SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Zhang Hanbin) "

Sökning: WFRF:(Zhang Hanbin)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hudson, Lawrence N, et al. (författare)
  • The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
  • 2017
  • Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
  • Tidskriftsartikel (refereegranskat)abstract
    • The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
  •  
2.
  • Yang, Fangkun, et al. (författare)
  • Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
  • 2023
  • Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 21:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundWe aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD).MethodsSummary-level genome-wide association statistics of CAD were obtained from the CARDIoGRAMplusC4D consortium (60,801 cases and 123,504 controls) and the FinnGen study (R8, 39,036 cases and 303,463 controls). Proteome-wide Mendelian randomization (MR) analysis was conducted to identify CAD-associated blood proteins, supplemented by colocalization analysis to minimize potential bias caused by linkage disequilibrium. Two-sample MR analyses were performed to assess the associations of genetically predicted four obesity measures and 13 lifestyle factors with CAD risk and CAD-associated proteins' levels. A two-step network MR analysis was conducted to explore the mediating effects of proteins in the associations between these modifiable factors and CAD.ResultsGenetically predicted levels of 41 circulating proteins were associated with CAD, and 17 of them were supported by medium to high colocalization evidence. PTK7 (protein tyrosine kinase-7), RGMB (repulsive guidance molecule BMP co-receptor B), TAGLN2 (transgelin-2), TIMP3 (tissue inhibitor of metalloproteinases 3), and VIM (vimentin) were identified as promising therapeutic targets. Several proteins were found to mediate the associations between some modifiable factors and CAD, with PCSK9, C1S, AGER (advanced glycosylation end product-specific receptor), and MST1 (mammalian Ste20-like kinase 1) exhibiting highest frequency among the mediating networks.ConclusionsThis study suggests pathways explaining the associations of obesity and lifestyle factors with CAD from alterations in blood protein levels. These insights may be used to prioritize therapeutic intervention for further study.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Hylander, Kristoffer (1)
Granjon, Laurent (1)
Abrahamczyk, Stefan (1)
Jonsell, Mats (1)
Brunet, Jörg (1)
Kolb, Annette (1)
visa fler...
Sáfián, Szabolcs (1)
Larsson, Susanna C. (1)
Persson, Anna S. (1)
Franzén, Markus (1)
Jung, Martin (1)
Nilsson, Sven G (1)
Berg, Åke (1)
Entling, Martin H. (1)
Goulson, Dave (1)
Herzog, Felix (1)
Knop, Eva (1)
Tscharntke, Teja (1)
Aizen, Marcelo A. (1)
Petanidou, Theodora (1)
Stout, Jane C. (1)
Woodcock, Ben A. (1)
Poveda, Katja (1)
Alignier, Audrey (1)
Batáry, Péter (1)
Krauss, Jochen (1)
Steffan-Dewenter, In ... (1)
Westphal, Catrin (1)
Wolters, Volkmar (1)
Edenius, Lars (1)
Rader, Romina (1)
Medina, Nagore G. (1)
Baeten, Lander (1)
Zhang, Han (1)
Dynesius, Mats (1)
de Sassi, Claudio (1)
Li, Xue (1)
Luskin, Matthew S. (1)
Slade, Eleanor M. (1)
Mikusinski, Grzegorz (1)
Gilbert, Benjamin (1)
Felton, Annika (1)
Samnegård, Ulrika (1)
Barlow, Jos (1)
Ficetola, Gentile F. (1)
Yu, Douglas W. (1)
Schweiger, Oliver (1)
Sadler, Jonathan P. (1)
Stefanescu, Constant ... (1)
Måren, Inger E. (1)
visa färre...
Lärosäte
Umeå universitet (1)
Uppsala universitet (1)
Stockholms universitet (1)
Lunds universitet (1)
Linnéuniversitetet (1)
Karolinska Institutet (1)
visa fler...
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy