| 1. |
- Xia, Yangyang, et al.
(författare)
-
Prediction of bending strength of glass fiber reinforced methacrylate-based pipeline UV-CIPP rehabilitation materials based on machine learning
- 2023
-
Ingår i: Tunnelling and Underground Space Technology. - : Elsevier. - 0886-7798 .- 1878-4364. ; 140
-
Tidskriftsartikel (refereegranskat)abstract
- Ultraviolet cured-in-place-pipe (UV-CIPP) materials are commonly used in trenchless pipeline rehabilitation. Their bending strength is a crucial indicator to evaluate the curing quality. Studies show that this indicator is affected by multiple factors, including the curing time, UV lamp curing power, curing distance, and material thickness. Laboratory experiments have limitations in analyzing the effect of multiple factors on the bending strength of UV-CIPP materials and quantitatively predicting the optimum curing parameters. Aiming at resolving these shortcomings, resolve machine learning techniques were applied to predict the bending strength. In this regard, the surface curing reaction temperature monitoring data and three-point bending data of 30 groups of UV-CIPP material under the influence of different curing parameters were used as a dataset to predict the bending strength of UV-CIPP material. The results show that the influence degree of each factor on the bending strength of the UV-CIPP material, from high to low, is as follows: UV lamp power (−0.439), the temperature at the illuminated side (−0.392), curing time (−0.323), the temperature at the back side (−0.233), curing distance (0.143) and material thickness (−0.140). The best penalty parameter c (44.435) and width g (0.072) of the kernel function in the support vector machine (SVM) model were obtained using the genetic algorithm (GA) optimization, and the results were compared with the grey wolf optimizer (GWO) and particle swarm optimization (PSO). The performed analyses revealed that the developed GA-SVM model exhibits the best prediction results compared to other machine learning algorithms. The optimum bending strength of the UV-CIPP material used in this test is 294.77 MPa, which corresponds to the curing time, UV lamp power, curing distance, material thickness, light side temperature, and back side temperature of 7.59 min, 157.33 mW/cm2, 189.99 mm, 4.38 mm, 79.49 °C, and 76.59 °C, respectively.
|
|
| 2. |
- Zhai, Yinghong, et al.
(författare)
-
Metabolic and Nutritional Disorders Following the Administration of Immune Checkpoint Inhibitors : A Pharmacovigilance Study
- 2021
-
Ingår i: Frontiers in Endocrinology. - : Frontiers Media S.A.. - 1664-2392. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Although several metabolic and nutritional disorders (MNDs) have been reported in the recipients of immune checkpoint inhibitors (ICIs), these events have not been fully captured and comprehensively characterized in real-world population.Objectives: To provide complete metabolic and nutritional toxicity profiles after ICIs (single and combined) initiation through an integrated big database.Methods: Reporting odds ratios (ROR) and information component (IC) based on statistical shrinkage transformation were utilized to perform disproportionality analysis using the US Food and Drug Administration Adverse Events Reporting System. Both ROR and IC were used to calculate disproportionality when compared with the whole database, but only ROR was used when comparison was made for different ICI strategies. Only when both the lower limits of 95% confidence intervals (CIs) for ROR (ROR025) and IC (IC025) exceeded specified threshold values (1 and 0, respectively) was regarded as a signal.Results: A total of 29,294,335 records were involved and 8,662 records were for MNDs in patients exposed to ICIs. Statistically significant association was detected between ICIs use and total MNDs (IC025/ROR025 = 1.06/2.19). For monotherapy, three ICI monotherapies (anti-PD-1, anti-PDL-1, and anti-CTLA-4) were all disproportionately associated with MNDs. Statistically significant differences in reporting frequencies also emerged when comparing anti-PD-1 with anti-PD-L1/anti-CTLA-4 monotherapy, with RORs of 1.11 (95%CI 1.01-1.21), and 1.35 (95%CI 1.23-1.48), respectively. Notably, combination therapy was associated with a higher reporting frequency of theses toxicities compared to monotherapy with a ROR of 1.56 (95%CI 1.48-1.64). Additionally, disproportionality analysis at High-level Group Term level highlighted eight broad entities of MNDs. Further disproportionality analysis at Preferred Term level indicated a wide range and varied strength of signals. For ICI monotherapy, nivolumab and pembrolizumab showed the broadest spectrum of MNDs. For combination therapy, a variety of signals were detected for nivolumab + ipilimumab therapy even comparable to two PD-1 monotherapies.Conclusion: Metabolic and nutritional complications could be provoked by ICI monotherapy (especially anti-PD-1) and further reinforced by combination therapy. Clinicians and patients should be informed about these potential risks that might be encountered in real-world practice. Aforehand education and regular monitoring of related biochemical parameters (calcium, sodium, potassium, protein) are recommended to ensure better cancer survivorship.
|
|
| 3. |
- Zhang, Xinxin, et al.
(författare)
-
China's coal-fired power plants impose pressure on water resources
- 2017
-
Ingår i: Journal of Cleaner Production. - : ELSEVIER SCI LTD. - 0959-6526 .- 1879-1786. ; 161, s. 1171-1179
-
Tidskriftsartikel (refereegranskat)abstract
- Coal is the dominant fuel for electricity generation around the world. This type of electricity generation uses large amounts of water, increasing pressure on water resources. This calls for an in-depth investigation in the water-energy nexus of coal-fired electricity generation. In China, coal-fired power plants play an important role in the energy supply. Here we assessed water consumption of coal-fired power plants (CPPs) in China using four cooling technologies: closed-cycle cooling, once-through cooling, air cooling, and seawater cooling. The results show that water consumption of CPPs was 3.5 km(3), accounting for 11% of total industrial water consumption in China. Eighty-four percent of this water consumption was from plants with closed-cycle cooling. China's average water intensity of CPPs was 1.15 l/kWh, while the intensity for closed-cycle cooling was 3-10 times higher than that for other cooling technologies. About 75% of water consumption of CPPs was from regions with absolute or chronic water scarcity. The results imply that the development of CPPs needs to explicitly consider their impacts on regional water resources.
|
|
| 4. |
- Zheng, Ju, et al.
(författare)
-
Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1
- 2017
-
Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 0006-291X. ; 493:1, s. 708-717
-
Tidskriftsartikel (refereegranskat)abstract
- The subcellular localization of polyQ-expanded huntingtin exon1 (Httex1) modulates polyQ toxicity in models of Huntington's disease. Using genome-wide screens in a yeast model system, we report that the ribosome quality control (RQC) machinery, recently implicated in neurodegeneration, is a key determinant for the nucleocytoplasmic distribution of Httex1-103Q, Deletion of the RQC genes, LTN1 or RQC1, caused the accumulation of Httex1-103Q in the nucleus through a process that required the CAT-tail tagging activity of Rqc2 and transport via the nuclear pore complex. We provide evidence that nuclear accumulation of Httex1-103Q enhances its cytotoxicity, suggesting that the RQC machinery plays an important role in protecting cells against the adverse effects of polyQ expansion proteins. (C) 2017 The Authors. Published by Elsevier Inc.
|
|
