| 1. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 2. |
- Lundström, Anders, et al.
(författare)
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Introduction
- 2014
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Ingår i: Social entrepreneurship. - : Springer. - 9783319013954 ; , s. 3-22
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Bokkapitel (refereegranskat)
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| 3. |
- Lundström, Anders, et al.
(författare)
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Promoting innovation based on social sciences and technologies : The prospect of a social innovation park
- 2011
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Ingår i: Innovation. The European Journal of Social Science Research. - : Informa UK Limited. - 1351-1610 .- 1469-8412. ; 24:1-2, s. 133-149
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Tidskriftsartikel (refereegranskat)abstract
- Obviously Sir Francis Bacon's phrase "Knowledge is Power" refers not only to natural science and technology, aiming at understanding natural phenomena and obtaining material wealth, but also to social sciences and technologies, concerning social ideals and seeking harmonious and sustainable development in society. Innovation and entrepreneurship based on natural sciences and technologies have facilitated science and technology parks in the past; however, innovation and entrepreneurship based on social sciences and technologies are now laying the foundations for the concept of a "social innovation park". The distinctive characteristics of social innovation parks and how social academic entrepreneurship is fostered by them through strategy and policy-making at local, national and global levels are explored in this study.
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| 6. |
- Ren, Chunyan, et al.
(författare)
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Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7
- 2016
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Ingår i: ACS Medicinal Chemistry Letters. - : American Chemical Society (ACS). - 1948-5875. ; 7:6, s. 601-605
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Tidskriftsartikel (refereegranskat)abstract
- The chromobox 7 (CBX7) protein of the polycomb repressive complex 1 (PRC1) functions to repress transcription of tumor suppressor p16 (INK4a) through long noncoding RNA, ANRIL (antisense noncoding RNA in the INK4 locus) directed chromodomain (ChD) binding to trimethylated lysine 27 of histone H3 (H3K27me3), resulting in chromatin compaction at the INK4a/ARF locus. In this study, we report structure-guided discovery of two distinct classes of small-molecule antagonists for the CBX7ChD. Our Class A compounds, a series including analogues of the previously reported MS452, inhibit CBX7ChD/methyl-lysine binding by occupying the H3K27me3 peptide binding site, whereas our Class B compound, the newly discovered MS351, appears to inhibit H3K27me3 binding when CBX7ChD is bound to RNA. Our crystal structure of the CBX7ChD/MS351 complex reveals the molecular details of ligand recognition by the aromatic cage residues that typically engage in methyl-lysine binding. We further demonstrate that MS351 effectively induces transcriptional derepression of CBX7 target genes, including p16 (INK4a) in mouse embryonic stem cells and human prostate cancer PC3 cells. Thus, MS351 represents a new class of ChD antagonists that selectively targets the biologically active form of CBX7 of the PRC1 in long noncoding RNA- and H3K27me3-directed gene transcriptional repression.
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| 7. |
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Social Entrepreneurship : Leveraging Economic, Political, and Cultural Dimensions
- 2014
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- This contributed volume features state-of-the-art research from ten different countries on implementation, institutionalization and the future prospects of social entrepreneurship. This volume aims at bringing together research that considers the context of economy, politics and cultural issues combining with the needs of social and human development. By conceptualizing the notion of social entrepreneurship and societal entrepreneurship, this volume aims to disseminate the numerous streams of research and theory of social entrepreneurship to educators, libraries, scholars, non-profit researchers, public policy makers, practitioners, undergraduate and graduate students, and any organization or person interested in staying abreast of advances in this area. It is also an important reference book for teachers, students and faculty interested in conducting research or teaching social entrepreneurship.
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| 8. |
- Song, Jie, 1984-, et al.
(författare)
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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
- 2022
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 82
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundTransforming growth factor β (TGFβ) is overexpressed in several advanced cancer types and promotes tumor progression. We have reported that the intracellular domain (ICD) of TGFβ receptor (TβR) I is cleaved by proteolytic enzymes in cancer cells, and then translocated to the nucleus in a manner dependent on the endosomal adaptor proteins APPL1/2, driving an invasiveness program. How cancer cells evade TGFβ-induced growth inhibition is unclear.MethodsWe performed microarray analysis to search for genes regulated by APPL1/2 proteins in castration-resistant prostate cancer (CRPC) cells. We investigated the role of TβRI and TRAF6 in mitosis in cancer cell lines cultured in 10% FBS in the absence of exogenous TGFβ. The molecular mechanism of the ubiquitination of AURKB by TRAF6 in mitosis and the formation of AURKB–TβRI complex in cancer cell lines and tissue microarrays was also studied.FindingsDuring mitosis and cytokinesis, AURKB–TβRI complexes formed in midbodies in CRPC and KELLY neuroblastoma cells. TRAF6 induced polyubiquitination of AURKB on K85 and K87, protruding on the surface of AURKB to facilitate its activation. AURKB–TβRI complexes in patient's tumor tissue sections correlated with the malignancy of prostate cancer.InterpretationThe AURKB–TβRI complex may become a prognostic biomarker for patients with risk of developing aggressive PC.
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| 9. |
- Zhang, Qinghua, et al.
(författare)
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Quantitative assessments of retinal macular structure among rural-dwelling older adults in China : a population-based, cross-sectional, optical coherence tomography study
- 2024
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Ingår i: BMJ Open. - 2044-6055. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesTo quantitatively assess and compare retinal macular structures of rural-dwelling older adults in China using two different optical coherence tomography (OCT) scanners and to examine their associations with demographic, lifestyle, clinical and ocular factors.Design, setting and participants This population-based, cross-sectional study included 971 participants (age ≥60 years) derived from the Multimodal Interventions to Delay Dementia and Disability in Rural China study. We collected data on demographics, lifestyle factors, clinical conditions (eg, cardiovascular disease (CVD)) and ocular factors (eg, visual acuity and spherical equivalent). We used two models of spectral-domain OCT to measure macular parameters in nine Early Treatment Diabetic Retinopathy Study subfields. Data were analysed using the multiple general linear models.Results Spectralis OCT demonstrated higher macular thickness but a lower macular volume than Primus 200 OCT (p<0.05). Nasal quadrant of the inner and outer subfields was the thickest, followed by superior quadrant. Adjusting for multiple potential confounding variables, older age was significantly correlated with lower average inner and outer macular thicknesses and overall macular volume. Men had higher macular parameters than women. The presence of CVD was correlated with lower central macular thickness (β=−6.83; 95% CI: −13.08 to −0.58; p=0.032). Middle school or above was associated with higher average inner macular thickness (β=7.85; 95% CI: 1.14 to 14.55; p=0.022) and higher spherical equivalent was correlated with lower average inner macular thickness (β=−1.78; 95% CI: −3.50 to −0.07; p=0.042).Conclusions Macular thickness and volume assessed by Spectralis and Primus 200 OCT scanners differ. Older age and female sex are associated with lower macular thickness and volume. Macular parameters are associated with education, CVD and spherical equivalent.Trial registeration number MIND-China study (ChiCTR1800017758).
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