| 1. |
- Zhang, Huai, et al.
(författare)
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease.
- 2024
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Ingår i: Hepatology international. - 1936-0541.
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Tidskriftsartikel (refereegranskat)abstract
- With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p=0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.
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| 2. |
- Huo, Kaiming, et al.
(författare)
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Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment.
- 2011
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Ingår i: Endocrine Journal. - 1348-4540 .- 0918-8959. ; 58:5, s. 355-61
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Tidskriftsartikel (refereegranskat)abstract
- Neurodevelopment in children with congenital hypothyroidism who receive early treatment is generally good. However, subtle neurological deficits still exist in some patients. The aim of this investigation was to evaluate factors that may influence neurodevelopmental outcome in congenital hypothyroidism patients. The developmental quotient (DQ) of 155 children with congenital hypothyroidism was evaluated at 24 months of age, using Gesell Developmental Schedules (GDS), and compared with that of 310 healthy controls. Mean DQ scores in congenital hypothyroidism patients were 7.5 points lower for adaptive behavior than in control patients (p
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| 3. |
- Kim, Jae-Young, et al.
(författare)
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Event Horizon Telescope imaging of the archetypal blazar 3C 279 at an extreme 20 microarcsecond resolution
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 640
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Tidskriftsartikel (refereegranskat)abstract
- 3C 279 is an archetypal blazar with a prominent radio jet that show broadband flux density variability across the entire electromagnetic spectrum. We use an ultra-high angular resolution technique - global Very Long Baseline Interferometry (VLBI) at 1.3mm (230 GHz) - to resolve the innermost jet of 3C 279 in order to study its fine-scale morphology close to the jet base where highly variable-ray emission is thought to originate, according to various models. The source was observed during four days in April 2017 with the Event Horizon Telescope at 230 GHz, including the phased Atacama Large Millimeter/submillimeter Array, at an angular resolution of ∼20 μas (at a redshift of z = 0:536 this corresponds to ∼0:13 pc ∼ 1700 Schwarzschild radii with a black hole mass MBH = 8 × 108 M⊙). Imaging and model-fitting techniques were applied to the data to parameterize the fine-scale source structure and its variation.We find a multicomponent inner jet morphology with the northernmost component elongated perpendicular to the direction of the jet, as imaged at longer wavelengths. The elongated nuclear structure is consistent on all four observing days and across diffierent imaging methods and model-fitting techniques, and therefore appears robust. Owing to its compactness and brightness, we associate the northern nuclear structure as the VLBI "core". This morphology can be interpreted as either a broad resolved jet base or a spatially bent jet.We also find significant day-to-day variations in the closure phases, which appear most pronounced on the triangles with the longest baselines. Our analysis shows that this variation is related to a systematic change of the source structure. Two inner jet components move non-radially at apparent speeds of ∼15 c and ∼20 c (∼1:3 and ∼1:7 μas day-1, respectively), which more strongly supports the scenario of traveling shocks or instabilities in a bent, possibly rotating jet. The observed apparent speeds are also coincident with the 3C 279 large-scale jet kinematics observed at longer (cm) wavelengths, suggesting no significant jet acceleration between the 1.3mm core and the outer jet. The intrinsic brightness temperature of the jet components are ≤1010 K, a magnitude or more lower than typical values seen at ≥7mm wavelengths. The low brightness temperature and morphological complexity suggest that the core region of 3C 279 becomes optically thin at short (mm) wavelengths.
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| 4. |
- Tang, Ting-Ting, et al.
(författare)
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Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.
- 2011
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 6:9, s. e24272-
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Tidskriftsartikel (refereegranskat)abstract
- Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.
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| 5. |
- Zhu, Jun, 1976-
(författare)
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Energy and Design Cost Efficiency for Streaming Applications on Systems-on-Chip
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- With the increasing capacity of today's integrated circuits, a number ofheterogeneous system-on-chip (SoC) architectures in embedded systemshave been proposed. In order to achieve energy and design cost efficientstreaming applications on these systems, new design space explorationframeworks and performance analysis approaches are required. Thisthesis considers three state-of-the-art SoCs architectures, i.e., themulti-processor SoCs (MPSoCs) with network-on-chip (NoC) communication,the hybrid CPU/FPGA architectures, and the run-time reconfigurable (RTR)FPGAs. The main topic of the author?s research is to model and capturethe application scheduling, architecture customization, and bufferdimensioning problems, according to the real-time requirement. Sincethese problems are NP-complete, heuristic algorithms and constraintprogramming solver are used to compute a solution.For NoC communication based MPSoCs, an approach to optimize thereal-time streaming applications with customized processorvoltage-frequency levels and memory sizes is presented. A multi-clockedsynchronous model of computation (MoC) framework is proposed inheterogeneous timing analysis and energy estimation. Using heuristicsearching (i.e., greedy and taboo search), the experiments show anenergy reduction (up to 21%) without any loss in application throughputcompared with an ad-hoc approach.On hybrid CPU/FPGA architectures, the buffer minimization scheduling ofreal-time streaming applications is addressed. Based on event models,the problem has been formalized decoratively as constraint basescheduling, and solved by public domain constraint solver Gecode.Compared with traditional PAPS method, the proposed method needssignificantly smaller buffers (2.4% of PAPS in the best case), whilehigh throughput guarantees can still be achieved.Furthermore, a novel compile-time analysis approach based on iterativetiming phases is proposed for run-time reconfigurations in adaptivereal-time streaming applications on RTR FPGAs. Finally, thereconfigurations analysis and design trade-offs analysis capabilities ofthe proposed framework have been exemplified with experiments on bothexample and industrial applications.
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| 6. |
- Zhu, Jun, 1976-
(författare)
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Performance Analysis and Implementationof Predictable Streaming Applications onMultiprocessor Systems-on-Chip
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Driven by the increasing capacity of integrated circuits, multiprocessorsystems-on-chip (MPSoCs) are widely used in modern consumer electron-ics devices. In this thesis, the performance analysis and implementationmethodologies are explored to design predictable streaming applications onMPSoCs computing platforms. The application functionality and concur-rency are described in synchronous data flow (SDF) computational models,and two state-of-the-art architecture templates are adopted as multiproces-sor architectures, i.e., network-on-chip (NoC) based MPSoC and hybrid re-configurable CPU/FPGA platforms. Based on the author’s contributions onsimulation and formal analytical methods, performance analysis and designspace exploration for embedded MPSoCs architectures have been addressed. An energy efficient design space exploration flow is proposed for stream-ing applications with guaranteed throughput on NoC based MPSoCs, in whichboth application throughput analysis and system energy calculation are car-ried out by simulation on a multi-clocked synchronous modelling frame-work. On the other hand, based on event models of data streams, a formalanalytical scheduling framework for real-time streaming applications withminimal buffer requirement on hybrid CPU/FPGA architectures is exploited.The scheduling problem has been formalized declaratively by constraint basetechniques, and solved by a public domain constraint solver. Consecutively,the constraint based method has been extended to solve problems rangingfrom global computation/communication scheduling and reconfiguration anal-ysis to Pareto efficient design. Finally, a prototype of stream processing sys-tem on FPGA based MPSoC is built to substantiate the results from theoreti-cal studies in this thesis.
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