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Träfflista för sökning "WFRF:(Zhang Claire X.) "

Search: WFRF:(Zhang Claire X.)

  • Result 1-7 of 7
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1.
  • 2019
  • Journal article (peer-reviewed)
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2.
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3.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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4.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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5.
  • Thomas, HS, et al. (author)
  • 2019
  • swepub:Mat__t
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6.
  • Hiam, Lucinda, et al. (author)
  • What can the UK learn from the impact of grant populations on national life expectancy?
  • 2022
  • In: Journal of Public Health. - : Oxford University Press (OUP). - 1741-3842 .- 1741-3850. ; 44:4, s. e499-e505
  • Journal article (peer-reviewed)abstract
    • Improvements in life expectancy at birth in the UK had stalled prior to 2020 and have fallen during the COVID-19 pandemic. The stagnation took place at a time of relatively high net migration, yet we know that migrants to Australia, the USA and some Nordic countries have positively impacted national life expectancy trends, outperforming native-born populations in terms of life expectancy. It is important to ascertain whether migrants have contributed positively to life expectancy in the UK, concealing worsening trends in the UK-born population, or whether relying on national life expectancy calculations alone may have masked excess mortality in migrant populations. We need a better understanding of the role and contribution of migrant populations to national life expectancy trends in the UK.
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7.
  • van der Harst, Pim, et al. (author)
  • Seventy-five genetic loci influencing the human red blood cell
  • 2012
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 492:7429, s. 369-375
  • Journal article (peer-reviewed)abstract
    • Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
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  • Result 1-7 of 7

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