| 1. |
- Zhang, Jialin, et al.
(författare)
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FS-GBDT : identification multicancer-risk module via a feature selection algorithm by integrating Fisher score and GBDT
- 2021
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Ingår i: Briefings in Bioinformatics. - : Oxford University Press (OUP). - 1477-4054 .- 1467-5463. ; 22:3
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is a highly heterogeneous disease caused by dysregulation in different cell types and tissues. However, different cancers may share common mechanisms. It is critical to identify decisive genes involved in the development and progression of cancer, and joint analysis of multiple cancers may help to discover overlapping mechanisms among different cancers. In this study, we proposed a fusion feature selection framework attributed to ensemble method named Fisher score and Gradient Boosting Decision Tree (FS-GBDT) to select robust and decisive feature genes in high-dimensional gene expression datasets. Joint analysis of 11 human cancers types was conducted to explore the key feature genes subset of cancer. To verify the efficacy of FS-GBDT, we compared it with four other common feature selection algorithms by Support Vector Machine (SVM) classifier. The algorithm achieved highest indicators, outperforms other four methods. In addition, we performed gene ontology analysis and literature validation of the key gene subset, and this subset were classified into several functional modules. Functional modules can be used as markers of disease to replace single gene which is difficult to be found repeatedly in applications of gene chip, and to study the core mechanisms of cancer.
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| 2. |
- Allahgholi, Aschkan, et al.
(författare)
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Megapixels @ Megahertz – The AGIPD high-speed cameras for the European XFEL
- 2019
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 942
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Forskningsöversikt (refereegranskat)abstract
- The European XFEL is an extremely brilliant Free Electron Laser Source with a very demanding pulse structure: trains of 2700 X-ray pulses are repeated at 10Hz. The pulses inside the train are spaced by 220ns and each one contains up to 1012photons of 12.4keV, while being ≤100fs in length. AGIPD, the Adaptive Gain Integrating Pixel Detector, is a hybrid pixel detector developed by DESY, PSI, and the Universities of Bonn and Hamburg to cope with these properties. It is a fast, low noise integrating detector, with single photon sensitivity (for Eγ⪆6keV) and a large dynamic range, up to 104 photons at 12.4keV. This is achieved with a charge sensitive amplifier with 3 adaptively selected gains per pixel. 352 images can be recorded at up to 6.5MHz and stored in the in-pixel analogue memory and read out between pulse trains. The core component of this detector is the AGIPD ASIC, which consists of 64 × 64 pixels of 200µm×200µm. Control of the ASIC's image acquisition and analogue readout is via a command based interface. FPGA based electronic boards, controlling ASIC operation, image digitisation and 10GE data transmission interface AGIPD detectors to DAQ and control systems. An AGIPD 1Mpixel detector has been installed at the SPB1 experimental station in August 2017, while a second one is currently commissioned for the MID 2 endstation. A larger (4Mpixel) AGIPD detector and one to employ Hi-Z sensor material to efficiently register photons up to Eγ≈25keV are currently under construction.
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| 3. |
- Allahgholi, Aschkan, et al.
(författare)
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The Adaptive Gain Integrating Pixel Detector at the European XFEL
- 2019
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Ingår i: Journal of Synchrotron Radiation. - 0909-0495 .- 1600-5775. ; 26, s. 74-82
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Tidskriftsartikel (refereegranskat)abstract
- The Adaptive Gain Integrating Pixel Detector (AGIPD) is an X-ray imager, custom designed for the European X-ray Free-Electron Laser (XFEL). It is a fast, low-noise integrating detector, with an adaptive gain amplifier per pixel. This has an equivalent noise of less than 1keV when detecting single photons and, when switched into another gain state, a dynamic range of more than 10(4)photons of 12keV. In burst mode the system is able to store 352 images while running at up to 6.5MHz, which is compatible with the 4.5MHz frame rate at the European XFEL. The AGIPD system was installed and commissioned in August 2017, and successfully used for the first experiments at the Single Particles, Clusters and Biomolecules (SPB) experimental station at the European XFEL since September 2017. This paper describes the principal components and performance parameters of the system.
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| 4. |
- Fan, Ke, et al.
