| 1. |
- Du, Jiawei, et al.
(författare)
-
Proteomic profiling of muscular adaptations to short-term concentric versus eccentric exercise training in humans
- 2024
-
Ingår i: Molecular & Cellular Proteomics. - : Elsevier. - 1535-9476 .- 1535-9484. ; 23:4
-
Tidskriftsartikel (refereegranskat)abstract
- The molecular mechanisms underlying muscular adaptations to concentric (CON) and eccentric (ECC) exercise training have been extensively explored. However, most previous studies have focused on specifically selected proteins, thus, unable to provide a comprehensive protein profile and potentially missing the crucial mechanisms underlying muscular adaptation to exercise training. We herein aimed to investigate proteomic profiles of human skeletal muscle in response to short-term resistance training. Twenty young males were randomly and evenly assigned to two groups to complete a 4-week either ECC or CON training program. Measurements of body composition and physiological function of the quadriceps femoris were conducted both before and after the training. Muscle biopsies from the vastus lateralis of randomly selected participants (five in ECC and four in CON) of both before and after the training were analyzed using the liquid-chromatography tandem mass spectrometry in combination with bioinformatics analysis. Neither group presented a significant difference in body composition or leg muscle mass; however, muscle peak torque, total work, and maximal voluntary contraction were significantly increased after the training in both groups. Proteomics analysis revealed 122 differentially abundant proteins (DAPs; p value < 0.05 & fold change >1.5 or <0.67) in ECC, of which the increased DAPs were mainly related to skeletal muscle contraction and cytoskeleton and enriched specifically in the pentose phosphate pathway, extracellular matrix-receptor interaction, and PI3K-Akt signaling pathway, whereas the decreased DAPs were associated with the mitochondrial respiratory chain. One hundred one DAPs were identified in CON, of which the increased DAPs were primarily involved in translation/ protein synthesis and the mitochondria respiratory, whereas the decreased DAPs were related to metabolic processes, cytoskeleton, and de-ubiquitination. In conclusion, the 4-week CON and ECC training resulted in distinctly different proteomic profiles, especially in proteins related to muscular structure and metabolism.
|
|
| 2. |
- Garnier, Nicolas, et al.
(författare)
-
Genetic newborn screening and digital technologies : A project protocol based on a dual approach to shorten the rare diseases diagnostic path in Europe
- 2023
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 18:11
-
Tidskriftsartikel (refereegranskat)abstract
- Since 72% of rare diseases are genetic in origin and mostly paediatrics, genetic newborn screening represents a diagnostic "window of opportunity". Therefore, many gNBS initiatives started in different European countries. Screen4Care is a research project, which resulted of a joint effort between the European Union Commission and the European Federation of Pharmaceutical Industries and Associations. It focuses on genetic newborn screening and artificial intelligence-based tools which will be applied to a large European population of about 25.000 infants. The neonatal screening strategy will be based on targeted sequencing, while whole genome sequencing will be offered to all enrolled infants who may show early symptoms but have resulted negative at the targeted sequencing-based newborn screening. We will leverage artificial intelligence-based algorithms to identify patients using Electronic Health Records (EHR) and to build a repository "symptom checkers" for patients and healthcare providers. S4C will design an equitable, ethical, and sustainable framework for genetic newborn screening and new digital tools, corroborated by a large workout where legal, ethical, and social complexities will be addressed with the intent of making the framework highly and flexibly translatable into the diverse European health systems.
|
|
| 3. |
- Guo, Jiawei, et al.
(författare)
-
Bimetallic Sulfides with Vacancy Modulation Exhibit Enhanced Electrochemical Performance
- 2024
-
Ingår i: Advanced Functional Materials. - 1616-3028 .- 1616-301X. ; 34:28
-
Tidskriftsartikel (refereegranskat)abstract
- Transition bimetallic sulfides show significant promise for energy-related applications because of their plentiful active sites and synergistic redox activity. However, limited pore size and low-conductivity issues hinder their application. The structure of NiCo-S with rich sulfur vacancies is first predicted by density functional theory (DFT) calculations. Different sulfur vacancy concentrations are modeled by DFT calculations, and the results confirm that sulfur vacancies enhance the conductivity of the electrode material and are more beneficial for the adsorption of OH* species. It is verified by the differential charge density that the electric field formed on the surface of the electrode can lead to strong interfacial interactions by electron aggregation, which promotes electron/ion transfer kinetics. Furthermore, NiCo-S nanosheets are prepared on carbon cloth enriched with different concentrations of sulfur vacancies (denoted as NiCo-Sv-x, with x representing the concentration of sulfur vacancies) by sulfide etching NiCo-MOF and annealing under H2/Ar atmosphere. The NiCo-Sv-x electrodes obtained are applied to the cathode of supercapacitors and the anode of the oxygen evolution reaction. Through combining experimental and theoretical analysis, the effect of vacancy defect engineering on the electrochemical performance of the electrode materials is further confirmed. This work constructs transition metal sulfides with different sulfur vacancy concentrations through DFT model prediction and experimental validation, further confirming the effect of vacancy defect engineering on the electrochemical performance of electrode materials. Therefore, this modulation of sulfur vacancy concentration by vacancy defects contributes to the construction of electrode materials with excellent performance for energy applications.
