| 1. |
- Jing, Shuping, et al.
(författare)
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Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease
- 2019
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Ingår i: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 25:9, s. 1756-1758
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Tidskriftsartikel (refereegranskat)abstract
- We identified a case of fatal acute respiratory disease from household transmission of human adenovirus type 55 (HAdV-55) in Anhui Province, China. Computed tomography showed severe pneumonia. Comparative genomic analysis of HAdV-55 indicated the virus possibly originated in Shanxi Province, China. More attention should be paid to highly contagious HAdV-55.
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| 2. |
- Zhang, Yuan, et al.
(författare)
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Quantitative Proteomics of TRAMP Mice Combined with Bioinformatics Analysis Reveals That PDGF-B Regulatory Network Plays a Key Role in Prostate Cancer Progression
- 2018
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 17:7, s. 2401-2411
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Tidskriftsartikel (refereegranskat)abstract
- Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice is a widely used transgenic animal model of prostate cancer (PCa). We performed a label-free quantitative proteomics analysis combined with a bioinformatics analysis on the entire prostate protein extraction from TRAMP mice and compared it with WT littermates. From 2379 total identified proteins, we presented a modest mice prostate reference proteome containing 919 proteins. 61 proteins presented a significant expression difference between two groups. The integrative bioinformatics analysis predicted the overexpression of platelet-derived growth factor B (PDGF-B) in tumor tissues and supports the hypothesis of the PDGF-B signaling network as a key upstream regulator in PCa progression. Furthermore, we demonstrated that Crenolanib, a novel PDGF receptor inhibitor, inhibited PCa cell proliferation in a dose-dependent manner. Finally, we revealed the importance of PDGF-B regulatory network in PCa progression, which will assist us in understanding the role and mechanisms of PDGF-B in promoting cancer growth and provide valuable knowledge for future research on anti-PDGF therapy.
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| 3. |
- Lu, Xuedong, et al.
(författare)
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A rapid two-step algorithm detects and identifies clinical macrolide and beta-lactam antibiotic resistance in clinical bacterial isolates
- 2014
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Ingår i: Journal of Microbiological Methods. - : Elsevier BV. - 0167-7012 .- 1872-8359. ; 102, s. 26-31
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Aiming to identify macrolide and beta-lactam resistance in clinical bacterial isolates rapidly and accurately, a two-step algorithm was developed based on detection of eight antibiotic resistance genes. Methods: Targeting at genes linked to bacterial macrolide (msrA, ermA, ermB, and ermC) and beta-lactam (bla(TEM), bla(SHV), bla(CTX-N-1), bin(CTX-M-9)) antibiotic resistances, this method includes a multiplex real-time PCR, a melting temperature profile analysis as well as a liquid bead microarray assay. Liquid bead microarray assay is applied only when indistinguishable T-m profile is observed. Results: The clinical validity of this method was assessed on clinical bacterial isolates. Among the total 580 isolates that were determined by our diagnostic method, 75% of them were identified by the multiplex real-time PCR with melting temperature analysis alone, while the remaining 25% required both multiplex real-time PCR with melting temperature analysis and liquid bead microarray assay for identification. Compared with the traditional phenotypic antibiotic susceptibility test, an overall agreement of 81.2% (kappa = 0.614, 95% Cl = 0550-0.679) was observed, with a sensitivity and specificity of 87.7% and 73% respectively. Besides, the average test turnaround time is 3.9 h, which is much shorter in comparison with more than 24 h for the traditional phenotypic tests. Conclusions: Having the advantages of the shorter operating time and comparable high sensitivity and specificity with the traditional phenotypic test, our two-step algorithm provides an efficient tool for rapid determination of macrolide and beta-lactam antibiotic resistances in clinical bacterial isolates.
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| 4. |
- Wei, Xiaodan, et al.
(författare)
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The Number of Stenotic Intracranial Arteries Is Independently Associated with Ischemic Stroke Severity
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:9
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Tidskriftsartikel (refereegranskat)abstract
- Background The severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear. Aims We aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors. Methods We performed a retrospective analysis of patients with digital subtraction angiography (DSA)-confirmed ischemic stroke. Clinical stroke severity was measured using the National Institutes of Health Stroke Scale (NIHSS). The number of stenotic vessels was counted from the internal carotid arteries and vertebral arteries, bilaterally. Results Eighty three patients were recruited from a single center and included in the study. NSMIA was significantly correlated with stroke severity (Pearson Correlation Coefficient = 0.485, P < 0.001), but not with the degree of stenosis (Pearson Correlation Coefficient = 0.01, P = 0.90). Multivariate regression analysis revealed that NSMIA was significantly associated with the NIHSS score after adjusting for stroke risk factors. The adjusted odds ratio (per lateral) was 2.092 (95% CI, 0.865 to 3.308, P = 0.001). The degree of stenosis was also significantly associated with the NIHSS score after adjusting for common risk factors. The odds ratio (per 10%) was 0.712 (95% CI, 0.202 to 1.223, P = 0.007). Conclusions The number of stenotic intracranial major arteries is associated with the severity of ischemic stroke independent of the degree of stenosis and other stroke risk factors. To the best of our knowledge, this has not been previosuly studied in great detail using DSA. Our data highlight the importance of examining all major arteries in stroke patients.