(författare)
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Amorphous WO3 induced lattice distortion for a low-cost and high-efficient electrocatalyst for overall water splitting in acid
- 2020
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Ingår i: Sustainable Energy & Fuels. - : ROYAL SOC CHEMISTRY. - 2398-4902. ; 4:4, s. 1712-1722
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Tidskriftsartikel (refereegranskat)abstract
- The development of highly active and durable catalysts for water oxidation under acidic conditions is necessary but challenging for renewable energy conversion. Ir-based catalysts are highly efficient for water oxidation in acid, but their large scale application is hindered by the high cost and scarcity of iridium. Herein, we use an amorphous WO3 induced lattice distortion (AWILD) strategy to reduce the Ir content to only 2 wt% in the final material. The optimized hybrid nitrogen-doped carbon (NC)/WO3/IrO2 can efficiently catalyze water oxidation with a low overpotential of 270 mV at 10 mA cm(-2) current density (eta (10)) and a high turnover frequency of over 2 s(-1) at 300 mV overpotential in 0.5 M H2SO4, a performance that surpasses that of commercial IrO2 significantly. Introducing the layer of amorphous WO3 between IrO2 nanoparticles and NC can distort the lattice of IrO2, exposing more highly active sites for water oxidation. The AWILD effect compensates for the lower Ir content and dramatically reduces the cost of the catalyst without sacrificing the catalytic activity. Additionally, this catalyst also exhibits high activity in acid for hydrogen evolution with only 65 mV of eta (10) attributed to the AWILD effect, exhibiting efficient bifunctionality as a Janus catalyst for overall water splitting. The AWILD approach provides a novel and efficient strategy for low-cost and highly efficient electrocatalysts for acidic overall water splitting with an extremely low content of noble metals.
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| 5. |
- Fan, Ke, et al.
(författare)
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Hollow Iron-Vanadium Composite Spheres : A Highly Efficient Iron-Based Water Oxidation Electrocatalyst without the Need for Nickel or Cobalt
- 2017
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Ingår i: Angewandte Chemie International Edition. - : WILEY-V C H VERLAG GMBH. - 1433-7851 .- 1521-3773. ; 56:12, s. 3289-3293
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Tidskriftsartikel (refereegranskat)abstract
- Noble-metal-free bimetal-based electrocatalysts have shown high efficiency for water oxidation. Ni and/or Co in these electrocatalysts are essential to provide a conductive, high-surface area and a chemically stable host. However, the necessity of Ni or Co limits the scope of low-cost electrocatalysts. Herein, we report a hierarchical hollow FeV composite, which is Ni- and Co-free and highly efficient for electrocatalytic water oxidation with low overpotential 390 mV (10 mA cm(-2) catalytic current density), low Tafel slope of 36.7 mV dec(-1), and a considerable durability. This work provides a novel and efficient catalyst, and greatly expands the scope of low-cost Fe-based electrocatalysts for water splitting without need of Ni or Co.
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| 6. |
- Wiedorn, Max O., et al.
(författare)
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Megahertz serial crystallography
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a beta-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
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| 7. |
- Zhang, Youzi, et al.
(författare)
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Gradient Heating Epitaxial Growth Gives Well Lattice-Matched Mo2C-Mo2N Heterointerfaces that Boost Both Electrocatalytic Hydrogen Evolution and Water Vapor Splitting
- 2022
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Ingår i: Angewandte Chemie International Edition. - : Wiley-Blackwell. - 1433-7851 .- 1521-3773. ; 61:47
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Tidskriftsartikel (refereegranskat)abstract
- An optimized approach to producing lattice-matched heterointerfaces for electrocatalytic hydrogen evolution has not yet been reported. Herein, we present the synthesis of lattice-matched Mo2C-Mo2N heterostructures using a gradient heating epitaxial growth method. The well lattice-matched heterointerface of Mo2C-Mo2N generates near-zero hydrogen-adsorption free energy and facilitates water dissociation in acid and alkaline media. The lattice-matched Mo2C-Mo2N heterostructures have low overpotentials of 73 mV and 80 mV at 10 mA cm(-2) in acid and alkaline solutions, respectively, comparable to commercial Pt/C. A novel photothermal-electrocatalytic water vapor splitting device using the lattice-matched Mo2C-Mo2N heterostructure as a hydrogen evolution electrocatalyst displays a competitive cell voltage for electrocatalytic water splitting.
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