| 1. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 2. |
- Liu, Yanrong, et al.
(författare)
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Ionic liquids/deep eutectic solvents for CO2 capture: Reviewing and evaluating
- 2021
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Ingår i: Green Energy & Environment. - : Elsevier. - 2468-0257. ; 6:3, s. 314-328
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Tidskriftsartikel (refereegranskat)abstract
- The CO2 solubilities (including CO2 Henry’s constant) in physical- and chemical-based ILs/DESs and the COSMO-RS models describing these properties were comprehensively collected and summarized. The summarized results indicate that chemical-based ILs/DESs are superior to physical-based ILs/DESs for CO2 capture, especially those ILs have functionalized cation and anion, and superbase DESs; some of the superbase DESs have higher CO2 solubilities than those of ILs; the best physical- and chemical-based ILs, as well as physical- and chemical-based DESs are [BMIM][BF4] (4.20 mol kg-1), [DETAH][Im] (11.91 mol kg-1), [L-Arg]-Gly 1:6 (4.92 mol kg-1) and TBD-EG 1:4 (12.90 mol kg-1), respectively. Besides the original COSMO-RS mainly providing qualitative predictions, six corrected COSMO-RS models have been proposed to improve the prediction performance based on the experimental data, but only one model is with universal parameters. The newly determined experimental results were further used to verify the perditions of original and corrected COSMO-RS models. The comparison indicates that the original COSMO-RS qualitatively predicts CO2 solubility for some but not all ILs/DESs, while the quantitative prediction is incapable at all. The original COSMO-RS is capable to predict CO2 Henry’s constant qualitatively for both physical-based ILs and DESs, and quantitative prediction is only available for DESs. For the corrected COSMO-RS models, only the model with universal parameters provides quantitative predictions for CO2 solubility in physical-based DESs, while other corrected models always show large deviations (>83%) compared with the experimental CO2 Henry’s constants.
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| 3. |
- Yuan, Jun, et al.
(författare)
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Understanding energetic disorder in electron-deficient-core-based non-fullerene solar cells
- 2020
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Ingår i: Science in China Series B. - : SCIENCE PRESS. - 1674-7291 .- 1869-1870. ; 63:8, s. 1159-1168
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Tidskriftsartikel (refereegranskat)abstract
- Recent advances in material design for organic solar cells (OSCs) are primarily focused on developing near-infrared non-fullerene acceptors, typically A-DA D-A type acceptors (where A abbreviates an electron-withdrawing moiety and D, an electron-donor moiety), to achieve high external quantum efficiency while maintaining low voltage loss. However, the charge transport is still constrained by unfavorable molecular conformations, resulting in high energetic disorder and limiting the device performance. Here, a facile design strategy is reported by introducing the "wing" (alkyl chains) at the terminal of the DA D central core of the A-DA D-A type acceptor to achieve a favorable and ordered molecular orientation and therefore facilitate charge carrier transport. Benefitting from the reduced disorder, the electron mobilities could be significantly enhanced for the "wing"-containing molecules. By carefully changing the length of alkyl chains, the mobility of acceptor has been tuned to match with that of donor, leading to a minimized charge imbalance factor and a high fill factor (FF). We further provide useful design strategies for highly efficient OSCs with high FF.
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| 4. |
- Zhang, Zhibo, et al.
(författare)
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Zinc-based deep eutectic solvent – An efficient carbonic anhydrase mimic for CO2 hydration and conversion
- 2021
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Ingår i: Separation and Purification Technology. - : Elsevier. - 1383-5866 .- 1873-3794. ; 276
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Tidskriftsartikel (refereegranskat)abstract
- Carbonic anhydrase (CA) has demonstrated great potential to mitigate CO2 emissions by enzymatic conversion of CO2, while its commercial implementation is limited by the inherent shortcomings of CA, such as thermal and chemical instability, high sensitivity to the environment, and high cost. To overcome the drawbacks of CA and develop advanced technologies for mitigating CO2 emission, for the first time, mimetic CA (ZnHisGly) with the characteristics of natural CA was designed and synthesized, i.e., zinc-based deep eutectic solvent (DES), to boost CO2 hydration and conversion. The mimetic CA exhibited facile synthesis, high stability, and low cost as the characteristics of DES, and showed better catalytic performance compared to the currently reported mimetic CA. Particularly, its catalytic performance increased greatly with increasing pH and temperatures, which provides promising prospects in the industrial applications of DES-based CA mimics.