|
|
| 4. |
- Li, Yajie, et al.
(författare)
-
Side Channel Attack-Aware Resource Allocation for URLLC and eMBB Slices in 5G RAN
- 2020
-
Ingår i: IEEE Access. - 2169-3536 .- 2169-3536. ; 8, s. 2090-2099
-
Tidskriftsartikel (refereegranskat)abstract
- Network slicing is a key enabling technology to realize the provisioning of customized services in 5G paradigm. Due to logical isolation instead of physical isolation, network slicing is facing a series of security issues. Side Channel Attack (SCA) is a typical attack for slices that share resources in the same hardware. Considering the risk of SCA among slices, this paper investigates how to effectively allocate heterogeneous resources for the slices under their different security requirements. Then, a SCA-aware Resource Allocation (SCA-RA) algorithm is proposed for Ultra-reliable and Low-latency Communications (URLLC) and Enhanced Mobile Broadband (eMBB) slices in 5G RAN. The objective is to maximize the number of slices accommodated in 5G RAN. With dynamic slice requests, simulation is conducted to evaluate the performance of the proposed algorithm in two different network scenarios. Simulation results indicate that compared with benchmark, SCA-RA algorithm can effectively reduce blocking probability of slice requests. In addition, the usage of IT and transport resources is also optimized.
|
|
| 5. |
- Liang, Jiawei, et al.
(författare)
-
Long-term microbiota and performance monitoring of a highly efficient propylene oxide co-production methyl tert-butyl ether production wastewater treatment plant
- 2023
-
Ingår i: Journal of Water Process Engineering. - 2214-7144. ; 56
-
Tidskriftsartikel (refereegranskat)abstract
- A wastewater treatment plant (WWTP) was constructed specifically to treat 543,900 m3 wastewater annually generated by a novel propylene oxide (PO) co-production methyl tert-butyl ether (MTBE) petroleum chemical factory in this study. The WWTP consisted of expanded anaerobic granular sludge beds (EGSBs) and aerobic activate sludge tanks (AASTs), which have been operated for 1340 days. The chemical oxygen demand (COD) and petroleum oils of the WWTP influent were 5140 ± 844 mg/L and 70.08 ± 16.57 mg/L, respectively. The overall removal efficiencies for COD petroleum oils were 94.43% ± 2.36% and 93.46% ± 5.95%, respectively. EGSBs account for 41.48% ± 10.52% of the total COD removal, while AAST contributed to 52.95% ± 10.18%. AAST played a prominent role in the removal of petroleum oils. The optimum COD volume loading rate (VLR) of EGSBs during the operation was 1.83 ± 0.10 kg COD/m3/d, whereas the average COD VLR of AAST was 0.45 ± 0.09 kg COD/m3/d. The composition of dominant microorganisms found in EGSBs and AASTs significantly enhance the performance and efficiency of the WWTP. This study underscores the potential of employing a similar approach for long-term and efficient treatment of industrial complex pollutants, while also highlighting the presence of microbiota with exceptional capability to remove petrochemical contaminants.
|
|
| 6. |
|
|
| 7. |
- Wang, Zhongqiang, et al.
(författare)
-
Realizing 18.03% efficiency and good junction characteristics in organic solar cells via hydrogen-bonding interaction between glucose and ZnO electron transport layers
- 2022
-
Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 11:4, s. 1810-1816
-
Tidskriftsartikel (refereegranskat)abstract
- Electron transport layers (ETLs) with excellent electron extraction capability are essential for realizing high efficiency in organic solar cells (OSCs). A sol-gel-processed ZnO ETL is widely used in OSCs due to its high mobility and suitable work function. However, the existence of defects usually results in low photovoltaic performance during the operation of OSCs. In this work, glucose (Gl) was used to passivate free OH traps via hydrogen-bonding interaction and formed ZnO/Gl ETLs with ZnO, which exhibited improved electron extraction capability and reduced trap defect density. Thus, a champion efficiency of 18.03% was obtained in a PM6:Y6 light absorber-based cell, which is >11% higher than that of the reference cell (16.15%) with a pristine ZnO ETL. Impressive enhancements by >11% were also observed in different fullerene and non-fullerene light absorber-based cells relative to that of the reference cell. This study demonstrates a new strategy to design ETLs for realizing high efficiency in OSCs.
|
|
| 8. |
- Zhao, Jiawei, et al.
