| 1. |
- Gatera, A., et al.
(författare)
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Prompt-fission γ -ray spectral characteristics from Pu 239 (nth,f)
- 2017
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 95:6
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Tidskriftsartikel (refereegranskat)abstract
- In this paper we present new results for prompt fission γ-ray spectral characteristics from the thermal neutron induced fission of Pu∗240. The measured spectra were unfolded by using the detectors' response functions, simulated with geant4. We obtained in average per fission a γ-ray multiplicity Mγ=(7.35±0.12), a mean photon energy ϵγ=(0.85±0.02) MeV, and an average total energy released in fission Ēγ,tot=(6.27±0.11) MeV. Our results are in good agreement with historical data measured in the 1970s by Verbinski et al. and results from recent calculations in the framework of Monte Carlo Hauser-Feshbach models. Our measured average total energy is slightly smaller than the one deduced previously and present in evaluated data. From this we conclude that the Pu239(nth,f) reaction may be ruled out as possible source of γ heating underestimation, when compared with benchmark calculations based on existing nuclear data.
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| 2. |
- Zeiser, R., et al.
(författare)
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Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
- 2015
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 29:10, s. 2062-2068
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Tidskriftsartikel (refereegranskat)abstract
- Despite major improvements in allogeneic hematopoietic cell transplantation over the past decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease (GVHD) cause high mortality. Preclinical evidence indicates the potent anti-inflammatory properties of the JAK1/2 inhibitor ruxolitinib. In this retrospective survey, 19 stem cell transplant centers in Europe and the United States reported outcome data from 95 patients who had received ruxolitinib as salvage therapy for SR-GVHD. Patients were classified as having SR-aGVHD (n = 54, all grades III or IV) or SR-cGVHD (n = 41, all moderate or severe). The median number of previous GVHD-therapies was 3 for both SR-aGVHD (1-7) and SR-cGVHD (1-10). The overall response rate was 81.5% (44/54) in SR-aGVHD including 25 complete responses (46.3%), while for SR-cGVHD the ORR was 85.4% (35/41). Of those patients responding to ruxolitinib, the rate of GVHD-relapse was 6.8% (3/44) and 5.7% (2/35) for SR-aGVHD and SR-cGVHD, respectively. The 6-month-survival was 79% (67.3-90.7%, 95% confidence interval (CI)) and 97.4% (92.3-100%, 95% CI) for SR-aGVHD and SR-cGVHD, respectively. Cytopenia and cytomegalovirus-reactivation were observed during ruxolitinib treatment in both SR-aGVHD (30/54, 55.6% and 18/54, 33.3%) and SR-cGVHD (7/41, 17.1% and 6/41, 14.6%) patients. Ruxolitinib may constitute a promising new treatment option for SR-aGVHD and SR-cGVHD that should be validated in a prospective trial.
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| 6. |
- Qi, L., et al.
(författare)
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Potential of prompt γ -ray emission studies in fast-neutron induced fission : a first step
- 2020
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 56:3
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Tidskriftsartikel (refereegranskat)abstract
- Prompt γ-ray spectra emitted in fast-neutron induced fission of 239Pu have been recently measured by using the LICORNE directional neutron source at En = 1.8 MeV. The results are used in parallel with the measurements of fast-neutron induced fission of 238U and spontaneous fission of 252Cf to assess the potential of such reactions and observables, in contributing to the understanding of fission. The γ-ray spectra were measured and analyzed under similar conditions, allowing a consistent and robust comparison between the three systems. They are further compared to Monte–Carlo simulations based on two widely-used semi-empirical codes, FREYA and GEF. Differences in the low and high energy portions of the spectrum are interpreted based on simple arguments involving nuclear structure and evaporation effects. The significance and potential of experimental campaigns of this kind, as well as current limitations, are highlighted, together with straightforward but mandatory extensions.
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| 7. |
- Qi, L., et al.
(författare)
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Prompt fission gamma-ray emission spectral data for Pu-239(n,f) using fast directional neutrons from the LICORNE neutron source
- 2018
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Ingår i: SCIENTIFIC WORKSHOP ON NUCLEAR FISSION DYNAMICS AND THE EMISSION OF PROMPT NEUTRONS AND GAMMA RAYS (THEORY-4). - : EDP Sciences. - 9782759890316
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Konferensbidrag (refereegranskat)abstract
- Prompt fission gamma-ray spectra (PFGS) have been measured for the Pu-239(n,f) reaction using fast neutrons at E-n =1.81 MeV produced by the LICORNE directional neutron source. The setup makes use of LaBr3 scintillation detectors and PARIS phoswich detectors to measure the emitted prompt fission gamma rays (PFG). The mean multiplicity, average total energy release per fission and average energy of photons are extracted from the unfolded PFGS. These new measurements provide complementary information to other recent work on thermal neutron induced fission of Pu-239 and spontaneous fission of Cf-252.
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