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- Zhao, Changhong, 1984, et al.
(författare)
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Graphene oxide based coatings on Nitinol for biomedical implant applications: Effectively promote mammalian cell growth but kill bacteria
- 2016
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 6:44, s. 38124-38134
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Tidskriftsartikel (refereegranskat)abstract
- © The Royal Society of Chemistry 2016. An important clinical challenge is the development of implant surfaces which have good integration with the surrounding tissues and simultaneously inhibit bacterial colonization thus preventing infection. Recently, graphene oxide (GO) a derivative of graphene, has gained considerable attention in the biomedical field owing to its biocompatibility, surface functionalizability and promising antimicrobial activity. In this study gelatin-functionalized graphene oxide (GOGel) was synthesized by a simple one step modification where GO and GOGel were used to develop surface coatings on nitinol substrates. Mouse osteoblastic cell (MC3T3-E1) functions including cell attachment, proliferation and differentiation were investigated on GO-based coatings. The results indicated that MC3T3-E1 cell functions were significantly enhanced on both GO coated nitinol (GO@NiTi) and GOGel coated nitinol (GOGel@NiTi) compared with the control nitinol without coating (NiTi). Especially, the GOGel@NiTi surface exhibited the best performance for cell adhesion, proliferation and differentiation. Additionally the antimicrobial property of GO-based coatings against E. coli was studied with the evaluation of colony forming units (CFU) counting, live/dead fluorescent staining and scanning electron microscope (SEM). We found that the growth of E. coli was inhibited on GOGel@NiTi and particularly on GO@NiTi. SEM images revealed that the cell membrane of bacteria lost their integrity and live/dead fluorescent images confirmed the low live/dead ratio of E. coli after incubation on GOGel@NiTi and GO@NiTi. We conclude that GO-based coatings on NiTi combine the antimicrobial activity and improved biocompatibility and therefore present a remarkable potential in biomedical implant applications.
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- Wang, Nan, 1988, et al.
(författare)
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Efficient surface modification of carbon nanotubes for fabricating high performance CNT based hybrid nanostructures
- 2017
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Ingår i: Carbon. - : Elsevier BV. - 0008-6223. ; 111, s. 402-410
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotubes (CNTs) were chemically modified to achieve strong binding strength with the attached functional components as well as good dispersability and nanoparticle size-uniformity. An efficient multi-oxidation process was developed to create porous out layer with many nanoscale defects on the surface of CNTs for metallic nanoparticle close attachment and bond sufficient oxygen-containing groups, which assisted the dispersion of CNTs in the aqueous solution. The surface modified CNTs have advantages of strong binding capability, large surface area, high mechanical strength and good dispersability, which show great potential as building blocks for hybrid nanomaterials. Monodispersed silver nano particles with an average size of 3 nm were formed from inside the created nanoscale defects on the surface of CNTs without any obvious agglomerations. The fabricated hybrid exhibited much enhanced anti-bacterial performance compared to commercial silver nanoparticles due to the combined antibacterial effects of CNTs and silver nanoparticles. With these superior properties, the developed surface modification process could be widely used for improving the performances of many CNT based hybrid nanomaterials in diverse applications.
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- Zhao, Changhong, 1982, et al.
(författare)
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Synthesis of graphene quantum dots and their applications in drug delivery
- 2020
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Ingår i: Journal of Nanobiotechnology. - : Springer Science and Business Media LLC. - 1477-3155. ; 18:1
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Forskningsöversikt (refereegranskat)abstract
- This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.[Figure not available: see fulltext.]
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