| 1. |
- Getahun, H, et al.
(author)
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Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries
- 2015
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 46:6, s. 1563-1576
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Journal article (peer-reviewed)abstract
- Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosis (TB). Here we report evidence-based guidelines from the World Health Organization for a public health approach to the management of LTBI in high risk individuals in countries with high or middle upper income and TB incidence of <100 per 100 000 per year. The guidelines strongly recommend systematic testing and treatment of LTBI in people living with HIV, adult and child contacts of pulmonary TB cases, patients initiating anti-tumour necrosis factor treatment, patients receiving dialysis, patients preparing for organ or haematological transplantation, and patients with silicosis. In prisoners, healthcare workers, immigrants from high TB burden countries, homeless persons and illicit drug users, systematic testing and treatment of LTBI is conditionally recommended, according to TB epidemiology and resource availability. Either commercial interferon-gamma release assays or Mantoux tuberculin skin testing could be used to test for LTBI. Chest radiography should be performed before LTBI treatment to rule out active TB disease. Recommended treatment regimens for LTBI include: 6 or 9 month isoniazid; 12 week rifapentine plus isoniazid; 3–4 month isoniazid plus rifampicin; or 3–4 month rifampicin alone.
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| 2. |
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| 3. |
- Lembrechts, Jonas J., et al.
(author)
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SoilTemp : A global database of near-surface temperature
- 2020
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In: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 26:11, s. 6616-6629
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Journal article (peer-reviewed)abstract
- Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long-term average thermal conditions at coarse spatial resolutions only. Hence, many climate-forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to effects of observation height (e.g. vegetation, snow and soil characteristics) and in habitats varying in their exposure to radiation, moisture and wind (e.g. topography, radiative forcing or cold-air pooling). Since organisms living close to the ground relate more strongly to these microclimatic conditions than to free-air temperatures, microclimatic ground and near-surface data are needed to provide realistic forecasts of the fate of such organisms under anthropogenic climate change, as well as of the functioning of the ecosystems they live in. To fill this critical gap, we highlight a call for temperature time series submissions to SoilTemp, a geospatial database initiative compiling soil and near-surface temperature data from all over the world. Currently, this database contains time series from 7,538 temperature sensors from 51 countries across all key biomes. The database will pave the way toward an improved global understanding of microclimate and bridge the gap between the available climate data and the climate at fine spatiotemporal resolutions relevant to most organisms and ecosystem processes.
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| 4. |
- Lonnroth, K, et al.
(author)
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Towards tuberculosis elimination: an action framework for low-incidence countries
- 2015
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 45:4, s. 928-952
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Journal article (peer-reviewed)abstract
- This paper describes an action framework for countries with low tuberculosis (TB) incidence (<100 TB cases per million population) that are striving for TB elimination. The framework sets out priority interventions required for these countries to progress first towards “pre-elimination” (<10 cases per million) and eventually the elimination of TB as a public health problem (less than one case per million). TB epidemiology in most low-incidence countries is characterised by a low rate of transmission in the general population, occasional outbreaks, a majority of TB cases generated from progression of latent TB infection (LTBI) rather than local transmission, concentration to certain vulnerable and hard-to-reach risk groups, and challenges posed by cross-border migration. Common health system challenges are that political commitment, funding, clinical expertise and general awareness of TB diminishes as TB incidence falls. The framework presents a tailored response to these challenges, grouped into eight priority action areas: 1) ensure political commitment, funding and stewardship for planning and essential services; 2) address the most vulnerable and hard-to-reach groups; 3) address special needs of migrants and cross-border issues; 4) undertake screening for active TB and LTBI in TB contacts and selected high-risk groups, and provide appropriate treatment; 5) optimise the prevention and care of drug-resistant TB; 6) ensure continued surveillance, programme monitoring and evaluation and case-based data management; 7) invest in research and new tools; and 8) support global TB prevention, care and control. The overall approach needs to be multisectorial, focusing on equitable access to high-quality diagnosis and care, and on addressing the social determinants of TB. Because of increasing globalisation and population mobility, the response needs to have both national and global dimensions.
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| 6. |
- Andric, M., et al.
(author)
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Parental divorce in early life and entrepreneurial performance in adulthood
- 2024
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In: Journal of Business Venturing. - : Elsevier. - 0883-9026 .- 1873-2003. ; 39:3
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Journal article (peer-reviewed)abstract
- We examine how parental divorce in early life affects performance in entrepreneurship in adulthood. Drawing on life course theory and empirical analyses of US self-employment and childhood data from the National Longitudinal Survey of Youth 1979, we show that entrepreneurs' experience of parental divorce in childhood benefits their entrepreneurial performance in adulthood through a gain in self-efficacy while simultaneously suppressing entrepreneurial performance through a shortfall in human capital. We also show that whether the performance advantages or disadvantages from parental divorce dominate depends on parental human capital. While parental divorce is associated with underperformance for entrepreneurs whose parents have high levels of human capital, it is positively related to entrepreneurial performance for those with low parental human capital. Our study contributes new theory and evidence on the intertemporal relationship between past family contexts and present entrepreneurial performance.
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| 7. |
- Andric, M., et al.
(author)
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SOCIO-HISTORICAL SHIFTS IN LIFE STAGE AT ENTREPRENEURIAL ENTRY AND THEIR PERFORMANCE IMPLICATIONS
- 2022
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In: Academy of Management Proceedings. - : Academy of Management.
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Conference paper (peer-reviewed)abstract
- Drawing on life course theory, we propose that shifting age norms have resulted in individuals today being younger, less experienced, and more frequently unmarried and childless at the time of entering entrepreneurship than in the past. We conjecture that these socio-historical shifts in life stage at entrepreneurial entry bear largely negative implications for entrepreneurial performance. Moreover, we argue for gender differences in the effect of parenthood on entrepreneurial performance, which we suggest have decreased over time due to the decline of traditional gender roles. Cohort analyses of data from the U.S. National Longitudinal Surveys of Youth support our conjectures.
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