| 1. |
- Chaillou, Thomas, 1985-, et al.
(författare)
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Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth
- 2016
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Ingår i: Journal of Cellular Physiology. - : Wiley-Blackwell. - 0021-9541 .- 1097-4652. ; 231:9, s. 1894-1902
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Tidskriftsartikel (refereegranskat)abstract
- The ribosome has historically been considered to have no cell-specific function but rather serve in a "housekeeping" capacity. This view is being challenged by evidence showing that heterogeneity in the protein composition of the ribosome can lead to the functional specialization of the ribosome. Expression profiling of different tissues revealed that ribosomal protein large 3-like (Rpl3l) is exclusively expressed in striated muscle. In response to a hypertrophic stimulus, Rpl3l expression in skeletal muscle was significantly decreased by 82% whereas expression of the ubiquitous paralog Rpl3 was significantly increased by ∼fivefold. Based on these findings, we developed the hypothesis that Rpl3l functions as a negative regulator of muscle growth. To test this hypothesis, we used the Tet-On system to express Rpl3l in myoblasts during myotube formation. In support of our hypothesis, RPL3L expression significantly impaired myotube growth as assessed by myotube diameter (-23%) and protein content (-14%). Further analysis showed that the basis of this impairment was caused by a significant decrease in myoblast fusion as the fusion index was significantly lower (-17%) with RPL3L expression. These findings are the first evidence to support the novel concept of ribosome specialization in skeletal muscle and its role in the regulation of skeletal muscle growth.
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| 2. |
- Guo, Junji, et al.
(författare)
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Unprecedented Electrochromic Stability of a-WO3-x Thin Films Achieved by Using a Hybrid-Cationic Electrolyte
- 2021
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 13:9, s. 11067-11077
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Tidskriftsartikel (refereegranskat)abstract
- With large interstitial space volumes and fast ion diffusion pathways, amorphous metal oxides as cathodic intercalation materials for electrochromic devices have attracted attention. However, these incompact thin films normally suffer from two inevitable imperfections: self-deintercalation of guest ions and poor stability of the structure, which constitute a big obstacle toward the development of high-stable commercial applications. Here, we present a low-cost, eco-friendly hybrid cation 1,2-PG-AlCl3 center dot 6H(2)O electrolyte, in which the sputter-deposited a-WO3-x thin film can exhibit both the long-desired excellent open-circuit memory (>100 h, with zero optical loss) and super-long cycling lifetime (similar to 20,000 cycles, with 80% optical modulation), benefiting from the formation of unique Al-hydroxide-based solid electrolyte interphase during electrochromic operations. In addition, the optical absorption behaviors in a-WO3-x caused by host-guest interactions were elaborated. We demonstrated that the intervalence transfers are primarily via the "corner-sharing" related path (W5+ <-> W6+) but not the "edge-sharing" related paths (W4+ <-> W6+ and/or W4+ <-> W5+), and the small polaron/electron transfers taking place at the W-O bond-breaking positions are not allowed. Our findings might provide in-depth insights into the nature of electrochromism and provide a significant step in the realization of more stable, more excellent electrochromic applications based on amorphous metal oxides.
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| 3. |
- Hu, Xiping, et al.
(författare)
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Crowdsourcing for Mobile Networks and IoT
- 2018
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Ingår i: Wireless Communications & Mobile Computing. - : WILEY-HINDAWI. - 1530-8669 .- 1530-8677.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 5. |
- Zhang, Jiao, et al.
(författare)
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Joint Resource Allocation for Latency-Sensitive Services Over Mobile Edge Computing Networks With Caching
- 2019
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Ingår i: IEEE Internet of Things Journal. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2327-4662. ; 6:3, s. 4283-4294
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Tidskriftsartikel (refereegranskat)abstract
- Mobile edge computing (MEC) has risen as a promising paradigm to provide high quality of experience via relocating the cloud server in close proximity to smart mobile devices (SMDs). In MEC networks, the MEC server with computation capability and storage resource can jointly execute the latency-sensitive offloading tasks and cache the contents requested by SMDs. In order to minimize the total latency consumption of the computation tasks, we jointly consider computation offloading, content caching, and resource allocation as an integrated model, which is formulated as a mixed integer nonlinear programming (MINLP) problem. We design an asymmetric search tree and improve the branch and bound method to obtain a set of accurate decisions and resource allocation strategies. Furthermore, we introduce the auxiliary variables to reformulate the proposed model and apply the modified generalized benders decomposition method to solve the MINLP problem in polynomial computation complexity time. Simulation results demonstrate the superiority of the proposed schemes.
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