| 1. |
|
|
| 2. |
- Yu, Han, et al.
(författare)
-
Study of the kinetics, mechanisms and catalysis activity of photo-electro degradation of organic pollutants via new neural network based methodology
- 2023
-
Ingår i: Applied Catalysis B: Environmental. - : Elsevier BV. - 0926-3373. ; 323
-
Tidskriftsartikel (refereegranskat)abstract
- A novel calculation methodology containing modeling and statistics was developed to assist the experimental process for the investigation of organics treatment process. A continuous-flow photo-electro treatment of Norfloxacin (NOR) was chosen as a target subject. The methodology is based on a new synergistic work of reaction energy calculation, full-scanned neural network (NN) simulation and new physical kinetics modeling. Degradation kinetics, mechanisms and activity of degradation catalyst, etc., were studied. As a result, the reaction energy calculation figured out eight potential degradation pathways of NOR with the corresponding intermediate. NN process with fully scanned parameters showed dominating advantage compared to non-linear regression and first-order law in simulation work. With the obtained database from NN, the new physical model successfully distributed degradation contribution into direct, indirect and water flow routes. The new methodology helped to gain more valuable information with less experimental work, which guided the efficient and greener investigation process in corresponding studies.
|
|
| 3. |
- Ding, Huaiyi, et al.
(författare)
-
Maximizing Integrated Optical and Electrical Properties of a Single ZnO Nanowire through Native Interfacial Doping
- 2014
-
Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 26:19, s. 3035-3041
-
Tidskriftsartikel (refereegranskat)abstract
- A native interfacial doping layer introduced in core-shell type ZnO nanowires by a simple vapor phase re-growth procedure endows the produced nanowires with both excellent electrical and optical performances compared to conventional homogeneous ZnO nanowires. The unique Zn-rich interfacial structure in the core-shell nanowires plays a crucial role in the outstanding performances.
|
|
| 4. |
- Sampson, Joshua N., et al.
(författare)
-
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- 2015
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
|
|
| 5. |
- Wang, Zhaoming, et al.
(författare)
-
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
-
Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
|
|
| 6. |
- Xue, Ru, et al.
(författare)
-
Variations of methane fluxes and methane microbial community composition with soil depth in the riparian buffer zone of a sponge city park
- 2023
-
Ingår i: Journal of Environmental Management. - : Elsevier. - 0301-4797 .- 1095-8630. ; 339
-
Tidskriftsartikel (refereegranskat)abstract
- Riparian buffers benefit both natural and man-made ecosystems by preventing soil erosion, retaining soil nu-trients, and filtering pollutants. Nevertheless, the relationship between vertical methane fluxes, soil carbon, and methane microbial communities in riparian buffers remains unclear. This study examined vertical methane fluxes, soil carbon, and methane microbial communities in three different soil depths (0-5 cm, 5-10 cm, and 10-15 cm) within a riparian buffer of a Sponge City Park for one year. Structural equation model (SEM) results demonstrated that vertical methane fluxes varied with soil depths (lambda =-0.37) and were primarily regulated by methanogenic community structure (lambda = 0.78). Notably, mathematical regression results proposed that mcrA/ pmoA ratio (R2 = 0.8) and methanogenic alpha diversity/methanotrophic alpha diversity ratio (R2 = 0.8) could serve as valid predictors of vertical variation in methane fluxes in the riparian buffer of urban river. These findings suggest that vertical variation of methane fluxes in riparian buffer soils is mainly influenced by carbon inputs and methane microbial abundance and community diversity. The study's results quantitatively the relationship between methane fluxes in riparian buffer soils and abiotic and biotic factors in the vertical di-rection, therefore contributing to the further development of mathematical models of soil methane emissions.
|
|
| 7. |
- Yu, Han, et al.
(författare)
-
Degradation of Norfloxacin in saline water by synergistic effect of anode and cathode in a novel photo-electrochemical system
- 2020
-
Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 242
-
Tidskriftsartikel (refereegranskat)abstract
- The removal and degradation of refractory antibiotics in saline water by electrochemical and photo-electrochemical catalysis has emerged as a worldwide research hotspot. Aiming to improve degradation performance, most of the concerned studies focus on new sophisticated materials and modification methods on the single working electrode (anode or cathode). But the synergistic effects between anode and cathode has rarely been studied, especially in photo-electrochemical system. In this work, these effects were initially developed and investigated in the photo-electrochemical system. In this work, a low-cost double-working electrodes photo-electrochemical system (TSSC-Photo) with Ti/SnO2-Sb anode and carbon black air diffusion cathode (TSSC) was constructed for Norfloxacin (NOR) degradation in saline water. The degradation efficiency, vital factors, degradation pathways were investigated. The mathematic modeling was adopted to distinguish the degradation kinetics and degradation contributions ratio from anode and cathode sides of this system. Owing to the synergistic effects of both electrodes, a rapidly complete NOR removal was achieved within 4 min and the highest TOC removal ratio reached 83.9% within 120 min. Free radicals (•Cl, •OH, etc) were considered as dominate oxidants in degradation with no activated chlorine (HClO/ClO−) detected from the electrolyte during the photo-electrolysis. The analysis based on the mathematic modeling indicated that anode acted as the only contributor (>97% of overall contribution) during the first 5 min of photo-electrolysis, whereas at the end of 120 min running, 21.4% of the total contribution came from cathode side. The remarkable performance of TSSC-Photo claimed its great capacity for organic matter degradation in saline water especially with Cl−.
|
|
| 8. |
- Yu, Han, et al.
