| 1. |
- Kristan, Matej, et al.
(författare)
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The Sixth Visual Object Tracking VOT2018 Challenge Results
- 2019
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Ingår i: Computer Vision – ECCV 2018 Workshops. - Cham : Springer Publishing Company. - 9783030110086 - 9783030110093 ; , s. 3-53
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis and a “real-time” experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. A long-term tracking subchallenge has been introduced to the set of standard VOT sub-challenges. The new subchallenge focuses on long-term tracking properties, namely coping with target disappearance and reappearance. A new dataset has been compiled and a performance evaluation methodology that focuses on long-term tracking capabilities has been adopted. The VOT toolkit has been updated to support both standard short-term and the new long-term tracking subchallenges. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website (http://votchallenge.net).
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| 2. |
- Stanaway, Jeffrey D., et al.
(författare)
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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- 2018
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 392:10159, s. 1923-1994
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Tidskriftsartikel (refereegranskat)abstract
- Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk- outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk-outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017.
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| 3. |
- Wang, Longwei, et al.
(författare)
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A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
- 2023
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:11
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Tidskriftsartikel (refereegranskat)abstract
- The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.
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| 4. |
- Wang, Longwei, et al.
(författare)
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Regulation of functional groups enable the metal-free PDINH/GO advisable antibacterial photocatalytic therapy
- 2023
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Ingår i: Chemical Engineering Journal. - : Elsevier BV. - 1385-8947. ; 451
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Tidskriftsartikel (refereegranskat)abstract
- N-type organic semiconductor perylene-3,4,9,10-tetracarboxylic acid diimide (PDINH) are well-investigated photocatalyst. However, the photocatalytic potential for antibacterial therapy has been underexplored owing to the insufficient light absorption and rapid recombination of light-induced carriers. Herein, functional group-regulated is introduced by recrystallizing PDINH on the surface of GO in situ, endowing the PDINH/GO with enhanced photocatalytic properties, which harvest light energy across the full spectrum form ultraviolet to near-infrared. Simultaneously, the enhanced photogenerated carriers can activate Lewis base of GO to form an amide bond on the interface between bacteria and material, exhibiting high-efficient and steady bacteria trap. Compared with PDINH, both in vitro and in vivo all demonstrated PDINH/GO possess excellent antibacterial effect. In addition, as a non-metallic semiconductor, PDINH/GO shows capacity of enhancing epidermal cells proliferation and migration, resulting in successful infectious wound regeneration in mice and the side effects in vivo are negligible. Such the integration of wide-spectrum response, high efficiency of carrier separation, intentional bacterial capture and accelerated would healing of PDINH/GO not only enables an effective antibacterial therapy but also contributes to a successful example to activate nanomaterials by regulation of functional groups.
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| 5. |
- Wang, Longwei, et al.
(författare)
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Construction of S-N-C bond for boosting bacteria-killing by synergistic effect of photocatalysis and nanozyme
- 2023
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Ingår i: Applied Catalysis B: Environmental. - : Elsevier BV. - 0926-3373 .- 1873-3883. ; 325
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Tidskriftsartikel (refereegranskat)abstract
- Bacterial infection-related diseases are major public safety issues leads to millions of deaths annually. Herein, a porous sulfur doped graphitic carbon nitride (g-SCN) for ecofriendly, metal-free and low systemic toxicity were synthesized. Sulfur doping enables to broaden the absorption spectrum and promote the photocarriers separation for photocatalysis enhancement. Moreover, sulfur element will coordinate with nitrogen, changing the electronic state and endowing g-SCN with the property of nanozyme. More importantly, we established different models and confirmed that S-N-C coordination is the source of peroxidase (POD)-like activity through theory and experiment. The increased specific surface area of g-SCN, ascribing to the porous structure, makes it easier to trap bacteria. With the synergistic effect of photocatalysis and nanozyme, the prepared g-SCN has the ability to kill both gram-negative and gram-positive bacterium, with an antibacterial efficiency up to 100%. This work provides innovative synergistic strategy for constructing nanomaterials for highly efficient antibacterial therapy.
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| 6. |
- Yang, Zhongwei, et al.