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| 5. |
- Zhang, Li, et al.
(författare)
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Electron-Withdrawing Anchor Group of Sensitizer for Dye-Sensitized Solar Cells, Cyanoacrylic Acid, or Benzoic Acid?
- 2020
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Ingår i: Solar RRL. - : Wiley. - 2367-198X. ; 4:3
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Tidskriftsartikel (refereegranskat)abstract
- High electron-injection efficiency is important for further development of dye-sensitized solar cells (DSSCs). Different electron acceptors have different electron-injection capabilities, which affect device performance. Herein, the effects of two organic triazatruxene (TAT)-based donor-pi-bridge-acceptor sensitizers applied in DSSCs are reported. The sensitizers have either rigid 4-ethynyl benzoic acid (EBA) or Z-type cyanoacrylic acid (CA) as their electron acceptor, denoted as ZL003 and ZL005, respectively. Time-resolved photoluminescence (TR-PL) spectroscopy is applied to reveal the electron transfer dynamics between the sensitizers and TiO2 films. Notably, ZL003 has higher electron-injection efficiency compared with that of ZL005, which is consistent with the higher efficiency and photocurrent of devices based on the former. The dye loading of ZL003 is nearly twice as great as that of ZL005, which accounts for the lower photocurrent of the device. The charge recombination lifetimes for the two dyes are consistent with their open-circuit voltage. Consequently, the ZL003-based devices achieve a higher power conversion efficiency of 13.4% compared with only 7.2% for ZL005.
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| 6. |
- Zhang, Shuping, et al.
(författare)
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Invasive Rosa rugosa populations outperform native populations, but some populations have greater invasive potential than others
- 2018
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Increased performance of invasive plant species in their introduced range vs. their native range has been previously documented. However, performance differences among invasive populations have rarely been explored, despite this information being central to understanding the evolution of invasiveness as well as being a useful basis to inform management of invasive species. To examine variation in performance among populations of Rosa rugosa in its introduced range, and whether introduced populations perform better than native populations, we quantified growth and reproductive traits in five invasive populations in northwest Europe and two native and declining populations in China. Overall, we found that the introduced R. rugosa populations we sampled performed significantly better than the sampled native populations for growth and reproductive traits (2 to 4 fold increase). However, there was significant variation for most traits among the five invasive populations, demonstrating that some introduced populations we sampled were more successful invaders than others. Our findings provide a useful foundation for management of invasive R. rugosa in Europe, and support the recent call for more intra-species research in invasive species biology.
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| 7. |
- Zhang, Shuping, et al.
(författare)
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Mapping coastal upwelling in the Baltic Sea from 2002 to 2020 using remote sensing data
- 2022
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Ingår i: International Journal of Applied Earth Observation and Geoinformation. - : Elsevier. - 1569-8432 .- 1872-826X. ; 114
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Tidskriftsartikel (refereegranskat)abstract
- Coastal upwelling (CU) is an elementary phenomenon in coastal waters. CU brings up deep, often cold, saline water rich of nutrients and carbon, and plays a vital role in local air-sea exchange of gases and heat, marine ecosystem maintenance, and ocean physical dynamics. In this study, regional CU in the Baltic Sea was mapped on the daily MODIS SST from 2002 to 2020, using a method modified developed by Lehmann et al. (2012). Based on the individual CU event detected, the spatiotemporal distribution of CU in the Baltic Sea was depicted, the CU-wind relationship and potential CU drivers in the Baltic Sea on different temporal scale were analyzed. The results found that: 1) The modified approach can effectively delineate the CUs formed by upwelled cold water; 2) The 19 zones delineated with frequent CU occurrences aligned well with previous study and the overall CU occurrence spatial heterogeneity was casted by the different directional relationship between the local coastline and wind; 3) The occurrences of the CU detected in this study showed strong seasonality and primarily driven by SST seasonality and then intensified by local wind in fall; 4) The interannual difference of CU occurrences were affected by heatwaves and its monthly timing. The CUs detected in this study have a high potential for facilitating investigations with respect to oceanic modeling, air-sea exchange of heat and greenhouse gases, and physical dynamics in the Baltic Sea.
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| 8. |
- Zhang, Shuping, et al.