(författare)
-
Improved Norfloxacin degradation by urea precipitation Ti/SnO2–Sb anode under photo-electro catalysis and kinetics investigation by BP-neural-network-physical modeling
- 2021
-
Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 280
-
Tidskriftsartikel (refereegranskat)abstract
- The photo-electro catalysis has emerged as efficient and sustainable degradation method for antibiotics, where metal oxide anode plays a critical role. Exploring novel preparation method for anodes catalysis to achieve larger active sites and diverse oxidants production can directly enhance the degradation performance. Therefore, in this work, a new urea precipitation method for anode formation was studied. Both novel urea precipitation Ti/SnO2–Sb anode (TSSA-U) and traditional electro-deposition Ti/SnO2–Sb anode (TSSA-E) were prepared for Norfloxacin degradation by photo-electro catalysis in saline water. A unique tubular Ti/SnO2–Sb units formatted by urea precipitation resulted in higher porosity. This led to dominating advantage for TSSA-U on photo/electrochemical activity and degradation performances by individual photo/electro catalysis, compared to TSSA-E. However, this gap of degradation performances shrank when synergistic effect of photo-electro catalysis involved. The highest TOC removal ratio of 91.1% was obtained from TSSA-U under photo-electro catalysis. Besides, a novel BP-neural-network-physical modeling (BP-ANN-P) was developed for analysis. According to this modeling, both direct (adsorption-degradation, radiation, etc.) and indirect (mainly •Cl) routes contributed significantly in degradation work by TSSA-U, where indirect route shared 41.8–90.1% of total degradation ratio. An increasing of current density (from 5 to 25 mA cm−2) enhanced the kinetics for both routes. Indirect route preferred pH = 3–7 with direct route enhanced by neutral condition. Moreover, indirect route also showed better adaptability with higher initial NOR loadings. Both urea precipitation and BP-ANN-P have shown their value for high performance material formation and data analysis, respectively. Notably, higher catalysis performance and better analysis connect to low energy cost, shorter running time and more efficient judgement and selection, which meets the requirement of cleaner production and environmental sustainability.
|
|
| 9. |
- Yu, Han, et al.
(författare)
-
Norfloxacin degradation by a green carbon black-Ti/SnO2-Sb electrochemical system in saline water
- 2019
-
Ingår i: Catalysis Today. - : Elsevier BV. - 0920-5861. ; 327, s. 308-314
-
Tidskriftsartikel (refereegranskat)abstract
- This work aims to degrade a typical antibiotic Norfloxacin (NOR) in saline water with a novel green carbon black based Ti/SnO2-Sb electrochemical catalysis system (TSSC), with Ti/SnO2-Sb as anode (TSSA) and a novel carbon black air diffusion electrode as cathode (CBAC). An electrochemical system with TSSA and a platinum carbon (Pt/C) cathode was used as control (TSSP). The removal ratio, degradation condition and the biodegradability were evaluated, the degradation pathway and mechanism were investigated. The result showed an efficient removal performance in both TSSC and TSSP systems. The removal ratio dropped with the lower current densities and higher initial pollutant loading. A considerable better removal performance was found in TSSC system, compared to that in TSSP system, when the low current density and saline concentration were applied. Meanwhile, 25.7% and 23.0% of COD removal ratios were obtained in TSSP and TSSC systems, respectively, in a short reaction time (25 min) and a very slight current density (0.18 mA cm−2). However, the TSSC showed a much more significant improvement of NOR biodegradability than that in TSSP system, indicating a considerable potential of TSSC system for both individual application and synergistic working with traditional biodegradation system for refractory antibiotics treatment.
|
|
| 10. |
- Yu, Han, et al.
(författare)
-
Study of SARS-CoV-2 transmission in urban environment by questionnaire and modeling for sustainable risk control
- 2021
-
Ingår i: Journal of Hazardous Materials. - : Elsevier BV. - 0304-3894. ; 420
-
Tidskriftsartikel (refereegranskat)abstract
- Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable epidemic and environmental transmission risk control (SEERC) in urban area is urgently needed. This work aims to conduct a new investigation on the transmission risk of SARS-COV-2 as virus/hazardous material through various environmental medias, routes and regions in the entirely urban area for guiding the SEERC. Specifically, 5 routes in 28 regions (totally 140 scenarios) are considered. For a new perspective, the risk evaluation is conducted by the quantification of frontline medicals staffs’ valuable experience in this work. 207 specialists responsible for the treatment of over 9000 infected patients are involved. The result showed that degree of risk was in the order of breath>contact-to-object>contact-to-human>intake>unknown. The modeling suggested source control as the prior measure for epidemic control. The combination of source control & mask wearing showed high efficiency in SEERC. The homeworking policy needed to cooperate with activity limitation to perform its efficiency. Subsequently, a new plan for SEERC was discussed. This work delivered significant information to researchers and decision makers for the further development of sustainable control for SARS-COV-2 spreading and COVID-19 epidemic.
|
|