(författare)
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Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment
- 2023
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Ingår i: Nano Today. - : Elsevier BV. - 1878-044X .- 1748-0132. ; 49
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Forskningsöversikt (refereegranskat)abstract
- Cancer is still the leading disease threatening human life and health at present. With the development of nanotechnology, multifunctional nanomaterials integrated with different diagnostic and therapeutic functions have become the most active field in nano-research. Among them, Bi2S3-based nanomaterials have attracted great attention in the biomedical field due to their special photothermal effect and biocompatibility. In this review, we systematically summarize the synthetic strategies and their physical-chemical properties of Bi2S3-based nanomaterials. Then we outline the recent research progress in the diagnosis and treatment of cancer, which are highlighted and discussed in detail. In addition, the safety and biodistribution of Bi2S3-based nanomaterials are emphasized and discussed. It is believed that the emerging Bi2S3-based nanomaterials may realize the practical applications via unremitting efforts of scientific researchers in the near future.
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| 7. |
- Yang, Zhongwei, et al.
(författare)
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Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment
- 2023
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Ingår i: Kexue Tongbao/Chinese Science Bulletin. - 0023-074X .- 2095-9419. ; 68:16, s. 2101-2115
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is a complicated disease with a significant degree of heterogeneity, despite having made impressive advances in the field of cancer treatment, cancer remains a major threat to human life and health. The complexity of cancer on the genetic and phenotypic planes defines its clinical diversity and the difficulty of treatment. The increasing incidence of integrative types as well as individual types of cancer with the passage of time has prompted the development of novel cancer treatment strategies. Current treatment protocols are based on correcting gene mis-expression, blocking nutrient delivery to the tumor, or destroying the cancer cells. Often, surgery cannot completely eliminate all cancer cells in the body, leaving the cancer at risk of recurrence and high mortality. Chemotherapy and radiotherapy have serious side effects on normal tissue cells in the body while killing cancer cells, and these approaches are still unsatisfactory due to insufficient specificity and dose limitations. The development of novel drugs with specific targeted therapies or site-specific delivery systems to deliver therapeutic agents can greatly avoid the toxicity to healthy tissues caused by non-specificity. The preparation of nanomaterials is the most important basic technology in nanotechnology research, as well as a prerequisite for nanoapplication technology and nano-industrialization, which has been the key focus of nanotechnology researchers’ attention and research. With the development of nanotechnology, multifunctional nanomaterials, which integrate various diagnostic and therapeutic functions, have become the most active field in nanoscale research, and have been applied in the fields of early screening of tumors, identification of tumor biomarkers, targeted release of chemotherapeutic drugs and development of novel therapies. After decades of development, biomedical nanomaterials have been applied to cancer diagnosis, tumor imaging, drug loading, tumor therapy, etc. They have excellent biocompatibility and biodistribution, with advantages unmatched over traditional therapeutic methods. Among them, Bi2S3 based nanomaterials have attracted great attention in the biomedical field due to their special photothermal effect and biocompatibility, etc. The authors summarize the preparation methods of Bi2S3 based nanomaterials with different morphological dimensions reported in the literature, as well as effective strategies for constructing different heterogeneous structures. Currently, Bi2S3 based nanomaterials have been widely used in cancer diagnosis. The main strategy is the combination of various functionalized probe-loaded Bi2S3 with various imaging methods to determine tumor boundaries, histological analysis and 3D stereoscopic imaging detection. Meanwhile, due to its superior photothermal conversion efficiency and X-ray attenuation coefficient, Bi2S3 based nanomaterials have been widely used in a range of fields such as photothermal therapy, photodynamic therapy, radio sensitization therapy, immunotherapy and chemotherapy by means of rational modifications and loading. Since individual imaging modalities cannot provide complete information about the tumor treatment, Bi2S3 based nanomaterials with multimodal imaging capabilities can enable real-time monitoring of tumors and real-time observation of therapeutic agent metabolism, providing guidance for tumor treatment. In addition, a mono-therapeutic approach is often unable to completely inhibit and kill tumors, so Bi2S3 based nanomaterials integrating multiple therapeutic approaches can not only reduce the dose of chemotherapeutic drugs, but also cause serious damage to tumor cells and inhibit the metastasis of cancer cells, which greatly reduces the possibility of tumor recurrence and is of great significance for a favorable prognosis of tumor treatment. Finally, the authors highlight and discuss the biosafety and biodistribution of Bi2S3 based nanomaterials, as well as summarize methods to improve the biocompatibility of nanoparticles, providing indicative clues for further biosafety applications of Bi2S3 based nanomaterials.
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| 8. |
- Yu, Xin, et al.