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| 5. |
- Li, Jiajia, et al.
(författare)
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Recent Applications of Ionic Liquids in Quasi-Solid-State Lithium Metal Batteries
- 2021
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Ingår i: Green Chemical Engineering. - : Elsevier. - 2666-9528. ; 2:3, s. 253-265
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Forskningsöversikt (refereegranskat)abstract
- Quasi-solid-state lithium metal batteries are considered as one of the most promising energy storage devices, and the application of ionic liquids (ILs) as a new generation of functionalized electrolyte components in lithium metal batteries has become one of the research focuses. In this review, the very recent research work related to using IL to develop quasi-solid-state electrolytes and their influences on the performances of quasi-solid-state lithium metal batteries were surveyed and summarized, suggesting that the introduction of ILs can improve the ionic conductivity, broaden the electrochemical stability window, and enhance the electrochemical stability of selected electrolytes. Moreover, using ILs to prepare high-performance electrodes with unique microstructures and uniform distribution of fillers were also introduced. The composite quasi-solid-state electrolytes were suggested as the mainstream of electrolytes in the future due to the combination of the advantages of inorganic and polymer quasi-solid-state electrolytes, and their development challenges in high energy and high safety quasi-solid-state lithium metal batteries were also discussed.
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| 6. |
- Liu, Huan, et al.
(författare)
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The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway
- 2022
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Ingår i: The FEBS Journal. - : John Wiley & Sons. - 1742-464X .- 1742-4658. ; 289:1, s. 279-293
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Kashin-Beck disease (KBD) is an endemic osteochondropathy. Due to a lack of suitable animal or cellular disease models, the research progress on KBD has been limited. Our goal was to establish the first disease-specific human induced pluripotent stem cells (hiPSCs) cellular disease model of KBD, and to explore its etiology and pathogenesis exploiting transcriptome sequencing.METHODS: HiPSCs were reprogrammed from dermal fibroblasts of two KBD and one healthy control donors via integration-free vectors. Subsequently, hiPSCs were differentiated into chondrocytes through three-week culture. Gene expression profiles in KBD, normal primary chondrocytes and hiPSC-derived chondrocytes were defined by RNA sequencing. A Venn diagram was constructed to show the number of shared differentially expressed genes (DEGs) between KBD and normal. Gene oncology and Kyoto Encyclopedia of Genes and Genomes annotations were performed, and six DEGs were further validated in other individuals by real-time quantitative reverse transcription PCR (RT-qPCR).RESULTS: KBD cellular disease models were successfully established by generation of hiPSC lines. Seventeen consistent and significant DEGs present in all compared groups (KBD and normal) were identified. RT-qPCR validation gave consistent results with the sequencing data. Glycosaminoglycan biosynthesis-heparan sulfate/heparin, PPAR signaling pathway and cell adhesion molecules (CAMs) pathways were identified to be significantly altered in KBD.CONCLUSION: Differentiated chondrocytes deriving from KBD-origin hiPSCs provide the first cellular disease model for etiological studies of KBD. This study also provides new sights into the pathogenesis and etiology of KBD and is likely to inform the development of targeted therapeutics for its treatment.
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| 7. |
- Song, Jiage, et al.
(författare)
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Over 13% Efficient Organic Solar Cells Based on Low-Cost Pentacyclic A-DA D-A-Type Nonfullerene Acceptor
- 2021
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Ingår i: Solar RRL. - : Wiley-Blackwell. - 2367-198X. ; 5:8
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Tidskriftsartikel (refereegranskat)abstract
- Recent studies have almost focused on finding active layer materials with extended pi-conjugation structures for high-performance organic solar cells (OSCs). However, with the extension of conjugate length, the synthesis difficulty and cost of materials will increase. Achieving high efficiency while reducing material costs is a prerequisite for the commercialization of OSCs. Herein, two low-cost A-DA D-A-type (where A and D represent an electron-withdrawing unit and an electron-donating unit, respectively) nonfullerene acceptors (Y25,Y26) are synthesized with pentacyclic fused backbone as the DA D electron-deficient core and 5,6-difluoro-3-(dicyandiamethyl) indigo as the end groups. Compared with classical Y series acceptors with heptacyclic backbone, although Y25 and Y26 own the reduced conjugated length, they still show moderate performance (11.65% and 13.34%), and the cost of synthesis is significantly reduced. Therefore, we provide a new molecular design idea for commercially efficient nonfullerene OSCs acceptors. We also find that adding alkyl chains to the beta site of thiophenes is beneficial to obtaining the reduced energetic disorder, dominant molecular stacking, and desirable morphology, which can facilitate charge carrier transport and prompt higher short-circuit current density (J(sc)) as well as fill factor.
