45-73%) at three and five years vs 23% (95% CI 8-37%) for older ones. No difference in survival between reduced and myeloablative conditioning was found. To our knowledge, this is the largest report of adult HLH patients who underwent allo-HSCT. Patients who survive the first period after this procedure can expect a long disease-free survival. Both reduced intensity and myeloablative conditioning have therapeutic potential in adult HLH.
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| 5. |
- Oevermann, Lena, et al.
(författare)
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KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.
- 2014
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 124:17, s. 2744-2747
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Tidskriftsartikel (refereegranskat)abstract
- We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score.
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| 6. |
- Sandahl, Julie Damgaard, et al.
(författare)
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t(6;9)(p22; q34)/DEK-NUP214-rearranged pediatric myeloid leukemia : an international study of 62 patients
- 2014
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 99:5, s. 865-872
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Tidskriftsartikel (refereegranskat)abstract
- Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54 diagnosed as having acute myeloid leukemia, representing <1% of all childhood acute myeloid leukemia, and eight as having myelodysplastic syndrome. The t(6; 9)/DEK-NUP214 was associated with relatively late onset (median age 10.4 years), male predominance (sex ratio 1.7), French-American-British M2 classification (54%), myelodysplasia (100%), and FLT3-ITD (42%). Outcome was substantially better than previously reported with a 5-year event-free survival of 32%, 5-year overall survival of 53%, and a 5-year cumulative incidence of relapse of 57%. Hematopoietic stem cell transplantation in first complete remission improved the 5-year event-free survival compared with chemotherapy alone (68% versus 18%; P<0.01) but not the overall survival (68% versus 54%; P=0.48). The presence of FLT3-ITD had a non-significant negative effect on 5-year overall survival compared with non-mutated cases (22% versus 62%; P=0.13). Gene expression profiling showed a unique signature characterized by significantly higher expression of EYA3, SESN1, PRDM2/RIZ, and HIST2H4 genes. In conclusion, t(6; 9)/DEK-NUP214 represents a unique subtype of acute myeloid leukemia with a high risk of relapse, high frequency of FLT3-ITD, and a specific gene expression signature.
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| 7. |
- Sterchele, Stefano, et al.
(författare)
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Influence of Metal Precursors and Reduction Protocols on the Chloride-Free Preparation of Catalysts for the Direct Synthesis of Hydrogen Peroxide without Selectivity Enhancers
- 2016
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Ingår i: ChemCatChem. - : John Wiley & Sons. - 1867-3880 .- 1867-3899. ; 8:8, s. 1564-1574
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Tidskriftsartikel (refereegranskat)abstract
- Different metal precursors and reducing agents were applied in the preparation of 1 wt % Pd catalysts supported on commercial ion-exchange resin (Lewatit K2621) and used in the direct synthesis of H2O2. The catalysts were characterized by using TEM and their performance was evaluated in the direct synthesis of H2O2 (in a batch and semi-batch reactor) to investigate the relationship between the catalyst preparation methods, morphology, and catalytic performance. As expected, both the choice of the Pd precursor and the reduction conditions had a strong influence on the size and size distribution of the resulting supported nanostructured metal nanoparticles and, consequently, on the catalytic performance. The best combination of metal precursor and reduction agent was [Pd(NH3)4]SO4 reduced with hydrogen. This catalyst had the largest average size of the Pd nanoparticles and the broadest size distribution.
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| 8. |
- Sterchele, Stefano, et al.
(författare)
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The effect of the metal precursor-reduction with hydrogen on a library of bimetallic Pd-Au and Pd-Pt catalysts for the direct synthesis of H2O2
- 2015
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Ingår i: Catalysis Today. - : Elsevier. - 0920-5861 .- 1873-4308. ; 248, s. 40-47
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Tidskriftsartikel (refereegranskat)abstract
- Two sets of bimetallic Pd-Pt (Pd: 1.0; Pt: 0.25-1.0%, w/w) and Pd-Au (Pd: 1.0; Au: 0.25-1.0%, w/w) catalysts have been used, with no added promoter, in the catalytic direct synthesis (CDS) of hydrogen peroxide from its elements at 2 °C with a CO2/O2/H2 mixture (72/25.5/2.5%, respectively). The catalysts were supported on the commercial macroreticular ion-exchange resin Lewatit K2621 and were obtained from the reduction with H2 of ion-exchanged cationic precursors at 5 bar and at 60 °C. The addition of Pt or Au to Pd produced an increase of the initial overall catalytic activity in comparison with monometallic Pd with both the second metals, but with Pt the increase was much higher than with Au. Moreover, the addition of 0.25% (w/w) Pt, or more, invariably made all the Pd-Pt catalysts less selective with respect to Pd alone. In the case of Au, by contrast, the addition of 0.25% w/w produced an increase, albeit small, of the selectivity. As the result, the most active and productive Pd-Pt catalyst was 1Pd025PtK2621 with 1891 mol(H2) mo l(Pd + Pt) - 1 h- 1 initially consumed, 1875 mol(H2 O2) mo l(Pd + Pt) - 1 h- 1 initially produced, a 45% selectivity towards H2O2 at 50% conversion of H2. In the case of the Pd-Au bimetallic catalysts, 1Pd025AuK2621 was the best one, with 1184 mol(H2) mo l(Pd + Pt) - 1 h- 1 initially consumed, 739 mol(H2 O2) mo l(Pd + Pt) - 1 h- 1 initially produced, a 55% selectivity towards H2O2 at 50% conversion of H2. Although the characterization of the Pd-Pt and Pd-Au catalysts with TEM showed that the morphology of the nanostructured metal phases in the Pd-Pt and Pd-Au catalysts was very different from each family to the other, no clear correlation between the size of the nanoparticles and their distribution and the catalytic performance was apparent. These catalysts were also generally different, especially the Pd-Au ones, from previously reported related materials obtained from the same support and the same precursor, but with a different reducing agent (formaldehyde). © 2014 Elsevier B.V. All rights reserved.
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