(författare)
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Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application
- 2023
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Ingår i: Small. - 1613-6810 .- 1613-6829. ; 19:52
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Forskningsöversikt (refereegranskat)abstract
- Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme activity by generating positive and negative charges on piezoelectric materials' surfaces. This article comprehensively reviews the potential mechanisms and practical applications of regulating nanozyme activity through the piezoelectric effect. The article first elucidates how the piezoelectric effect enables nanozymes to exhibit catalytic activity. It is highlighted that the positive and negative charges produced by this effect directly participate in redox reactions, leading to the conversion of materials from an inactive to an active state. Moreover, the piezoelectric field generated can enhance nanozyme activity by accelerating electron transfer rates or reducing binding energy between nanozymes and substrates. Practical applications of piezoelectric nanozymes are explored in the subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, and tumor therapy, which demonstrate the versatile potentials of the piezoelectric effect in nanozyme applications. The review concludes by emphasizing the need for further research into the catalytic mechanisms of piezoelectric nanozymes, suggesting expanding the scope of catalytic types and exploring new application areas. Furthermore, the promising direction of synergistic catalytic therapy is discussed as an inspiring avenue for future research.
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| 9. |
- Yu, Xin, et al.
(författare)
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Recent Development of Copper-Based Nanozymes for Biomedical Applications
- 2024
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Ingår i: Advanced healthcare materials. - 2192-2640 .- 2192-2659. ; 13:1
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Forskningsöversikt (refereegranskat)abstract
- Copper (Cu), an indispensable trace element within the human body, serving as an intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known as nanozymes, possess distinct advantages over their natural enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated the attention of researchers, inspiring them to devise various Cu-based nanomaterials, such as copper oxide, Cu metal-organic framework, and CuS, and explore their potential in enzymatic catalysis. This comprehensive review encapsulates the most recent advancements in Cu-based nanozymes, illuminating their applications in the realm of biochemistry. Initially, it is delved into the emulation of typical enzyme types achieved by Cu-based nanomaterials. Subsequently, the latest breakthroughs concerning Cu-based nanozymes in biochemical sensing, bacterial inhibition, cancer therapy, and neurodegenerative diseases treatment is discussed. Within this segment, it is also explored the modulation of Cu-based nanozyme activity. Finally, a visionary outlook for the future development of Cu-based nanozymes is presented.
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| 10. |
- Zhang, Jing, 1989-
(författare)
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Creep modeling and first-principles investigation of high-temperature alloys
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Stainless steels and nickel-based superalloys are materials that have been widely used to manufacture components servicing at high temperatures. Creep strength is one of the most important properties in such conditions. High creep strength generally comes from a combination of solid solution hardening, precipitation hardening and dislocation hardening. However, some details of the mechanism of solid solution hardening are still not fully understood. The present thesis can be separated into two parts.In the first part, fundamental creep models are used in an investigation of creep rate of nickel-based alloys. The fundamental models are based on dislocation theories without using any adjustable parameters to describe the creep data. All parameters in the models have been derived from experimental data or using computational approaches such as ab initio methods. In the models, the effects of stacking faults, strain-induced vacancies and pipe diffusion have been taken into account. W is a vital element to create solid solution hardening and improve creep strength of nickel-based alloys. W readily dissolves in nickel to form a solid solution and to provide a significant effect on the creep strength. Moreover, many ternary and more complex systems of nickel-based alloys are developed starting from Ni-W solid solutions. The developed models can describe the dramatic reduction of the creep rate due to W, which has not been possible in the past. The reduction has a close correlation with the stacking fault energy and drag stress.In the second part, the exact muffin-tin orbital method combined with the coherent potential approximation has been interfaced with a quasi-harmonic Debye model to predict the elastic and other thermodynamic properties of selected metallic alloys at high temperature. The knowledge of such properties is very useful in modeling the behavior of materials servicing at high temperatures. However, few experimental studies have been focused on measurements of thermo-mechanical properties at such temperatures. Ab initio methods based on density functional theory is an alternative way to obtain information about thermo-mechanical properties. Therefore, in the present work, ab initio based studies of the elastic and thermodynamic properties of pure nickel, nickel-based solid solutions and Fe25Cr20NiMnNb austenitic stainless steel have been performed. Although the modeling technique cannot fully reproduce the temperature dependencies in some of the considered cases where experimental data are available, the computed values of such properties as shear moduli, thermal expansion coefficients and entropy are close to the experimentally derived values.
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