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| 8. |
- Zhang, Sheng, et al.
(författare)
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Full review : The progress and developing trends of nanosheet-based sensing applications
- 2021
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Ingår i: Coordination chemistry reviews. - : Elsevier BV. - 0010-8545 .- 1873-3840. ; 433, s. 213742-213742
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Tidskriftsartikel (refereegranskat)abstract
- Due to the extremely high area-to-thickness, nanosheets have become one of the rising research fields with vast applications. In comparison with other bulk materials, the 2D structure reveals unique physical (e.g., ultra-thin thickness, high flexibility and stretchability, excellent adhesion, etc.), electrochemical properties (e.g., superior electrical, catalytic properties, etc.) and expected to have immense potential for high-performance sensors. In this review, the state-of-the-art research in nanosheet-based sensing applications are discussed into three subtopics of the electrocatalytic sensor, gas sensor and epidermal sensor.
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| 9. |
- Zhang, Yanan, et al.
(författare)
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Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents
- 2021
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Ingår i: BMC Musculoskeletal Disorders. - : BioMed Central. - 1471-2474. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners. However, it is still unclear which clinical features of KBD are more informative for the diagnosis of Kashin-Beck disease among adolescent.METHODS: We first manually extracted 26 possible features including clinical manifestations, and pathological changes of X-ray images from 400 KBD and 400 non-KBD adolescents. With such features, we performed four classification methods, i.e., random forest algorithms (RFA), artificial neural networks (ANNs), support vector machines (SVMs) and linear regression (LR) with four feature selection methods, i.e., RFA, minimum redundancy maximum relevance (mRMR), support vector machine recursive feature elimination (SVM-RFE) and Relief. The performance of diagnosis of KBD with respect to different classification models were evaluated by sensitivity, specificity, accuracy, and the area under the receiver operating characteristic (ROC) curve (AUC).RESULTS: Our results demonstrated that the 10 out of 26 discriminative features were displayed more powerful performance, regardless of the chosen of classification models and feature selection methods. These ten discriminative features were distal end of phalanges alterations, metaphysis alterations and carpals alterations and clinical manifestations of ankle joint movement limitation, enlarged finger joints, flexion of the distal part of fingers, elbow joint movement limitation, squatting limitation, deformed finger joints, wrist joint movement limitation.CONCLUSIONS: The selected ten discriminative features could provide a fast, effective diagnostic standard for KBD adolescents.
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| 10. |
- Zhang, Zhibo, et al.
(författare)
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Application and Challenge of Ionic Liquids as Co-solvent for Electro-enzymatic Conversion of CO2 to Methanol
- 2021
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Ingår i: Proceedings of the Chinese Society of Electrical Engineering. - : Chinese Society for Electrical Engineering. - 0258-8013. ; 41:11, s. 3657-3665
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Tidskriftsartikel (refereegranskat)abstract
- Utilization of carbon dioxide (CO2) has attracted great research interests, because CO2 is both a typical greenhouse gas and renewable carbon resource. This review mainly summarized and reviewed the research work linked to the challenges in the enzymatic conversion of CO2, such as NADH regeneration and low CO2 conversion efficiency. Based on the summary on the electro-enzymatic conversion of CO2, ionic liquids for the enzymatic conversion of CO2, and ionic liquids for the electrochemical conversion of CO2, we suggested applying ionic liquids as co-solvent in the enzymatic conversion of CO2 to methanol and coupling it with the reduction of NAD+ to NADH by electrocatalysis, providing a novel pathway for producing methanol from CO2.
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