| 1. |
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| 2. |
- Wen, Gen, et al.
(författare)
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An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension
- 2007
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 16:14, s. 1752-1764
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Tidskriftsartikel (refereegranskat)abstract
- Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence for association between a regulatory polymorphism in Secretogranin II (SCG2) and hypertension in African-American subjects. The minor allele is ancestral in the human lineage and is associated with disease risk in two case-control studies and with elevated blood pressure in a separate familial study. Mechanistically, the ancestral allele acts as a transcriptional enhancer in cells that express endogenous Scg2, whereas the derived allele does not. ARIX (PHOX2A) and PHOX2B are identified as potential transactivating factors by oligonucleotide affinity chromatography and mass spectrometry and confirmed by chromatin immunoprecipitation. Each of these transcription factors preferentially binds the risk allele, both in vitro and in vivo. Population genetic considerations suggest positive selection of the protective allele within the human lineage. These results identify a common regulatory variation in SCG2 and implicate granin gene expression in the control of human blood pressure and susceptibility to hypertension.
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| 3. |
- Zhou, Ke, et al.
(författare)
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pi-pi Stacking Distance and Phase Separation Controlled Efficiency in Stable All-Polymer Solar Cells
- 2019
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Ingår i: Polymers. - : MDPI. - 2073-4360. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- The morphology of the active layer plays a crucial role in determining device performance and stability for organic solar cells. All-polymer solar cells (All-PSCs), showing robust and stable morphologies, have been proven to give better thermal stability than their fullerene counterparts. However, outstanding thermal stability is not always the case for polymer blends, and the limiting factors responsible for the poor thermal stability in some All-PSCs, and how to obtain higher efficiency without losing stability, still remain unclear. By studying the morphology of poly [2,3-bis (3-octyloxyphenyl) quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl](TQ1)/poly[4,8-bis[5-(2-ethylhexyl)-2-thienyl]benzo[1,2-b:4,5-b ]dithiophene-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]thiophene-)-2-carboxylate-2-6-diyl]] (PCE10)/PNDI-T10 blend systems, we found that the rearranged molecular packing structure and phase separation were mainly responsible for the poor thermal stability in devices containing PCE10. The TQ1/PNDI-T10 devices exhibited an improved PCE with a decreased pi-pi stacking distance after thermal annealing; PCE10/PNDI-T10 devices showed a better pristine PCE, however, thermal annealing induced the increased pi-pi stacking distance and thus inferior hole conductivity, leading to a decreased PCE. Thus, a maximum PCE could be achieved in a TQ1/PCE10/PNDI-T10 (1/1/1) ternary system after thermal annealing resulting from their favorable molecular interaction and the trade-off of molecular packing structure variations between TQ1 and PCE10. This indicates that a route to efficient and thermal stable All-PSCs can be achieved in a ternary blend by using material with excellent pristine efficiency, combined with another material showing improved efficiency under thermal annealing.
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| 4. |
- Chang, Tzu-Hsuan, et al.
(författare)
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Selective release of InP heterostructures from InP substrates
- 2016
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Ingår i: Journal of Vacuum Science & Technology B. - : American Institute of Physics (AIP). - 1071-1023 .- 1520-8567. ; 34:4
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Tidskriftsartikel (refereegranskat)abstract
- The authors report here a method of protecting the sidewall for the selective release of InGaAsP quantum-well (QW) heterostructure from InP substrates. An intact sidewall secured by SiO2 was demonstrated during the sacrificial layer selective etching, resulting in the suspended InGaAsP QW membranes which were later transferred to the Si substrate with polydimethylsiloxane stamp. The quality of the transferred InGaAsP QW membranes has been validated through photoluminescence and EL measurements. This approach could extend to arbitrary targeting substrate in numerous photonics and electronics applications.
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| 5. |
- Gu, Tian, et al.
(författare)
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Hybrid Integrated Photonic Platforms : feature issue introduction
- 2021
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Ingår i: Optical Materials Express. - : The Optical Society. - 2159-3930 .- 2159-3930. ; 11:12, s. 4095-4096
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Hybrid photonic integration and interfaces allow different optical materials and components to be combined on a single platform and thus are crucial to future integrated photonic systems. This feature issue covers frontier research, technologies, and perspectives in this rapidly-evolving area and aims to address the key challenges and requirements across a broad range of photonic technologies.
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| 6. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 7. |
- Li, Xiangdong, et al.
(författare)
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Towards personalized virtual reality touring through cross-object user interfaces
- 2019
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Ingår i: Personalized Human-Computer Interaction. - : Walter de Gruyter. - 9783110552485 ; , s. 201-222
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Real-time adaptation is one of the most important problems that currently require a solution in the field of personalized human-computer interaction. For conventional desktop system interactions, user behaviors are acquired to develop models that support context-aware interactions. In virtual reality interactions, however, users operate tools in the physical world but view virtual objects in the virtual world. This dichotomy constrains the use of conventional behavioral models and presents difficulties to personalizing interactions in virtual environments. To address this problem, we propose the cross-object user interfaces (COUIs) for personalized virtual reality touring. COUIs consist of two components: a Deep Learning algorithm-based model using convolutional neural networks (CNNs) to predict the user’s visual attention from the past eye movement patterns to determine which virtual objects are likely to be viewed next, and delivery mechanisms that determine what should when and where be displayed on the user interface. In this chapter, we elaborate on the training and testing of the prediction model and evaluate the delivery mechanisms of COUIs through a cognitive walk-through approach. Furthermore, the implications for using COUIs to personalize interactions in virtual reality (and other environments such as augmented reality and mixed reality) are discussed.
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| 8. |
- Liao, Guangdong, et al.
(författare)
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Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China
- 2020
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.
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| 9. |
- Liotta, Lance A., et al.
(författare)
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Clinical proteomics and molecular pathology
- 2020
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Ingår i: Essential Concepts in Molecular Pathology. - : Elsevier BV. ; , s. 149-163
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease.
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| 10. |
- Liu, Shih-Chia, et al.
(författare)
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Photonic crystal bandedge membrane lasers on silicon
- 2017
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Ingår i: Applied Optics. - 1559-128X .- 2155-3165. ; 56:31, s. H67-H73
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Tidskriftsartikel (refereegranskat)abstract
- We report here the design and experimental demonstration of optically pumped photonic crystal bandedge membrane lasers on silicon-on-insulator (SOI) and on bulk silicon (Si) substrates, based on heterogeneously integrated InGaAsP multi-quantum-well membrane layers transfer printed onto patterned photonic crystal cavities. Singlemode lasing under room-temperature operation was observed at 1542 nm, with excellent side mode suppression ratio greater than 31.5 dB, for the laser built on SOI substrate. For the laser built on bulk Si substrate, single-mode lasing was also achieved at 1452 nm with much lower thermal resistance, as compared to that of the laser built on SOI substrates. Such improved thermal characteristics are favorable for lasers operating potentially at higher temperatures and higher power.
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