(författare)
-
Geochemistry, geochronology and petrogenesis of Maya Block granitoids and dykes from the Chicxulub Impact Crater, Gulf of México: Implications for the assembly of Pangea
- 2020
-
Ingår i: Gondwana Research. - Amsterdam : Elsevier. - 1342-937X .- 1878-0571. ; 82, s. 128-150
-
Tidskriftsartikel (refereegranskat)abstract
- The Late Paleozoic tectono–magmatic history and basement of the Maya block are poorly understood due to the lack of exposures of coeval magmatic rocks in the region. Recently, IODP–ICDP Expedition 364 recovered drill core samples at borehole M0077A from the peak ring of the Chicxulub impact crater, offshore of the Yucatán peninsula in the Gulf of México, have been studied comprehensively. In the lowermost ~600 m of the drill core, impact–deformed granitoids, and minor felsite and dolerite dykes are intercalated with impact melts and breccias. Zircon U-Pb dating of granitoids yielded ages of around 326 ± 5 Ma, representing the first recovery of Late Paleozoic magmatic rocksfrom the Maya block, which could be genetically related to the convergence of Laurentia and Gondwana. The granitoids show the features of high K2O/Na2O, LaN/YbN and Sr/Y ratios, but very low Yb and Y contents, indicating anadakitic affinity. They are also characterized by slightly positive ԑNd(326Ma) of 0.17–0.68, intermediate initial 87Sr/86Sr(326Ma) of 0.7036–0.7047 and two–stage Nd model age (TDM2) of 1027–1069 Ma, which may indicate a less evolved crustal source. Thus, the adakitic granitoids were probably generated by partial melting of thickened crust, with source components similar to Neoproterozoic metagabbro in the Carolina block (Pan–African Orogeny materials) along Peri–Gondwana. Felsite dykes are shoshonitic with typical continental arc features that are sourced from a metasomatic mantle wedge by slab–fluids. Dolerite dykes display OIB–type features such as positive Nb and Ta anomalies and low ThNpm/NbNpm. In our interpretation, the Chicxulub adakitic granitoids of this study are formed by crustal anatexis due to asthenospheric upwelling resulting from slab breakoff. Through comparing sources and processes of Late Paleozoic magmatism along the Peri–Gondwanan realm, a tearing slab break off model may explain the discontinuous magmatism that appears to have occurred during the convergence of Laurentia and Gondwana.
|
|
| 9. |
- Zhao, Nana, et al.
(författare)
-
Atomistic insights into the effects of carbonyl oxygens in functionalized graphene nanopores on Ca2+/Na+ sieving
- 2020
-
Ingår i: Carbon. - : Elsevier. - 0008-6223 .- 1873-3891. ; 164, s. 305-316
-
Tidskriftsartikel (refereegranskat)abstract
- Residual Ca2+ decreases the efficiency and increases the power consumption of the chlor-alkali industry. However, Ca2+ and Na+ sieving is challenging due to the similar ionic radii of these cations. Inspired by the presence of carbonyl oxygens in key selective filters of biological Ca2+ and Na+ channels, we used molecular dynamics to investigate the effects of carbonyl oxygen atoms in modified graphene nanopores of various sizes (characteristic diameters: 0.57–1.50 nm) on Ca2+/Na+ sieving. The results demonstrated that selectivity is closely associated with the different roles of the carbonyl oxygen atoms. In small nanopores, Ca2+ sheds increased numbers of water molecules due to the predominant steric effect of carbonyl oxygen atoms. Thus, Ca2+ must overcome a higher energy barrier than Na+. This requirement prevents the passage of Ca2+. In large nanopores, carbonyl oxygen atoms do preferentially substitute water molecules outside the first hydration shell of Ca2+ compared with those outside the first hydration shell of Na+, thereby hindering Na+ departure from the nanopore. These findings provide useful guidance for the further development of Ca2+ separation materials as sensors and ion separators.
|
|