(författare)
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Mapping regional surface water volume variation in reservoirs in northeastern Brazil during 2009–2017 using high-resolution satellite images
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 789
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Tidskriftsartikel (refereegranskat)abstract
- The multiple-year drought that started in 2011 and reached climax in 2015 was the most severe and prolonged one in the semiarid northeastern (NE) Brazil in recent decades. This study aimed to investigate the reservoir surface water volume (SWV) variation in NE Brazil from 2009 to 2017 in four representative regions covering a total area of approximately 10,000 km2 there and encompassing 2,140 reservoirs (areas range from 0.003 to 21 km2). High-resolution (10 m) digital elevation models (DEMs) were generated from the TanDEM-X data acquired during October–December 2015 to represent the reservoirs' bathymetric maps. The water extents in the reservoirs were delineated from high-resolution (6.5 m) RapidEye images acquired during 2009–2017. The combination of the aforementioned two variables yielded reservoir SWV with an accuracy of 0.64 × 106–1.06 × 106 m3, corresponding to 3.1%–5.6% of the maximum SWV in the reservoirs. The results showed that: 1) 81%–99% of the reservoirs in the four regions were from the groups with maximum water extent <50 ha and contributed 2%–59% of the regional reservoir SWV. In contrast, 0.6%–20% of the reservoirs were from the group of >50 ha and contributed 40%–98% to the regional SWV; 2) From 2009 to 2017, reservoir SWV in the four regions decreased at the rates of 2.3 × 106–17.8 × 106 m3/year; and 3) The SWV in the reservoirs responded differently to the regional terrestrial water budget, i.e. the differences between precipitation and evapotranspiration (P-ET). This study filled the data gap of bathymetric maps for the 2140 reservoirs, regardless of their sizes and macrophyte coverage. The SWV variations derived in those reservoirs over a period covering the recent drought can support better preparedness for drought in NE Brazil and better understanding of the regional hydrology in semi-arid regions.
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| 9. |
- Zhang, Shuping, et al.
(författare)
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Remote Sensing Supported Sea Surface pCO(2) Estimation and Variable Analysis in the Baltic Sea
- 2021
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Ingår i: Remote Sensing. - : MDPI. - 2072-4292. ; 13:2
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Tidskriftsartikel (refereegranskat)abstract
- Marginal seas are a dynamic and still to large extent uncertain component of the global carbon cycle. The large temporal and spatial variations of sea-surface partial pressure of carbon dioxide (pCO(2)) in these areas are driven by multiple complex mechanisms. In this study, we analyzed the variable importance for the sea surface pCO(2) estimation in the Baltic Sea and derived monthly pCO(2) maps for the marginal sea during the period of July 2002-October 2011. We used variables obtained from remote sensing images and numerical models. The random forest algorithm was employed to construct regression models for pCO(2) estimation and produce the importance of different input variables. The study found that photosynthetically available radiation (PAR) was the most important variable for the pCO(2) estimation across the entire Baltic Sea, followed by sea surface temperature (SST), absorption of colored dissolved organic matter (a(CDOM)), and mixed layer depth (MLD). Interestingly, Chlorophyll-a concentration (Chl-a) and the diffuse attenuation coefficient for downwelling irradiance at 490 nm (Kd_490nm) showed relatively low importance for the pCO(2) estimation. This was mainly attributed to the high correlation of Chl-a and Kd_490nm to other pCO(2)-relevant variables (e.g., a(CDOM)), particularly in the summer months. In addition, the variables' importance for pCO(2) estimation varied between seasons and sub-basins. For example, the importance of a(CDOM) were large in the Gulf of Finland but marginal in other sub-basins. The model for pCO(2) estimate in the entire Baltic Sea explained 63% of the variation and had a root of mean squared error (RMSE) of 47.8 mu atm. The pCO(2) maps derived with this model displayed realistic seasonal variations and spatial features of sea surface pCO(2) in the Baltic Sea. The spatially and seasonally varying variables' importance for the pCO(2) estimation shed light on the heterogeneities in the biogeochemical and physical processes driving the carbon cycling in the Baltic Sea and can serve as an important basis for future pCO(2) estimation in marginal seas using remote sensing techniques. The pCO(2) maps derived in this study provided a robust benchmark for understanding the spatiotemporal patterns of CO2 air-sea exchange in the Baltic Sea.
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| 10. |
- Zhang, X. G., et al.
(författare)
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The Study on Cracking Strength of AIJs to Release the Early-Age Stress of Mass Concrete
- 2015
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Ingår i: Advances in Materials Science and Engineering. - : Hindawi Limited. - 1687-8442 .- 1687-8434. ; 2015
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to theoretically and numerically assess the effect of setting artificial-induced joints (AIJs) during construction period of amass concrete structure to release the early-stage thermal stress. With respect to the coupling influences of various factors such as size and boundary of AIJs, an analytical model for its cracking strength on the setting section of mass concrete is proposed based on double-parameter fracture theory. A kind of hyper-finite element analysis (FEA) for many array AIJs in simplified plane pate is also presented by using bilinear cohesive force distribution. The results from the present model and numerical simulation were compared to those of experimental data to prove the efficiency and accuracy of the analytical model and FEA. The model presented in this study for the cracking strength of AIJs provides a simple useful tool to accurately evaluate how many early stress AIJs reduced. The theoretical solution and FEA results could also be significantly contributed to find the "just" and "perfect" release of the temperature stress and to improve the design level of AIJs in mass concrete structure.
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